PELI_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PELI_DROME
• UniProt AC: O77237
• Protein Name: Protein pellino
• Gene Name: Pli
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 424
• Protein Description: Scaffold protein involved in the Toll signaling pathway via its interaction with pelle/pll kinase..
• Protein Sequence: MVKRTDGTESPILAEDGGDGHDKPRLRYGELVILGYNGYLPQGDRGRRRSKFVLHKRTEASGVKRSKHYIVQSPQTSKAILDANQHSISYTLSRNQAVIVEYKEDTETDMFQVGRSSESPIDFVVMDTLPGDKKDAKVMQSTISRFACRILVNRCEPAKARIFAAGFDSSRNIFLGEKATKWQDNVEIDGLTTNGVLIMHPKGSFCGGNAKCGLWRECSVGGDVFSLRESRSAQQKGQPIYDECNILQDGTLIDLCGATLLWRSAEGLQHSPTKHDLEKLIDAINAGRPQCPVGLNTLVIPRKVNIGDQVNQPYVYLNCGHVQGHHDWGQDENTGARRCPMCLELGPVVTLCMGLEPAFYVDVGAPTYAFNPCGHMATEKTVKYWANVEIPHGTNGFQAVCPFCATPLDGATGYIKLIFQDNLD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MVKRTDGTESPI ---CCCCCCCCCCCE	32.82	19429919
8	Phosphorylation	MVKRTDGTESPILAE CCCCCCCCCCCEEEC	35.78	19429919
10	Phosphorylation	KRTDGTESPILAEDG CCCCCCCCCEEECCC	19.65	19429919
73	Phosphorylation	SKHYIVQSPQTSKAI CCEEEEECCCHHHHH	14.21	21082442
76	Phosphorylation	YIVQSPQTSKAILDA EEEECCCHHHHHHHC	35.26	21082442
91	Phosphorylation	NQHSISYTLSRNQAV CCCEEEEEECCCEEE	16.09	21082442
297	Phosphorylation	QCPVGLNTLVIPRKV CCCCCCCEEEEECCC	27.69	21082442

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PELI_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PELI_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PELI_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RAGP1_DROME	RanGAP	physical	14605208
ZEST_DROME	z	physical	14605208
RL32_DROME	RpL32	physical	14605208
LCP2_DROME	Lcp2	physical	14605208
TUBE_DROME	tub	physical	24632597
PELI_DROME	Pli	physical	10330490
KPEL_DROME	pll	physical	10330490
KPEL_DROME	pll	physical	24632597

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-10, AND MASSSPECTROMETRY.
PubMed: 18327897