EF1A2_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EF1A2_DROME
• UniProt AC: P05303
• Protein Name: Elongation factor 1-alpha 2
• Gene Name: Ef1alpha100E
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 462
• Subcellular Localization: Cytoplasm.
• Protein Description: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis..
• Protein Sequence: MGKEKIHINIVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAQEMGKGSFKYAWVLDKLKAERERGITIDIALWKFETSKYYVTIIDAPGHRDFIKNMITGTSQADCAVLIVAAGTGEFEAGISKNGQTREHALLAFTLGVKQLIVGVNKMDSTEPPYSEARYEEIKKEVSSYIKKIGYNPASVAFVPISGWHGDNMLEPSEKMPWFKGWSVERKEGKAEGKCLIDALDAILPPQRPTDKPLRLPLQDVYKIGGIGTVPVGRVETGLLKPGMVVNFAPVNLVTEVKSVEMHHEALTEAMPGDNVGFNVKNVSVKELRRGYVAGDSKNNPPRGAADFTAQVIVLNHPGQIANGYTPVLDCHTAHIACKFSEIKEKCDRRTGKTTETEPKAIKSGDAAIIVLVPSKPLCVESFQEFPPLGRFAVRDMRQTVAVGVIKSVNFKETTSGKVTKAAEKAQKKK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
23	Phosphorylation	VDSGKSTTTGHLIYK CCCCCCCCCCEEEEE	37.56	27794539
29	Phosphorylation	TTTGHLIYKCGGIDK CCCCEEEEECCCCCH	13.44	19429919
30	Acetylation	TTGHLIYKCGGIDKR CCCEEEEECCCCCHH	21.29	21791702
41	Acetylation	IDKRTIEKFEKEAQE CCHHHHHHHHHHHHH	55.78	21791702
44	Acetylation	RTIEKFEKEAQEMGK HHHHHHHHHHHHCCC	62.57	21791702
55	Acetylation	EMGKGSFKYAWVLDK HCCCCCHHHHHHHHH	35.44	21791702
172	Acetylation	ARYEEIKKEVSSYIK HHHHHHHHHHHHHHH	69.84	21791702
255	Acetylation	LPLQDVYKIGGIGTV CCHHHEEEECCCEEE	34.42	21791702
291	Phosphorylation	NLVTEVKSVEMHHEA CCEEEEEEEEHHHHH	28.61	30478224
301	5-glutamyl glycerylphosphorylethanolamine	MHHEALTEAMPGDNV HHHHHHHHHCCCCCC	43.77	-
301	Formation of an isopeptide bond	MHHEALTEAMPGDNV HHHHHHHHHCCCCCC	43.77	-
374	5-glutamyl glycerylphosphorylethanolamine	HIACKFSEIKEKCDR HHEECHHHHHHHHHC	62.30	-
374	Formation of an isopeptide bond	HIACKFSEIKEKCDR HHEECHHHHHHHHHC	62.30	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of EF1A2_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EF1A2_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EF1A2_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
EF1D_DROME	eEF1delta	physical	22036573

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.