dbPTM

TRM1_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TRM1_DROME
UniProt AC	Q9VK89
Protein Name	Probable tRNA (guanine(26)-N(2))-dimethyltransferase
Gene Name	CG6388
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	578
Subcellular Localization
Protein Description	Dimethylates a single guanine residue at position 26 of most tRNAs using S-adenosyl-L-methionine as donor of the methyl groups..
Protein Sequence	MEVDEEKPQIIAENPNENVIRERNAEIVSGGNVFYNPVQEFNRDLSIAALNVYRQRLTKERSEKALKKQRKKVKEQEDEKTTPVPEDPPVYEAGTRYEDGLRILEALAATGLRSIRYAQEIAGVRQIVANDLSRQAVASINTNIRHNKVEELIEPSHSDAMTLMYLSTQPEKRFDAVDLDPYGCPNRFLDGAMQCLVDGGLLLVTATDMAVLAGNAPEACYVKYGSVPLRMKCCHEMALRILLHCIESHANRYGKYIEPLLSISADFYIRIFVRVYVGQAQCKLSMSKQSWIYQCTGCETFTLQPLGITKPNPTAGNPQQLKFGIPTGPAVNSQCEHCGHRHHLGGPIWSAPIHNPEFVQDLLTAVQETTLQSLGTQRRIVGVLSMVQEELQDVPLYYTPDKLCCVLKLEIVPMLKFRSAILHAGYRVSYSHASKNSLKTNAPPAVLWDILRSWSKRHPVNPERMIPGSPLAAILSKECTAVYEFDELHPEANPKSRKSALSRFQENPTPHWGPGTRATIMIGDNKLPKSYRNQNKKQRHKASEQQAEDDQQDTPQAVDEYDGDVEHLPKQPKLEATA

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
469	Phosphorylation	PERMIPGSPLAAILS HHHCCCCCHHHHHHC	16.04	21082442
543	Phosphorylation	KKQRHKASEQQAEDD HHHHHHHHHHHHHHH	40.52	19429919

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of TRM1_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of TRM1_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TRM1_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of TRM1_DROME !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TRM1_DROME

Related Literatures of Post-Translational Modification