dbPTM

SUB_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SUB_DROME
UniProt AC	Q9V877
Protein Name	Kinesin-like protein subito
Gene Name	sub
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	628
Subcellular Localization	Cytoplasm . Cytoplasm, cytoskeleton . Microtubule-associated.
Protein Description	Required during female meiosis for bipolar spindle formation in the absence of the centrosomes and chromosome homolog segregation. Also has roles in male meiosis and mitotic divisions of the early embryo..
Protein Sequence	MDSKEVSEVPRREVRSFLMARDPSIDRRFRPRPNKKMRLFDNIQESEEESFSEYSDTESEYKYQSSEATEGASCATSAADSSNVETGPQVFLRLRPVKDASKAYIVSEEANVLITSCKVDSTSNNVNRMEKHFGFTSIFDSTVGQRDIYDTCVGPKIMEEECVTIMTYGTSGSGKTYTLLGDDVRAGIIPRALENIFTIYQDTVFRSPKLKLINGSIVFLQDDASLKELQIRKKLLDLCPDISAHHQRLKQVIDGDHMFETKASTDVSVLVWVSFVEIYNELVYDLLAIPPKQDKLGEVPRKNLKIVGNKGHVFIKGLTSVFVTSSEEALRLLRLGQQRSTYASTSVNANSSRSHCVFTVDILKYNRSGITTQSSYKFCDLAGSERVNNTGTSGLRLKEAKNINTSLMVLGRCLDAASTVQKKKNADIIPYRDSKLTMLLQAALLGKEKLAMIVTVTPLDKYYEENLNVLNFASIAKNIIFKEPVIKQHRVSYCGFMEFSKMSTCEGGDYTKELEDENVRLQLEIEQLKYDHVLQMQLLEEKLRRELTATYQEIIQNNKKQYEDECEKKLLIAQRESEFMLSSQRRRYEEQIEDLKDEIEELKNPASDTDISDDPNESKSPIEILDDD

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
24	Phosphorylation	FLMARDPSIDRRFRP HHHHCCCCCCCCCCC	41.22	22817900
588	Phosphorylation	LSSQRRRYEEQIEDL HHHHHHHHHHHHHHH	23.23	22817900
607	Phosphorylation	EELKNPASDTDISDD HHHHCCCCCCCCCCC	42.15	19429919
609	Phosphorylation	LKNPASDTDISDDPN HHCCCCCCCCCCCCC	32.51	19429919
612	Phosphorylation	PASDTDISDDPNESK CCCCCCCCCCCCCCC	38.48	19429919
620	Phosphorylation	DDPNESKSPIEILDD CCCCCCCCCCCCCCC	40.15	19429919

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SUB_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SUB_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SUB_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TRM1_DROME	CG6388	physical	22036573
NOD_DROME	nod	genetic	11973304
POLO_DROME	polo	genetic	17077127
NCD_DROME	ncd	genetic	11973304
NCD_DROME	ncd	genetic	17077127
RAN_DROME	Ran	genetic	22100918

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SUB_DROME

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos."; Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.; J. Proteome Res. 7:1675-1682(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-607; THR-609 ANDSER-612, AND MASS SPECTROMETRY.	18327897 [Abstract]