LIN54_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LIN54_DROME
• UniProt AC: A1Z9E2
• Protein Name: Protein lin-54 homolog
• Gene Name: mip120
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 950
• Subcellular Localization: Nucleus .
• Protein Description: Component of the DREAM complex, a multiprotein complex that can both act as a transcription activator or repressor depending on the context. In follicle cells, the complex plays a central role in the site-specific DNA replication at the chorion loci. During development, the complex represses transcription of developmentally controlled E2F target genes..
• Protein Sequence: MDTSGGNLDSLDDTEPLPELSFEDFLEPTSEKSSQHMEIEALDSEEDNIGGEDLADPANDSLNTPQFKKNVVHILEDKRLNSSGLTVLKSHAIKMVTAGGTPPAKAQVTDVKILNKLKPIPSSTLKIGSTTIATKSTPGSITKTLGNLTQIRTKDGQVIFVQKSVPGTQSSTAVTGSPSGGIRRLVAPSGIQKAVLSKGVTMASTGLVKAAVPAKASTSVPGSAITLKGIQPLAGGTAKASTSSTTATTSPSLAQPNKIQVVRTADGKIIKINQAGPSLLVNAKQGTGTTVTPGGSAATSVKLSPSTGNVVLNKPVGQVVVRTETPVKTATGSVASASATPGKMLVQSGGKQILVSNKNIIKLSPNASATSSTTHTTGGQTPSTSSGLHAIQLPGKGGIQYVRVLNNNKSAAGTSATASIPKTVQTQKITVVRPPAATGVPATSTTTSAAAASPAAASKANLAMGNTNKIVMRSMGGSIVPLPSVQTLVSKRALGAISNASKPASAASSSATPSASQELPRKHRLTDLNVQLKQSASVSSEASDSSDAGPEAKKPRYVITMQQGSQKAASQPVQKLINRTANVQRVVSSSTSPSSNSTKKIYNYVQPTGSNGAKYMICNSGVPQSSTSAMRRGYTGYVENKTRRPPPISPQQHRFKQMGPQQQSKHQQLQAQAKQRIRQQQLPTEQSTPIKVEPKLPTLPPGVKANVPAKPLFEVLKPPATAAAAGAVDPLGGMTSRRKHCNCSKSQCLKLYCDCFANGEFCQDCTCKDCFNNLDYEVERERAIRSCLDRNPSAFKPKITAPNSGDMRLHNKGCNCKRSGCLKNYCECYEAKIPCSSICKCVGCRNMEDRPDVDMDSLDGLMGVEGQKKDKAKNKQLNENRANIYFTDDVIEATIMCMISRIVMHEKQNVAVEDMEREVMEEMGESLTQIIAFAKEKQETSQIDESKPSS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
44	Phosphorylation	MEIEALDSEEDNIGG EEEEECCCCCCCCCC	43.67	22668510
83	Phosphorylation	EDKRLNSSGLTVLKS CCCCCCCCCCEEEHH	36.43	22817900
175	Phosphorylation	TQSSTAVTGSPSGGI CCCCEEECCCCCCCC	29.49	29892262
179	Phosphorylation	TAVTGSPSGGIRRLV EEECCCCCCCCEEEE	51.88	21082442
268	Acetylation	VVRTADGKIIKINQA EEECCCCCEEEEEEC	41.63	21791702
304	Phosphorylation	AATSVKLSPSTGNVV CCEEEEECCCCCCEE	15.87	19429919
314	Acetylation	TGNVVLNKPVGQVVV CCCEEECCCCCEEEE	36.60	21791702
348	Phosphorylation	PGKMLVQSGGKQILV CCCEEEEECCEEEEE	41.87	30478224
351	Acetylation	MLVQSGGKQILVSNK EEEEECCEEEEECCC	37.38	21791702
364	Phosphorylation	NKNIIKLSPNASATS CCCEEEECCCCCCCC	15.88	21082442
453	Phosphorylation	TTSAAAASPAAASKA CCCHHHCCHHHHHHC	15.45	21082442
474	Phosphorylation	TNKIVMRSMGGSIVP CCCEEEECCCCCEEE	12.04	21082442
526	Phosphorylation	LPRKHRLTDLNVQLK CCHHHCCCHHHHHHH	38.10	22817900
588	Phosphorylation	ANVQRVVSSSTSPSS CCCEEHHCCCCCCCC	18.73	22817900
591	Phosphorylation	QRVVSSSTSPSSNST EEHHCCCCCCCCCCC	46.75	25749252
592	Phosphorylation	RVVSSSTSPSSNSTK EHHCCCCCCCCCCCC	25.40	25749252
594	Phosphorylation	VSSSTSPSSNSTKKI HCCCCCCCCCCCCEE	41.75	21082442
595	Phosphorylation	SSSTSPSSNSTKKIY CCCCCCCCCCCCEEE	37.88	21082442
649	Phosphorylation	TRRPPPISPQQHRFK CCCCCCCCHHHHHHH	23.56	19429919
688	Phosphorylation	QLPTEQSTPIKVEPK CCCCCCCCCCEECCC	28.82	21082442
804	Phosphorylation	PKITAPNSGDMRLHN CCCCCCCCCCCCCCC	34.80	25749252
857	Phosphorylation	RPDVDMDSLDGLMGV CCCCCHHHHCCHHCC	23.01	19429919

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LIN54_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LIN54_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LIN54_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RBF_DROME	Rbf	physical	15545624
MYB_DROME	Myb	physical	12490953
MYB_DROME	Myb	physical	15545624
E2F2_DROME	E2f2	physical	15545624
TFDP_DROME	Dp	physical	15545624
HDAC1_DROME	Rpd3	physical	15545624
CAF1_DROME	Caf1	physical	12490953
CAF1_DROME	Caf1	physical	15545624

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.