ATNA_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ATNA_DROME
• UniProt AC: P13607
• Protein Name: Sodium/potassium-transporting ATPase subunit alpha
• Gene Name: Atpalpha
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 1041
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein.
• Protein Description: This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients..
• Protein Sequence: MALRSDYEHGRADSYRVATVIATDDDNRTADGQYKSRRKMPAKVNKKENLDDLKQELDIDFHKISPEELYQRFQTHPENGLSHAKAKENLERDGPNALTPPKQTPEWVKFCKNLFGGFAMLLWIGAILCFVAYSIQASTSEEPADDNLYLGIVLSAVVIVTGIFSYYQESKSSKIMESFKNMVPQFATVIREGEKLTLRAEDLVLGDVVEVKFGDRIPADIRIIEARNFKVDNSSLTGESEPQSRGAEFTHENPLETKNLAFFSTNAVEGTAKGVVISCGDHTVMGRIAGLASGLDTGETPIAKEIHHFIHLITGVAVFLGVTFFVIAFILGYHWLDAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMASKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIIEADTTEDQSGVQYDRTSPGFKALSRIATLCNRAEFKGGQDGVPILKKEVSGDASEAALLKCMELALGDVMNIRKRNKKIAEVPFNSTNKYQVSIHETEDTNDPRYLLVMKGAPERILERCSTIFINGKEKVLDEEMKEAFNNAYMELGGLGERVLGFCDFMLPSDKYPNGFKFNTDDINFPIDNLRFVGLMSMIDPPRAAVPDAVAKCRSAGIKVIMVTGDHPITAKAIAKSVGIISEGNETVEDIAQRLNIPVSEVNPREAKAAVVHGAELRDVSSDQLDEILRYHTEIVFARTSPQQKLIIVEGCQRMGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEISPFLAFILCDIPLPLGTVTILCIDLGTDMVPAISLAYEHAEADIMKRPPRDPFNDKLVNSRLISMAYGQIGMIQAAAGFFVYFVIMAENGFLPKKLFGIRKMWDSKAVNDLTDSYGQEWTYRDRKTLEYTCHTAFFISIVVVQWADLIICKTRRNSIFQQGMRNWALNFGLVFETVLAAFLSYCPGMEKGLRMYPLKLVWWFPAIPFALAIFIYDETRRFYLRRNPGGWLEQETYY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MALRSDYEHGRADS -CCCCCCCCCCCCCC	15.86	19429919
15	Phosphorylation	EHGRADSYRVATVIA CCCCCCCEEEEEEEE	15.06	18281928
29	Phosphorylation	ATDDDNRTADGQYKS EECCCCCCCCCCCCC	35.04	22668510
34	Phosphorylation	NRTADGQYKSRRKMP CCCCCCCCCCCCCCC	19.23	19429919
70	Phosphorylation	KISPEELYQRFQTHP HCCHHHHHHHHHHCC	10.83	25749252
244	Phosphorylation	TGESEPQSRGAEFTH CCCCCCCCCCCCCCC	43.31	27794539
387	Phosphorylation	EAVETLGSTSTICSD HHHHHHCCCCCCCCC	23.46	27794539
466	Phosphorylation	PILKKEVSGDASEAA CEEEEECCCCHHHHH	31.86	27794539
502	Phosphorylation	IAEVPFNSTNKYQVS EEECCCCCCCCEEEE	33.46	27794539
503	Phosphorylation	AEVPFNSTNKYQVSI EECCCCCCCCEEEEE	36.51	27794539
671	Phosphorylation	QRLNIPVSEVNPREA HHCCCCHHHCCHHHH	30.39	27794539
692	Phosphorylation	GAELRDVSSDQLDEI CCCHHCCCHHHHHHH	32.27	19429919

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ATNA_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ATNA_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ATNA_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CATL_DROME	Cp1	physical	14605208
RL36_DROME	RpL36	physical	14605208
SAP47_DROME	Sap47	physical	14605208
ATPB2_DROME	nrv2	physical	22036573
VATA2_DROME	Vha68-2	physical	22036573
ACADM_DROME	CG12262	physical	22036573
OST48_DROME	Ost48	physical	22036573
ATC1_DROME	Ca-P60A	physical	22036573
DX39B_DROME	Hel25E	physical	22036573
RS27A_DROME	RpS27A	physical	24292889
ADT_DROME	sesB	genetic	15281071
SCNA_DROME	para	genetic	16272407
SCNA_DROME	para	genetic	15281071

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.