dbPTM

IKKB_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	IKKB_DROME
UniProt AC	Q9VEZ5
Protein Name	Inhibitor of nuclear factor kappa-B kinase subunit beta {ECO:0000305}
Gene Name	IKKbeta {ECO:0000312\|FlyBase:FBgn0024222}
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	751
Subcellular Localization	Cytoplasm.
Protein Description	Required for the activation of the NF-kappa-B factor Relish (Rel) by acting as an essential signaling component in transmitting the lipopolysaccharide (LPS) signal leading to cact degradation, which is required for direct activation of Rel. Phosphorylates inhibitors of NF-kappa-B (cact) thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the NF-kappa-B inhibitor. Essential for antibacterial immune response..
Protein Sequence	MITVVFCFSDCHGGIQILGRMSSVNKIKLNENNKMHSFGNWERCRNLGEGGFGLVIHWRNRTTGREIATKHIKEMGALSADQQVKLSERWNKELNWSRQFKNFPHIVAGVDIEDPDFLEYLNGMFSAKLPVIVLEYCNGGDVRKRLQSPENANGLTEFEVRQILGALRKALHFLHSQCGICHRDLKPDNIVIQRGVDGKKIYKLTDFGLARGTPDQTMVQSVVGTRHYYAPEVVENGFYNSTVDLWSFGVIAYELVTGELPFIPHQTLKNIILNLIKKPAKCIAITEDPEDNTRFVNQFELPQTHHLSRPWAAQFTKWLASPLNSNYKERGQLAANNVPVVFADLDKILNMNVLTIFAVNNCERLEYAVSAEMTMKDLIALIVLDTGMDEKELYFVLPTSHPHKTITPKSTPLQLYVEEWSDTSKDSRKWTKRSNPPVMLYIFQVKKECDYKIPEPILSILSRKFIANKFKTKERWLQKRVVLDMLYVLTKEQARYEMLVSGINERALSLEDEMMENSFIDSIDKQRIIISFAYDQLTSLLKEAQAKIPSRQLISSAQWEKLNRNYNFIIQSAKSIRSFLEACLREAKDMVKTTNQLRKEVCEKDLFDCARFYKKYLCNGAIISPSELNNDAEEFAKSRFKLYNEGEARHLPKSIDHMHYLYFKTKESIPVLLQQFCDIKKEIFQINLQMLMSASSTPPPKLELSAAMDRLAISSGSPSSDPFDSLRTINAIEEAERINNILVNEMKIDHY

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
202	Phosphorylation	GVDGKKIYKLTDFGL CCCCCEEEEECHHCC	14.61	18327897
221	Phosphorylation	PDQTMVQSVVGTRHY CCHHHHHHHCCCCCC	13.83	-
225	Phosphorylation	MVQSVVGTRHYYAPE HHHHHCCCCCCCCCH	11.58	10636911

