PRP39_DROME - dbPTM
PRP39_DROME - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PRP39_DROME
UniProt AC Q7KRW8
Protein Name Pre-mRNA-processing factor 39
Gene Name CG1646
Organism Drosophila melanogaster (Fruit fly).
Sequence Length 1066
Subcellular Localization Nucleus.
Protein Description Involved in pre-mRNA splicing..
Protein Sequence MASEGENVVMESPGRRTRSGRKAASPAASLPTRSTRRTSKRNVQLSDHEEEAEEQVVMVQEEEEPFRGTNTAEAPALEPQFEETQHQIEDDVEMLPAEAAGVDEKSSSFPFGTVAELHSETSDDIKETRGQAGVDTLLASLAGDNANSLPSVGGNDESDNVKKADFEYNVDSLQPQMEKMNSSEDSSSQHAIAEDLADADTSNATIVNTEIVSEDELPLPSKPEINDAEEVSDEELPAPQRAELPEDAEVISEDELPASNNNNTATEPKAPLKRKAENESVKSTEDKDASSHESSTKDKSSEQYNPGSPTSESNDAQPSEKKLKVEESEPKEKKKEKERDKDKEKDKDKDNNKDKEKERKKLPDLDKYWRAVKEDSTDFTGWTYLLQYVDNESDAEAAREAYDTFLSHYPYCYGYWRKYADYEKRKGIKANCYKVFERGLEAIPLSVDLWIHYLMHVKSNHGDDETFVRSQYERAVKACGLEFRSDKLWDAYIRWENESKRYHRVVQIYDRLLAIPTQGYNGHFDNFQDLINQHDVTITLANEEVIRLRKDFHERQQSKSSKSSSKHRRDSSSSSKDKDSKEREREKDKDKDKDKDKEKRETVGGGVGKSPKDTSETQVDESDSTTDLTTESESSHAASKPAMQIDFSDLSTLNDEEVVSIRDRAISARRKVHKLTVSAVTARWSFEEGIKRPYFHVKPLERAQLKNWKDYLDFEIEKGDRERVLVLFERCLIACALYDEFWLKMLRYLESLEDQSGVVDLVRDVYRRACRIHHPDKPSLHLMWAAFEECQMNFDDAAEILQRIDQRCPNLLQLSYRRINVERRRGALDKCRELYKHYIESTKNKGIAGSLAIKYARFLNKICHDLDAGLAALQQALERDPANTRVALQMIDLCLQRPKVDEQEVVEIMDKFMARADIEPDQKVLFAQRKVEFLEDFGSTARGLQDAQRALQQALTKAKEAQKKSDGSPSRKNSSSSKEGPVPTGSAAAAYNNGGSAAAVAGYNYGAANPYYGQQNTAAAYPSQTPQQASYDSYYNQWGYGSGGASANSGGSGYNYGQWSGYGNYY
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
12PhosphorylationGENVVMESPGRRTRS
CCCEEECCCCCCCCC		17.9823607784
25PhosphorylationRSGRKAASPAASLPT
CCCCCCCCCCCCCCC		21.6728490779
46PhosphorylationSKRNVQLSDHEEEAE
CCCCCCCCCCHHHHH		21.6022817900
106PhosphorylationAAGVDEKSSSFPFGT
HCCCCCCCCCCCCCC		29.2127794539
107PhosphorylationAGVDEKSSSFPFGTV
CCCCCCCCCCCCCCH		47.2527794539
119PhosphorylationGTVAELHSETSDDIK
CCHHHHCCCCCCHHH		56.0122668510
121PhosphorylationVAELHSETSDDIKET
HHHHCCCCCCHHHHH		40.2322668510
122PhosphorylationAELHSETSDDIKETR
HHHCCCCCCHHHHHH		29.2722668510
148PhosphorylationLAGDNANSLPSVGGN
HHCCCCCCCCCCCCC		38.9722817900
151PhosphorylationDNANSLPSVGGNDES
CCCCCCCCCCCCCCC		38.3922817900
158PhosphorylationSVGGNDESDNVKKAD
CCCCCCCCCCCCHHH		37.0322817900
232PhosphorylationINDAEEVSDEELPAP
CCCHHHCCCCCCCCC		42.4519429919
252PhosphorylationPEDAEVISEDELPAS
CCCCCCCCCCCCCCC		44.1419429919
290PhosphorylationSTEDKDASSHESSTK
CCCCCCCCCCCCCCC		42.2219429919
291PhosphorylationTEDKDASSHESSTKD
CCCCCCCCCCCCCCC		32.7519429919
308PhosphorylationSEQYNPGSPTSESND
CCCCCCCCCCCCCCC		26.6821082442
310PhosphorylationQYNPGSPTSESNDAQ
CCCCCCCCCCCCCCC		46.9919429919
311PhosphorylationYNPGSPTSESNDAQP
CCCCCCCCCCCCCCC		42.2719429919
313PhosphorylationPGSPTSESNDAQPSE
CCCCCCCCCCCCCCH		39.5119429919
558PhosphorylationDFHERQQSKSSKSSS
HHHHHHHHCCCCCCC		26.6022817900
572PhosphorylationSKHRRDSSSSSKDKD
CCCCCCCCCCCCCCH		38.2330478224
602PhosphorylationKDKEKRETVGGGVGK
CCHHHHHCCCCCCCC		28.6022817900
610PhosphorylationVGGGVGKSPKDTSET
CCCCCCCCCCCCCCC		31.1119429919
968PhosphorylationAQKKSDGSPSRKNSS
HHHHCCCCCCCCCCC		25.3719429919
970PhosphorylationKKSDGSPSRKNSSSS
HHCCCCCCCCCCCCC		58.5519429919
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PRP39_DROME !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PRP39_DROME !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PRP39_DROME !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ATNA_DROMEAtpalphaphysical
14605208
SXL_DROMESxlphysical
14605208
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PRP39_DROME

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-122; SER-148; SER-158;SER-308 AND SER-313, AND MASS SPECTROMETRY.
"An integrated chemical, mass spectrometric and computational strategyfor (quantitative) phosphoproteomics: application to Drosophilamelanogaster Kc167 cells.";
Bodenmiller B., Mueller L.N., Pedrioli P.G.A., Pflieger D.,Juenger M.A., Eng J.K., Aebersold R., Tao W.A.;
Mol. Biosyst. 3:275-286(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-252, AND MASSSPECTROMETRY.

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