1433E_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: 1433E_DROME
• UniProt AC: P92177
• Protein Name: 14-3-3 protein epsilon
• Gene Name: 14-3-3epsilon
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 262
• Protein Description: Positively regulates Ras-mediated pathways. Acts downstream or parallel to Raf, but upstream of nuclear factors in Ras signaling. Three mutants have been isolated, that suppress the rough eye phenotype caused by mutated Ras1 (sev-Ras1 v12). Inhibits yki activity by restricting its nuclear localization..
• Protein Sequence: MTERENNVYKAKLAEQAERYDEMVEAMKKVASMDVELTVEERNLLSVAYKNVIGARRASWRIITSIEQKEENKGAEEKLEMIKTYRGQVEKELRDICSDILNVLEKHLIPCATSGESKVFYYKMKGDYHRYLAEFATGSDRKDAAENSLIAYKAASDIAMNDLPPTHPIRLGLALNFSVFYYEILNSPDRACRLAKAAFDDAIAELDTLSEESYKDSTLIMQLLRDNLTLWTSDMQAEEVDPNAGDGEPKEQIQDVEDQDVS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
46	Phosphorylation	VEERNLLSVAYKNVI HHHHHHHHHHHHHHH	14.10	22668510
49	Phosphorylation	RNLLSVAYKNVIGAR HHHHHHHHHHHHHHH	10.84	19429919
69	Acetylation	IITSIEQKEENKGAE EEEEHHHHHHCCCHH	54.96	21791702
78	Acetylation	ENKGAEEKLEMIKTY HCCCHHHHHHHHHHH	41.05	21791702
83	Acetylation	EEKLEMIKTYRGQVE HHHHHHHHHHHHHHH	37.89	21791702
91	Acetylation	TYRGQVEKELRDICS HHHHHHHHHHHHHHH	64.29	21791702
139	Phosphorylation	LAEFATGSDRKDAAE HHHHHCCCCHHHHHH	29.86	22817900
208	Phosphorylation	DAIAELDTLSEESYK HHHHHHHCCCHHHCC	44.82	29892262
210	Phosphorylation	IAELDTLSEESYKDS HHHHHCCCHHHCCCH	41.22	19429919
213	Phosphorylation	LDTLSEESYKDSTLI HHCCCHHHCCCHHHH	33.17	19429919
262	Phosphorylation	DVEDQDVS------- CCCCCCCC-------	42.67	19429919

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of 1433E_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of 1433E_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of 1433E_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SH3BG_DROME	Sh3beta	physical	22036573
TNG2_DROME	Tango2	physical	22036573
RS27A_DROME	RpS27A	physical	24292889
ITA1_DROME	mew	genetic	22500634
ITA2_DROME	if	genetic	22500634
1433Z_DROME	14-3-3zeta	genetic	12431373
1433Z_DROME	14-3-3zeta	genetic	17660572
RAS2_DROME	Ras64B	genetic	22500634
FOXO_DROME	foxo	genetic	18665908
RHEB_DROME	Rheb	physical	27151460
YAP1_DROME	yki	physical	26887950
NDE1_DROME	nudE	physical	23987511
TCTP_DROME	Tctp	physical	27151460

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"An integrated chemical, mass spectrometric and computational strategyfor (quantitative) phosphoproteomics: application to Drosophilamelanogaster Kc167 cells.";
Bodenmiller B., Mueller L.N., Pedrioli P.G.A., Pflieger D.,Juenger M.A., Eng J.K., Aebersold R., Tao W.A.;
Mol. Biosyst. 3:275-286(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-262, AND MASSSPECTROMETRY.
PubMed: 17372656