ATPB2_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ATPB2_DROME
• UniProt AC: Q24048
• Protein Name: Sodium/potassium-transporting ATPase subunit beta-2
• Gene Name: nrv2
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 323
• Subcellular Localization: Cell membrane ; Single-pass type II membrane protein .
• Protein Description: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane..
• Protein Sequence: MPTITEDCIDGFQQYYSRPPERPKKKSLKQMVYDSEDNSYFGRSMDSWAKIGIFYVAFYGVLAALVAICMWAFFQTLDPRIPKWTLDRSLIGTNPGLGFRPLPPVDNVESTLIWYKGTQHENYKHWTDSLDDFLAVYKVPGLTPGRGQNIYNCDYNQPPPKGQVCDVDIKTWSPCTKENNYSYHKSAPCIFLKLNKIYGWIPEYYNRSNDLPANMPASLKTYIAEVEKTQPEKLNTIWVSCEGENPADQENIGAVNYLPIRGFPGYFYPYQNSEGYLSPLVAVHFQRPKRGIIINVECRAWARNIIHDRKERIGSVHYELLID

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8 (in isoform 2)	Phosphorylation	-	2.19	23607784
10 (in isoform 2)	Phosphorylation	-	59.18	23607784
180	N-linked_Glycosylation	SPCTKENNYSYHKSA CCCCCCCCCCCCCCC	28.37	-
206	N-linked_Glycosylation	GWIPEYYNRSNDLPA HCCHHHHCCCCCCCC	39.75	17893096

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ATPB2_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ATPB2_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ATPB2_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
41_DROME	cora	physical	12782686
NRX4_DROME	Nrx-IV	physical	12782686

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"Identification of N-glycosylated proteins from the central nervoussystem of Drosophila melanogaster.";
Koles K., Lim J.-M., Aoki K., Porterfield M., Tiemeyer M., Wells L.,Panin V.;
Glycobiology 17:1388-1403(2007).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-206, AND MASSSPECTROMETRY.
PubMed: 17893096