TFDP_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TFDP_DROME
• UniProt AC: Q24318
• Protein Name: Transcription factor Dp
• Gene Name: Dp
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 445
• Subcellular Localization: Nucleus .
• Protein Description: Component of the DREAM complex, a multiprotein complex that can both act as a transcription activator or repressor depending on the context. In follicle cells, the complex plays a central role in the site-specific DNA replication at the chorion loci. During development, the complex represses transcription of developmentally controlled E2F target genes. Can stimulate E2F-dependent transcription..
• Protein Sequence: MAHSTGGTVKTDEVNFFFRNEHGQISKMLKPAQNKSEMEGGKPVAVVYATGSSARNSGSASGIGNVGRMGAFSQMGSQGQFIRLQDNGLSIPKTEAGTTYTTVSAQKTSGAGSGHYDLPLKGDRYVKFTPNPIKMKSKLHAIQSNSLHSMSASSSSVQRKRKPDKAGKGLRHFSMKVCEKVEEKGKTTYNEVADDLVSEEMKNNAYDNNCDQKNIRRRVYDALNVLMAINVISKDKKEIRWIGLPANSTETFLALEEENCQRRERIKQKNEMLREMIMQHVAFKGLVERNKRNESQGVVPSPNASIQLPFIIVNTHKSTKINCSVTNDKSEYIFKFDKTFEMHDDIEVLKRMGFLLGLDKGECTPENIERVKSWVPPNLAKYVEAYGTGKTGENMYESDDEDNEFNGYLESANESQGFAQHSAQHTTDGEFKLEMDDDELDDDID

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
30	Acetylation	GQISKMLKPAQNKSE CCHHHCCCCCCCHHH	34.50	21791702
42	Acetylation	KSEMEGGKPVAVVYA HHHHCCCCEEEEEEE	47.37	21791702
57	Phosphorylation	TGSSARNSGSASGIG CCCCHHCCCCCCCCC	28.68	21082442
398	Phosphorylation	TGENMYESDDEDNEF CCCCCCCCCCCCCCC	32.64	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TFDP_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TFDP_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TFDP_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
E2F1_DROME	E2f	physical	14605208
TTC19_DROME	Ttc19	physical	15575970
API5_DROME	Aac11	genetic	17112319
RBF_DROME	Rbf	physical	8675008
ORC2_DROME	Orc2	physical	11231579
E2F1_DROME	E2f	physical	25242320
E2F1_DROME	E2f	physical	8022787
E2F1_DROME	E2f	physical	8675008

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-398, AND MASSSPECTROMETRY.
PubMed: 18327897