| UniProt ID | NCD_DROME | |
|---|---|---|
| UniProt AC | P20480 | |
| Protein Name | Protein claret segregational | |
| Gene Name | ncd | |
| Organism | Drosophila melanogaster (Fruit fly). | |
| Sequence Length | 700 | |
| Subcellular Localization | Cytoplasm, cytoskeleton . | |
| Protein Description | NCD is required for normal chromosomal segregation in meiosis, in females, and in early mitotic divisions of the embryo. The NCD motor activity is directed toward the microtubule's minus end.. | |
| Protein Sequence | MESRLPKPSGLKKPQMPIKTVLPTDRIRAGLGGGAAGAGAFNVNANQTYCGNLLPPLSRDLNNLPQVLERRGGGARAASPEPMKLGHRAKLRRSRSACDINELRGNKRTAAAPSLPSIPSKVSRLGGALTVSSQRLVRPAAPSSITATAVKRPPVTRPAPRAAGGAAAKKPAGTGAAASSGAAAAAPKRIAPYDFKARFHDLLEKHKVLKTKYEKQTEDMGELESMPQQLEETQNKLIETESSLKNTQSDNECLQRQVKQHTAKIETITSTLGRTKEELSELQAIHEKVKTEHAALSTEVVHLRQRTEELLRCNEQQAAELETCKEQLFQSNMERKELHNTVMDLRGNIRVFCRIRPPLESEENRMCCTWTYHDESTVELQSIDAQAKSKMGQQIFSFDQVFHPLSSQSDIFEMVSPLIQSALDGYNICIFAYGQTGSGKTYTMDGVPESVGVIPRTVDLLFDSIRGYRNLGWEYEIKATFLEIYNEVLYDLLSNEQKDMEIRMAKNNKNDIYVSNITEETVLDPNHLRHLMHTAKMNRATASTAGNERSSRSHAVTKLELIGRHAEKQEISVGSINLVDLAGSESPKTSTRMTETKNINRSLSELTNVILALLQKQDHIPYRNSKLTHLLMPSLGGNSKTLMFINVSPFQDCFQESVKSLRFAASVNSCKMTKAKRNRYLNNSVANSSTQSNNSGSFDK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 79 | Phosphorylation | GGGARAASPEPMKLG CCCCCCCCCCCCCCC | 28.89 | 19429919 | |
| 94 | Phosphorylation | HRAKLRRSRSACDIN HHHHHHHHHCCCCHH | 24.93 | 19429919 | |
| 96 | Phosphorylation | AKLRRSRSACDINEL HHHHHHHCCCCHHHH | 34.20 | 21082442 | |
| 114 | Phosphorylation | KRTAAAPSLPSIPSK CCCCCCCCCCCCCHH | 48.46 | 21082442 | |
| 130 | Phosphorylation | SRLGGALTVSSQRLV HHHCCCEEECCCCCC | 20.15 | 29892262 | |
| 132 | Phosphorylation | LGGALTVSSQRLVRP HCCCEEECCCCCCCC | 18.60 | 29892262 | |
| 205 | Acetylation | RFHDLLEKHKVLKTK HHHHHHHHHCHHHHH | 49.01 | 21791702 | |
| 211 | Phosphorylation | EKHKVLKTKYEKQTE HHHCHHHHHHHHHCC | 34.40 | 22817900 | |
| 558 | Acetylation | SRSHAVTKLELIGRH HHHHHCHHHHHCCCH | 33.11 | 21791702 | |
| 695 | Phosphorylation | SSTQSNNSGSFDK-- CCCCCCCCCCCCC-- | 39.81 | 19429919 | |
| 697 | Phosphorylation | TQSNNSGSFDK---- CCCCCCCCCCC---- | 30.05 | 19429919 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of NCD_DROME !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of NCD_DROME !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of NCD_DROME !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| TBG2_DROME | gammaTub37C | genetic | 9701548 | |
| DYHC_DROME | Dhc64C | genetic | 16247025 | |
| TBA4_DROME | alphaTub67C | genetic | 9044053 | |
| SUB_DROME | sub | genetic | 11973304 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
| Phosphorylation | |
| Reference | PubMed |
| "Phosphoproteome analysis of Drosophila melanogaster embryos."; Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.; J. Proteome Res. 7:1675-1682(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-94 AND SER-96, AND MASSSPECTROMETRY. | |
