dbPTM

API5_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	API5_DROME
UniProt AC	Q9V431
Protein Name	Apoptosis inhibitor 5 homolog
Gene Name	Aac11
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	536
Subcellular Localization	Nucleus.
Protein Description	Antiapoptotic factor. Also known to efficiently suppress E2F1-induced apoptosis..
Protein Sequence	MDNIERLYKCYEILSEAGDKISEHVDEYKEILKAVKGTSKEKRLASQFIGNFFKHFPDLADTAIDAQFDLCEDDDTQIRRQAIKDLPKLCQGNADATIRVGDTLAQLLILDDPTELQQVNNSLLAIIKLDTKSSIAGLFQQISTGDETTRERCLKFIATKLLTMGPTVITKEIEDYIVEEIKKALQDVTADEFHLCMTILGATKLGSTITGHAELVKLATEQAELNNTDADIIAVDDEVVERFIQCASAAAPYFSKTIKSTAFVAHVCDKLLPIKTWNMIATAVSQDQIQLRLLKVFAEMITNTDKLDNASERINAVYNVLLEYMPLPKLSDEDLGDTPPSFQFSHAECLLYALHTLGKNHPNSLSFVEDAEKLKDFRARLQYLARGTQGYIKKLEESLKGKTGEELKTEENQLKQTALKTTSNINILIRDLFHSPPIFKHDIVLSWIVPKNNKLGKRHAPITFGEKAAANGKDKDQEPEKKSRPSNDQKFYSPPSGKYSNKVNQSYGNNNRTRQRGGGGGGGSGGGYRNRRFNKY

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
486	Phosphorylation	PEKKSRPSNDQKFYS CCCCCCCCCCCCCCC	52.51	22817900
493	Phosphorylation	SNDQKFYSPPSGKYS CCCCCCCCCCCCCCC	33.20	19429919
498	Acetylation	FYSPPSGKYSNKVNQ CCCCCCCCCCCCCCH	50.25	21791702
506	Phosphorylation	YSNKVNQSYGNNNRT CCCCCCHHCCCCCCC	29.78	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of API5_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of API5_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of API5_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
DX39B_DROME	Hel25E	physical	14605208

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of API5_DROME

Related Literatures of Post-Translational Modification