dbPTM

HSP7E_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	HSP7E_DROME
UniProt AC	P29845
Protein Name	Heat shock 70 kDa protein cognate 5
Gene Name	Hsc70-5
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	686
Subcellular Localization
Protein Description
Protein Sequence	MLRVPKFLPRLARQAGVVPSHMSGASSMFRNLPGASNGISSQLRYKSGEVKGAVIGIDLGTTNSCLAVMEGKQAKVIENAEGARTTPSHVAFTKDGERLVGMPAKRQAVTNSANTFYATKRLIGRRFDDPEVKKDITNLSYKVVKASNGDAWVSSTDGKVYSPSQIGAFILMKMKETAEAYLNTPVKNAVVTVPAYFNDSQRQATKDAGQIAGLNVLRVINEPTAAALAYGMDKTEDKIIAVYDLGGGTFDISILEIQKGVFEVKSTNGDTLLGGEDFDNHIVNFLVAEFKKDSGIDIRKDNIAMQRLKEAAEKAKCELSSSQQTDINLPYLTMDAAGPQHMNLKLTRSKLESLVGDLIKRTIQPCQKALSDAEVSKSEIGEVLLVGGMTRMPKVQSTVQELFGRQPSRSVNPDEAVAVGAAVQGGVLAGDVTDVLLLDVTPLSLGIETLGGVFTRLISRNTTIPTKKSQVFSTASDGQTQVEIKVHQGEREMANDNKLLGSFTLVGIPPAPRGVPQIEVVFDIDANGIVHVSAKDKGTGKEQQIVIQSSGGLSKDEIENMIKKAEEYATADKQKRELIEIVNQGESIVHDTETKMEEFKSQLPAEECEKLKKEIADLRTLLANKETADLEEVRKATSSLQQSSLKLFELAYKKMSAERESNAGAGSSDSSSSSDTSGEAKKEEKN

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
86	Phosphorylation	NAEGARTTPSHVAFT CCCCCCCCCCCEEEE	19.76	22817900
94	Acetylation	PSHVAFTKDGERLVG CCCEEEECCCCEECC	58.23	21791702
133	Acetylation	RFDDPEVKKDITNLS CCCCHHHHHHHHHEE	42.96	21791702
142	Acetylation	DITNLSYKVVKASNG HHHHEEEEEEECCCC	36.86	21791702
184	Phosphorylation	TAEAYLNTPVKNAVV HHHHHHCCCCCCEEE	27.19	22817900
234	Acetylation	ALAYGMDKTEDKIIA HHHHCCCCCCCEEEE	44.94	21791702
353	Phosphorylation	LTRSKLESLVGDLIK CCHHHHHHHHHHHHH	38.50	19429919
360	Acetylation	SLVGDLIKRTIQPCQ HHHHHHHHHHCHHHH	51.27	21791702
397	Phosphorylation	TRMPKVQSTVQELFG CCCHHHHHHHHHHHC	33.27	21082442
600	Acetylation	ETKMEEFKSQLPAEE HHHHHHHHHCCCHHH	40.34	21791702
613	Acetylation	EECEKLKKEIADLRT HHHHHHHHHHHHHHH	65.86	21791702
653	Acetylation	KLFELAYKKMSAERE HHHHHHHHHHHHHHH	36.07	21791702

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of HSP7E_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of HSP7E_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of HSP7E_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
VPS18_DROME	dor	genetic	24998521
KAPC_DROME	Pka-C1	genetic	24998521

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of HSP7E_DROME

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos."; Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.; J. Proteome Res. 7:1675-1682(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-86, AND MASSSPECTROMETRY.	18327897 [Abstract]