MYB_DROME - dbPTM
MYB_DROME - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MYB_DROME
UniProt AC P04197
Protein Name Myb protein
Gene Name Myb
Organism Drosophila melanogaster (Fruit fly).
Sequence Length 657
Subcellular Localization Nucleus. Chromosome.
Protein Description DNA-binding protein that specifically recognizes the sequence 5'-YAAC[GT]G-3'. Component of the DREAM complex, a multiprotein complex that can both act as a transcription activator or repressor depending on the context. In follicle cells, the complex plays a central role in the site-specific DNA replication at the chorion loci. During development, the complex represses transcription of developmentally controlled E2F target genes..
Protein Sequence MASASTENGEELMNYGSNSDSEESEYSENEDTQVCDKDSQQNSNADSGYPLDSPELQDSKTTGQKGQNKSGKTSIGAVHPNYGFGKRWSKSEDVLLKQLVETHGENWEIIGPHFKDRLEQQVQQRWAKVLNPELIKGPWTRDEDDMVIKLVRNFGPKKWTLIARYLNGRIGKQCRERWHNHLNPNIKKTAWTEKEDEIIYQAHLELGNQWAKIAKRLPGRTDNAIKNHWNSTMRRKYDVERRSVNASGSDLKSSRTHLITLIKSGGISKCMNNMQHNKESGGEAVNKSENADGASVTAVKGGDLAQESQDDHQKGSNLAHLSMQHLIKLTMPRQTPIILKRTRKHIPETHHQAGCSSSETFNQEEAAGNARSRPPSSPVISPIKSLPFSPSHFLKSPCLTTFEDMDLRASTPVTKVYNRVGMEIKKEMETSSIETPHKSQLGPRTPTPFKKALAAIGKKRDGRRYEPSSPSSLVEDLAEIIHEEHLSNSLTANNSKMMGAADQNSTLSTEYNAQSPPHMKRARKSLLSTWSSNHPYNAGSAKRIQPFETETPSKFLTSPGDILKDTLCSEQDLPFDEGRKENRPFHNRRINKYRGGLTYDHVIDPKWARVACGKSRDQMFMEEQAYACLKNLSCISRSLNFEKQKCLVNSFDRFGSL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
53PhosphorylationDSGYPLDSPELQDSK
CCCCCCCCHHHCCCC		28.1419429919
59PhosphorylationDSPELQDSKTTGQKG
CCHHHCCCCCCCCCC		20.9519429919
376PhosphorylationNARSRPPSSPVISPI
CCCCCCCCCCCCCCC		50.3719429919
377PhosphorylationARSRPPSSPVISPIK
CCCCCCCCCCCCCCC		29.0319429919
381PhosphorylationPPSSPVISPIKSLPF
CCCCCCCCCCCCCCC		22.3219429919
385PhosphorylationPVISPIKSLPFSPSH
CCCCCCCCCCCCHHH		41.8323607784
389PhosphorylationPIKSLPFSPSHFLKS
CCCCCCCCHHHHCCC		24.4519429919
391PhosphorylationKSLPFSPSHFLKSPC
CCCCCCHHHHCCCCC		26.1819429919
396PhosphorylationSPSHFLKSPCLTTFE
CHHHHCCCCCCCCHH		24.0023607784
400PhosphorylationFLKSPCLTTFEDMDL
HCCCCCCCCHHHCCH		35.8323607784
401PhosphorylationLKSPCLTTFEDMDLR
CCCCCCCCHHHCCHH		16.4523607784
410PhosphorylationEDMDLRASTPVTKVY
HHCCHHCCCCCHHHH		27.1527626673
445PhosphorylationKSQLGPRTPTPFKKA
HHHCCCCCCCHHHHH		34.3519429919
447PhosphorylationQLGPRTPTPFKKALA
HCCCCCCCHHHHHHH		40.5219429919
469PhosphorylationGRRYEPSSPSSLVED
CCCCCCCCCHHHHHH		39.2421082442
515PhosphorylationSTEYNAQSPPHMKRA
CHHCCCCCCHHHHHH		37.6822668510
551PhosphorylationIQPFETETPSKFLTS
CCCCCCCCCHHHCCC		40.0425749252
557PhosphorylationETPSKFLTSPGDILK
CCCHHHCCCHHHHHH		35.6929892262
558PhosphorylationTPSKFLTSPGDILKD
CCHHHCCCHHHHHHH		29.0922817900
566PhosphorylationPGDILKDTLCSEQDL
HHHHHHHCCCCCCCC		28.2522817900
569PhosphorylationILKDTLCSEQDLPFD
HHHHCCCCCCCCCCC		41.2122817900
638PhosphorylationNLSCISRSLNFEKQK
CHHHHHHHCCCCHHH		22.3727626673
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MYB_DROME !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MYB_DROME !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MYB_DROME !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SCN60_DROMENaCP60Ephysical
14605208
CDK1_DROMEcdc2genetic
9512517
CDK1_DROMEcdc2genetic
11847115
CCNB_DROMECycBgenetic
11847115
MPIP_DROMEstggenetic
9512517
MPIP_DROMEstggenetic
11847115
RBF_DROMERbfphysical
15545624
E2F2_DROMEE2f2physical
15545624
ORC1_DROMEOrc1physical
12490953
TFDP_DROMEDpphysical
15545624
LIN54_DROMEmip120physical
12490953
LIN54_DROMEmip120physical
15545624
LIN54_DROMEmip120physical
21969598
ORC2_DROMEOrc2physical
12490953
CAF1_DROMECaf1physical
12490953
CAF1_DROMECaf1physical
15545624
CAF1_DROMECaf1physical
21969598
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MYB_DROME

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-381; SER-389; SER-396;THR-445; THR-447; THR-557; SER-558; THR-566 AND SER-569, AND MASSSPECTROMETRY.

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