dbPTM

NEMO_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	NEMO_DROME
UniProt AC	Q9GYV5
Protein Name	NF-kappa-B essential modulator
Gene Name	key
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	387
Subcellular Localization	Cytoplasm. Nucleus.
Protein Description	Essential signaling component in transmitting the lipopolysaccharide (LPS) signal leading to cact degradation, which is required for NF-kappa-B (Rel) activation. Required for antibacterial immune response..
Protein Sequence	MSDEESFVILGSSPCSSLMPDSSLRSDVCGNAQEAEETVASTSTQPPTVNCIPVSITASQQQHKSLDSGSSQQQSLATSFIMGEIQSDVLKNSVYSQFPSLCSLQGSAEEVVKLQNMMTEYLALKSTLDKVNQTMLNYHNLTQQWRQEAADREHQYKEHVKECQAQIAILRVENQELKRDLETKIEQIEGVHTIRLKEQDELRKSVSEKQSLIDNMRVEIDKLKQLNHSFEFVPEYATESKSQELIKKMQLDINELKARDIQKQEVIKGLQIQNDIYRRDFEMERADREKNAGEKDQYLMDLRSLQRRNQELIEALAESHKASKACSTASPLSSSRSNLREEQRPILDPTGASSRTSDTTLRCPICSKSFNALSVLQSHVNDCLDKN

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
57	Phosphorylation	NCIPVSITASQQQHK EEEEEEEECCHHHHH	16.86	21082442
229	Phosphorylation	KLKQLNHSFEFVPEY HHHHCCCCCCCCHHH	25.95	22668510
330	Phosphorylation	SKACSTASPLSSSRS HHHHCCCCCCCCCCC	26.85	25749252
334	Phosphorylation	STASPLSSSRSNLRE CCCCCCCCCCCCCCH	37.14	27626673
335	Phosphorylation	TASPLSSSRSNLREE CCCCCCCCCCCCCHH	36.03	22668510

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of NEMO_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of NEMO_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of NEMO_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
IKKB_DROME	ird5	physical	11018014
NACA_DROME	Nacalpha	physical	23749869
HSP68_DROME	Hsp68	physical	23749869
MED14_DROME	MED14	physical	23749869
HSP7A_DROME	Hsc70-1	physical	23749869
IKKB_DROME	ird5	physical	23749869
REF2P_DROME	ref(2)P	physical	23749869
CH60C_DROME	Hsp60C	physical	23749869
RUVB1_DROME	pont	physical	23749869
TCPG_DROME	Cctgamma	physical	23749869
TBA1_DROME	alphaTub84B	physical	23749869
TBA3_DROME	alphaTub84D	physical	23749869
TBA2_DROME	alphaTub85E	physical	23749869
RL22_DROME	RpL22	physical	23749869
EF2_DROME	EF2	physical	23749869
PRDX1_DROME	Jafrac1	physical	23749869
RS28_DROME	RpS28b	physical	23749869
RUVB2_DROME	rept	physical	23749869
IF2A_DROME	eIF-2alpha	physical	23749869
HSP7E_DROME	Hsc70-5	physical	23749869
S39AD_DROME	Zip99C	physical	23749869
LIG_DROME	lig	physical	23749869
CUP_DROME	cup	physical	23749869
ANLN_DROME	scra	physical	23749869
ZASP_DROME	Zasp52	physical	23749869
EF1A1_DROME	Ef1alpha48D	physical	23749869
EF1A2_DROME	Ef1alpha100E	physical	23749869
MA205_DROME	Map205	physical	23749869
MOC2B_DROME	Mocs2	physical	23749869
CATL_DROME	Cp1	physical	23749869
VRET_DROME	vret	physical	23749869
ANKHM_DROME	mask	physical	23749869
NU153_DROME	Nup153	physical	23749869
CP190_DROME	Cp190	physical	23749869
Y2138_DROME	CG32138	physical	23749869
BCL9_DROME	lgs	physical	23749869
CATA_DROME	Cat	physical	23749869
TBB3_DROME	betaTub60D	physical	23749869
MIC60_DROME	CG6455	physical	23749869
SMD2_DROME	SmD2	physical	23749869
RS17_DROME	RpS17	physical	23749869
NH2L1_DROME	hoip	physical	23749869
NEMO_DROME	key	physical	23749869
HSP7D_DROME	Hsc70-4	physical	23749869
ADT_DROME	sesB	physical	23749869
SODC_DROME	Sod	physical	23749869
ATPA_DROME	blw	physical	23749869
JUPIT_DROME	Jupiter	physical	23749869
RS3_DROME	RpS3	physical	23749869
TBB1_DROME	betaTub56D	physical	23749869
SOYB_DROME	SoYb	physical	23749869
CH60_DROME	Hsp60	physical	23749869
RS20_DROME	RpS20	physical	23749869
STIM_DROME	Stim	physical	23749869
Y3800_DROME	CG3800	physical	23749869
HCD2_DROME	scu	physical	23749869
RS16_DROME	RpS16	physical	23749869
HCF_DROME	Hcf	physical	23749869
1433Z_DROME	14-3-3zeta	physical	23749869
CADF_DROME	tsr	physical	23749869
CREBB_DROME	CrebB	physical	23749869
RS10B_DROME	RpS10b	physical	23749869
RL7A_DROME	RpL7A	physical	23749869
MSL3_DROME	msl-3	physical	23749869
TAF6_DROME	Taf6	physical	23749869

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of NEMO_DROME

Related Literatures of Post-Translational Modification