SIN1_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SIN1_DROME
• UniProt AC: Q9V719
• Protein Name: Stress-activated map kinase-interacting protein 1
• Gene Name: Sin1
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 569
• Protein Description: Component of a multiprotein complex that phosphorylates Akt1, a protein that regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes..
• Protein Sequence: MATYSNQHWLLSHIRNSFISTDDTGMCETVMLSDDMPKHYLRKFGNSGAGGDHYHWRRAHKTPPTGGGTTPERNTRHPDAPLQEVDFICYPGLDLSDDEEDMSTHSFDIQMYPEVGAHRFRSNTAQKLEKLDIAKRRAARIKSVNYQEEVQPPESDDFFKRKELPLSKAERVKNEPKANDDDLSDEGVQSQLTEQLAKSPKQAQNRFIEFARFDGTSQVGMQTKRINVFLNMLPEPDRNYPLKICVVATAKIQEVIGFVCYRTSLQYPDVPLKSLQHYALYMTEDNDDMEDFPPLDNREPCSKFGFSQLTLAERRPLAPVTRVDYHSQLGSKSMTSVEDKTALSDAAVKALQNISLNGGTSDPGGGGGGGDSPHDNVKEYEKRLLNHNDMLEAPMHRTFRLNIIDKRFFKSDVTLGISGERIEIDQCKNAKFWPQKKPVSTPIDFVAHCEILERRHLKALLRIWLKSNSSSPSFSTGCTSAPINASVTTLNAGSGSGGIAHSPSSPGHSSGLFSSSNIRFKHYDFDTDTHTAEQIHNKLNCILEMRSSDLRREFLLQRDRKQEKRQLKL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
96	Phosphorylation	CYPGLDLSDDEEDMS EECCCCCCCCCCHHH	42.56	22817900
184	Phosphorylation	KANDDDLSDEGVQSQ CCCCCCCCHHHHHHH	40.38	19429919
307	Phosphorylation	PCSKFGFSQLTLAER CHHHCCCCCCCCCCC	25.35	21082442
333	Phosphorylation	HSQLGSKSMTSVEDK CHHCCCCCCCCCCCH	29.05	22817900
355	Phosphorylation	VKALQNISLNGGTSD HHHHHCCCCCCCCCC	24.27	22817900
372	Phosphorylation	GGGGGGDSPHDNVKE CCCCCCCCCCCCHHH	27.66	19429919
502	Phosphorylation	GSGGIAHSPSSPGHS CCCCCCCCCCCCCCC	19.91	22817900
504	Phosphorylation	GGIAHSPSSPGHSSG CCCCCCCCCCCCCCC	52.78	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SIN1_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SIN1_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SIN1_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TRC_DROME	trc	physical	19875983
TRC_DROME	trc	genetic	19875983
LST8_DROME	Lst8	physical	22068330
1433E_DROME	14-3-3epsilon	physical	22068330
UNK_DROME	unk	physical	22068330
PELI_DROME	Pli	physical	22068330
TOR_DROME	Tor	physical	22068330
TOR_DROME	Tor	physical	23348839

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-333; SER-355; SER-372AND SER-504, AND MASS SPECTROMETRY.
PubMed: 18327897