UNK_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: UNK_DROME
• UniProt AC: Q86B79
• Protein Name: RING finger protein unkempt
• Gene Name: unk
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 599
• Subcellular Localization: Cytoplasm .
• Protein Description: Essential for late larval/early pupal development..
• Protein Sequence: MLANETNKLLLSSQQEKPNHYTYLKEFRVEQCQSFLQHKCNQHRPFVCFNWHFQNQRRRRPVRKRDGTFNYSADNYCTKYDETTGICPEGDECPYLHRTAGDTERRYHLRYYKTCMCVHDTDSRGYCVKNGLHCAFAHGMQDQRPPVYDIKELETLQNAESTLDSTNALNALDKERNLMNEDPKWQDTNYVLANYKTEPCKRPPRLCRQGYACPQYHNSKDKRRSPRKYKYRSTPCPNVKHGEEWGEPGNCEAGDNCQYCHTRTEQQFHPEIYKSTKCNDVQQAGYCPRSVFCAFAHVEPCSMDDPRENSLSASLANTSLLTRSSAPINIPNTTLSNSINDFNSGSFAVNIPSSSLTYSPTNHANLFNVDAFNYGGSNKLSNSLSATQNDSSLFFPSRIISPGFGDGLSISPSVRISELNTIRDDINSSSVGNSLFENTLNTAKNAFSLQSLQSQNNSDLGRITNELLTKNAQIHKLNGRFEDMACKLKIAELHRDKAKQEAQEWKERYDLAQIQLNLPAELRDLSIQKLKQLQSKLRTDLEEVDKVLYLENAKKCMKCEENNRTVTLEPCNHLSICNTCAESVTECPYCQVPVITTHT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
319	Phosphorylation	SASLANTSLLTRSSA CHHHHCCHHHCCCCC	22.61	21082442
322	Phosphorylation	LANTSLLTRSSAPIN HHCCHHHCCCCCCCC	33.52	21082442
358	Phosphorylation	IPSSSLTYSPTNHAN CCCCCCCCCCCCCCC	20.25	21082442
381	Phosphorylation	YGGSNKLSNSLSATQ CCCCCCCCCCCCCCC	26.44	29892262
383	Phosphorylation	GSNKLSNSLSATQND CCCCCCCCCCCCCCC	21.96	29892262
387	Phosphorylation	LSNSLSATQNDSSLF CCCCCCCCCCCCCCC	25.24	29892262
401	Phosphorylation	FFPSRIISPGFGDGL CCCCEEECCCCCCCC	19.32	19429919
409	Phosphorylation	PGFGDGLSISPSVRI CCCCCCCCCCCCEEH	26.92	19429919
411	Phosphorylation	FGDGLSISPSVRISE CCCCCCCCCCEEHHH	14.03	19429919
413	Phosphorylation	DGLSISPSVRISELN CCCCCCCCEEHHHCC	19.76	19429919
429	Phosphorylation	IRDDINSSSVGNSLF CCCCCCCCCHHCHHH	25.26	29892262
430	Phosphorylation	RDDINSSSVGNSLFE CCCCCCCCHHCHHHH	33.59	22817900
434	Phosphorylation	NSSSVGNSLFENTLN CCCCHHCHHHHHHHH	28.62	22817900
448	Phosphorylation	NTAKNAFSLQSLQSQ HHHHHHHHHHHHHHC	24.08	19429919
451	Phosphorylation	KNAFSLQSLQSQNNS HHHHHHHHHHHCCCC	33.40	21082442
454	Phosphorylation	FSLQSLQSQNNSDLG HHHHHHHHCCCCHHH	39.92	19429919
458	Phosphorylation	SLQSQNNSDLGRITN HHHHCCCCHHHHHHH	41.59	19429919

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of UNK_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of UNK_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of UNK_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HDC_DROME	hdc	physical	22036573
RHEB_DROME	Rheb	genetic	25210733
LST8_DROME	Lst8	physical	22068330
SIN1_DROME	Sin1	physical	22068330
HDC_DROME	hdc	physical	22068330
HDC_DROME	hdc	physical	25210733
TOR_DROME	Tor	physical	22068330

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"An integrated chemical, mass spectrometric and computational strategyfor (quantitative) phosphoproteomics: application to Drosophilamelanogaster Kc167 cells.";
Bodenmiller B., Mueller L.N., Pedrioli P.G.A., Pflieger D.,Juenger M.A., Eng J.K., Aebersold R., Tao W.A.;
Mol. Biosyst. 3:275-286(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-411, AND MASSSPECTROMETRY.
PubMed: 17372656