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of IKKB_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of IKKB_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of IKKB_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CACT_DROME	cact	physical	10636911
NEMO_DROME	key	physical	11018014
NEMO_DROME	key	physical	22036573
FOSLD_DROME	kay	physical	23749869
FOSLA_DROME	kay	physical	23749869
TCPA_DROME	T-cp1	physical	23749869
BCL9_DROME	lgs	physical	23749869
RL24_DROME	RpL24	physical	23749869
NU214_DROME	Nup214	physical	23749869
CATA_DROME	Cat	physical	23749869
CP190_DROME	Cp190	physical	23749869
NU153_DROME	Nup153	physical	23749869
VRET_DROME	vret	physical	23749869
ANKHM_DROME	mask	physical	23749869
MOC2B_DROME	Mocs2	physical	23749869
MA205_DROME	Map205	physical	23749869
TAF6_DROME	Taf6	physical	23749869
ANLN_DROME	scra	physical	23749869
ZASP_DROME	Zasp52	physical	23749869
LIG_DROME	lig	physical	23749869
CUP_DROME	cup	physical	23749869
S39AD_DROME	Zip99C	physical	23749869
HSP7E_DROME	Hsc70-5	physical	23749869
RUVB2_DROME	rept	physical	23749869
EF2_DROME	EF2	physical	23749869
PRDX1_DROME	Jafrac1	physical	23749869
TBA2_DROME	alphaTub85E	physical	23749869
RL22_DROME	RpL22	physical	23749869
TBA1_DROME	alphaTub84B	physical	23749869
TBA3_DROME	alphaTub84D	physical	23749869
TCPG_DROME	Cctgamma	physical	23749869
RUVB1_DROME	pont	physical	23749869
CH60C_DROME	Hsp60C	physical	23749869
CH60_DROME	Hsp60	physical	23749869
RS20_DROME	RpS20	physical	23749869
STIM_DROME	Stim	physical	23749869
Y3800_DROME	CG3800	physical	23749869
HCD2_DROME	scu	physical	23749869
ATC1_DROME	Ca-P60A	physical	23749869
RS16_DROME	RpS16	physical	23749869
HCF_DROME	Hcf	physical	23749869
SODC_DROME	Sod	physical	23749869
ATPA_DROME	blw	physical	23749869
HSP7D_DROME	Hsc70-4	physical	23749869
SOYB_DROME	SoYb	physical	23749869
TBB1_DROME	betaTub56D	physical	23749869
RS3_DROME	RpS3	physical	23749869
JUPIT_DROME	Jupiter	physical	23749869
RL5_DROME	RpL5	physical	23749869
NCD_DROME	ncd	physical	23749869
Y2138_DROME	CG32138	physical	23749869
CTBP_DROME	CtBP	physical	23749869
HSP7C_DROME	Hsc70-3	physical	23749869
NONA_DROME	nonA	physical	23749869
RL13_DROME	RpL13	physical	23749869
MSL3_DROME	msl-3	physical	23749869
RING1_DROME	Sce	physical	23749869
RL23_DROME	RpL23	physical	23749869
NH2L1_DROME	hoip	physical	23749869
RL7A_DROME	RpL7A	physical	23749869
RS17_DROME	RpS17	physical	23749869
CREBB_DROME	CrebB	physical	23749869
TBB3_DROME	betaTub60D	physical	23749869
IKKB_DROME	ird5	physical	23749869
NEMO_DROME	key	physical	23749869
CACT_DROME	cact	physical	23749869
SPTCA_DROME	alpha-Spec	physical	23749869
DORS_DROME	dl	physical	23749869
HSP7A_DROME	Hsc70-1	physical	23749869
TBB2_DROME	betaTub85D	physical	23749869
AGO2_DROME	AGO2	physical	23749869
RL11_DROME	RpL11	physical	23749869
RL9_DROME	RpL9	physical	23749869
CYC1_DROME	Cyt-c-d	physical	23749869
PSN_DROME	Psn	physical	23749869
HSP72_DROME	Hsp70Ba	physical	23749869
HSP74_DROME	Hsp70Bbb	physical	23749869
CO4A1_DROME	Cg25C	physical	23749869
RS19A_DROME	RpS19a	physical	23749869
SLEL_DROME	CG12592	physical	23749869
HSP68_DROME	Hsp68	physical	23749869
EF1B_DROME	Ef1beta	physical	23749869
RL19_DROME	RpL19	physical	23749869
OTE_DROME	Ote	physical	23749869
TAF4_DROME	Taf4	physical	23749869
SLE_DROME	sle	physical	23749869
MIC60_DROME	CG6455	physical	23749869
LVA_DROME	lva	physical	23749869
EF1A2_DROME	Ef1alpha100E	physical	23749869
EF1A1_DROME	Ef1alpha48D	physical	23749869
IF2A_DROME	eIF-2alpha	physical	23749869
CADF_DROME	tsr	physical	23749869
ISWI_DROME	Iswi	physical	23749869
CATL_DROME	Cp1	physical	23749869
RS2_DROME	RpS2	physical	23749869
RS10B_DROME	RpS10b	physical	23749869
NLP_DROME	Nlp	physical	23749869
VDAC_DROME	porin	physical	23749869
L2CC_DROME	l(2)37Cc	physical	23749869
ATPB_DROME	ATPsyn-beta	physical	23749869
KPYK_DROME	PyK	physical	23749869
RS28_DROME	RpS28b	physical	23749869
PEP_DROME	Pep	physical	23749869
ATNA_DROME	Atpalpha	physical	23749869
NFKB1_DROME	Rel	physical	25242320

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of IKKB_DROME

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos."; Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.; J. Proteome Res. 7:1675-1682(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-202 AND THR-225, ANDMASS SPECTROMETRY.	18327897 [Abstract]