HDC_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HDC_DROME
• UniProt AC: Q9N2M8
• Protein Name: Headcase protein
• Gene Name: hdc
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 1080
• Subcellular Localization: Cytoplasm.
• Protein Description: Required for imaginal cell differentiation, may be involved in hormonal responsiveness during metamorphosis. Involved in an inhibitory signaling mechanism to determine the number of cells that will form unicellular sprouts in the trachea. Regulated by transcription factor esg. The longer hdc protein is completely functional and the shorter protein carries some function..
• Protein Sequence: MAPRRNSNISSSGNSTQQQHQQQLQQQHQTQQHQLLQFYAENVNSSGVLMAPMQGTGGVGGVGGGGMVHCCLPSGDCRKLDTLIHLNELSLADCIRVLCNNENCSAGQYMHRECFEWWEASVLQALKANGRARSWSERQRLQHLWTKKGYELVQKACSCKCGRGQLRKDLDWVPPSSQGVIYLNGSGNRPTLANGSLSEDDDKKKAKKKRNRNNNNNNGGGGGGGAGVNGNTKTPLSNNNGNSYAGLTPNPNVGVIGSGLPHNNGNTASNGSSGNNGSSGVLQTSALATFSNILNTNNVLGLDLRARAGSLSSSGAGSGSTSPSDSQSSGEISVSPVQQLLPQQQQQQQQSLLIQPLGPAFGSNLLQNGLGLSKNLLIAPQQQQQQQLQQQQQQQNNLPALANISNFKPLASYEQQQLVQQQKNKEVELYSDRVRSTSGCNGIFSRRLDFSSFNLLPKTRLNSYQVKIEDEGNHGNDETRLFILSSLAQSQMSRVACILCEEPLLVFDRYPLVDGSFFLSPKQHSSGCIEVKYEGRTLYLTCVCMSCLDGTSSSRAINCRFCKEPWDGSSLVLGTMYAYDIFAAMPCCAERFKCNNCFKMLMHPQQRLSFYSDYSHGVTCPYCNTQDTHFVKPLTFCYAKTTATRLPTLAXHEAPLESPVGTGATTTQVPNAQGSPTASGCSSNTIASKQPPKQPLYNAAIDYSAPLQQQINPDLIGAHPHAQQHQQQVRQQQQQQQQQQPQQQQQQQQQQTQQQQSQQQQQQQQQQHQPVVSTFQRGNFPQQSHKTMNMMAMADVMSKYQQQQHQQQQQQRQQQHNLQPQQQHATQKGLEGLLLTNTNTSNNNSSSSSSSSISNLIISHNSASNTGNKMQPTWGQSDAISALWGCSSSSSGCSSGSGSQPSLSPTASSNGNDGSKMMLWAAQSSPQNAATLRDGFKELQRQQPPQQQVPQQQPHAASPTASLTSSSSSSNGWSASHYGKPNIWELPGSTGQRTPASSHDIFTDLLCNLSISQDNSSQQASSKADASDVSSNSSSSAGELLEAANIWRFPEYASSQLYMEEPTGGAAACMQLFNDYLNMN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
436	Phosphorylation	LYSDRVRSTSGCNGI ECHHHCCCCCCCCCC	24.86	21082442
438	Phosphorylation	SDRVRSTSGCNGIFS HHHCCCCCCCCCCCC	42.46	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HDC_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HDC_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HDC_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UNK_DROME	unk	physical	14605208
UNK_DROME	unk	physical	25210733

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.