UNC80_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: UNC80_DROME
• UniProt AC: Q9VB11
• Protein Name: Protein unc-80 homolog
• Gene Name: unc80 {ECO:0000312|FlyBase:FBgn0039536}
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 3303
• Subcellular Localization: Membrane ; Multi-pass membrane protein .
• Protein Description: Component of the na (narrow abdomen) sodium channel complex. In the circadian clock neurons it functions with na and unc79 to promote circadian rhythmicity..
• Protein Sequence: MVTNAAGTAATGGATSNTTNNNNLQTNNNSHGANNNNDDFDFDQDSGLQDLGLPVSVQTFLWRQIAPFIRPKLGKLHESTCLFCQHAPGHHESKEACKSFEKVLVQNIQFGLSPPLTKGLGVIPRWRLLQGALPHVMHACAALLYNRVKDMQAIGPVETKLLYTMQWILLYAAEECADDEGGEDLGLGDAAEPKSKSIDQYLFSVPTITLFVYLFAPIIHHLKESDFQNFRLENGIKLWQGMWDNRAPGAPCFTAPVKPKARNLLCAPTPKGSTDVFPARKHSLSADAMSPKADSPQSGISDYGRQDEEGSWVSSPKEFAFPETIPEEASSVEDERVVIFRLPSAPQLMDNSFFTADASLLQQQQSQSRRGSRQSMNSRDKDKVPSTKFEFDQQELMRGASMKEKRSASIEKETDSDKSESIKADVSAATFLDVAVLRCLFISHWQEEGIFWSLQYLYNRLSDIGEEAAITLNQPRKRSNSLPIPQIEISLYQGPGSNSRDSPGSSVVKDYIEIPDPSPTVTACVAEEPQSAPSTTERRGSEKKKRVKMADLRAFVETKMFSKSEKNLEKVGLDTNSANGKTPLQHAEYHRSLDTGEKKLSRSASMISREPASNLIKGKSMPSLRFYRYVEPPKAPRPSQATCPRSTAFYPRNPIITVTEHTPTPSPDYMKRQGSIDSQLDALSNGGSIAGMTGNGGGNGSTGMGSSTTRYRGQMLRSHTDSHIDYTGVDESEAPGSSFYITRDGGIDYEIILLAISNVFKRDPAQVCSLRVLEAGLNICELLIEMGVLKLGEHAHEISMSITRRALQVLGCPHGCNDGVRGPPADFLRNQCQKILSRMLRQAGQRTKRFMQEMVKTSPLPELIDYFHAFLAFCVDPSSLLSPLSQGGYSTNFSGGMSGGAEAQVVGAVFKPLVSRFVEASKDLKGPENIALYGDIRQLVTYVKGAHGGPFRLVALSGILAVTPRPHKKGPSAQTTRVIRHIPQANANQSLQNDDNRSQRRLLLKKRSTSSACASLLETEACEEHYKTSQSPLSNFRRRTTGVRPTLTPRHSERALLSDSTSSSERNSLGRLSGLVRWFRGTPKEASSIDLEIGSLNPEISSTFMRHASLKIQRGRSSDGIGRSIQRAKRRVERRLNRFGGIVKGKKKVGGIEETADFSRRSSSDMCDGPRESEVVILKERKLVPTEPVRVGMLRLSFLLETCAPGSFPDPQLVAAVLDLPQAPLVARATFLLECAHFVHLCNKGQWPAWMKQNVGSYRASGANINLNQMKQQVSQTSARRTHILQRAAGKMFHQWAEMVGARLEEILFTERLQYEAVNASLTDPEKQRELLQQDEEEDFLDETSVNPHGNDCPHSLKLIACVLLFEITAFLRDTYLMLPKTSKLIHRDKPAPWEKVYREANRRWSMALSSMGHSQTSAQSLQSIAAGNDGAGQSERKISFVLHEPDNESENSSNTTLTKEGEEARRPTTSAVRPFLLRRGTATTTGGSFKRRSLKLRRNTKDSKDIETDFNMQSRRKVSSLSDRSDTSEQGMISGGEESPGILSDDQQPESPTDSNENDDTAKNMPWLKAIIDLMSSYNYYCTHKGYCHPFCYKRHMRSCTRLVKATRKVYGEEFGFTFDADHPNVEPTIITSSKPHTSRARSTRKVSEQSSTQTSPSKRKDSLSRKDRISDDPDLEMAEKLAKAFRQEKEKKMQEEPPILKFIRIHIRNLFHFPLATLLKGAVVLTEEMVIEAMPAAWELLLETNHDTATSSAAVFLMGSVKAQNFAFDIMQRALKHKDPDIRIGAIQRYLVLWKCRFHVWPRMEENAHDVTFKVPPGGIEFTLPSPKIGIESLPVVDPPWMPVQQTKDMDVTLNQDRHRSLVTATKSRKMQQTEAIRNALRQQRDKQRAERHSFLITMIPISQQASHEPGMEKLEDHEIEEDLDGTRMSSHLHHAHSLFPSVLCSSVMQIVGCLDDAAIGSDGNAVYEIAYQVIWVCLVEESALFLRYVFERLTRDRQDQMFKLLRHLIRFVPRLPQQAAFALYNSIIGYIMFYVRSSNELKQELVGSALSVLWMVVHSVHGIMFKDLKQILRKEQCDASILLTANVPAAKKIVVHGPADDDYNIPSQFPVQEDTLFCQLLKEALDYYPIDEKNTSHYCLVDYKSSKILNPNWYIRDLYFFKRSQYPEVRLMLMRPEESFLALQKQELTKKFVEIGKVHLTWAILKNVDMVVQRVVFLHEELMKLPSFPRKALEVDLDLHHGGEYGKVLLGLDVLHKFMWVRLIARMFEAMAGNFAYSADIQLFLNVLSGASILHAEDSCIMRYVMATFINAAFNFKNIFSTNGYFMIMPTLLQVYSLHQTNKLITTTIEYAVKQFYLLNRKPFILQMFGSVSAILDTDEDGTYGEAHKVQSSCLFNLLLSLEDPSPDPLNIAELVKEPKPLKAIDFCYHDEDDDVTVLDCITLCVMVVSYSAESTRGYQMLIILEAILPCYLQQIQSPSYIPLQGKSERDIILQLAVAIRTMVHNCEGLAKSYNGPYRNSPEHKGSSQRNCSRGPPCSPGLDFEEETHPKYMTDARTKNMMDSAEDSEMIRTEYRRPRDVLLSVVADFLTKSTVRLAELAKKMPSDTKPTEVLDAKCHIRLADIAHSLLKVSPYDPESMACRGLQRYMQAVLPRAEWSNDTLRNALVTILRRIDKVFLKISKKPSIRRNTDWEAAAGLLKGIHETIIRHSYVLHWQQMKTLISTVQNLIVNEPGIPEGVSSAGAALMSQNPPAFFCSAVVRLVALQVVSPVDCFSLVQICGGSSEFATQEKAEGFLMHLIMPLCLKVCSGRGVSDVGELKMSDVSFLLTAVLNAMSPPAGRTGQAVSQINRVTGDLRAGSLTFTGSRDAKRPARISGSLYQAAFLALRIVCICFESRLSNEWPRIVRVMRDLGRRNEAAPDLWSFMEFVVTHRTPLYIVLLPFILHKISQPPIGDHERHMQFIIRERLRGTPPQGGIKSKGALLLELARELRDLRDELEEKRYDRESSEQKKSDTPAATSAAEAHKSQQRPSLISIFTGTTTGQASHSHVSAVPIDSRSGSGGICTPSDTLSQQTLHPPRESLSSSSTGRDPHTTTSESQSGEADAGSAPTLVGATPSGSGHGSGGGIGTGAASAVPSHLSHSQSLQQAPFKAQPPKLRFVSSVEFRHSSGETSTTPLSPESPAEDSSGDHTRSRLQRSKAASRKTFRLKRSRLTPMEPPSIVTSQEEQAPQAQAKTLGEISWDSVSQTSSTSGYRDNNSLQTGLLSPDGSLGGLTLGRSPSQHSLLMVFEGQDEDTLI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
295	Phosphorylation	AMSPKADSPQSGISD CCCCCCCCCCCCCCC	26.26	27794539
1450	Phosphorylation	LHEPDNESENSSNTT EECCCCCCCCCCCCC	67.61	27794539
1657	Phosphorylation	EQSSTQTSPSKRKDS CCCCCCCCCCHHHCC	48.24	27794539
1672	Phosphorylation	LSRKDRISDDPDLEM CCCHHCCCCCCCHHH	4.44	27794539
2524	Phosphorylation	YNGPYRNSPEHKGSS CCCCCCCCCCCCCCC	2.98	27794539

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of UNC80_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of UNC80_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of UNC80_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.