dbPTM

EF1D_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	EF1D_DROME
UniProt AC	Q9VL18
Protein Name	Probable elongation factor 1-delta
Gene Name	eEF1delta
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	256
Subcellular Localization
Protein Description	EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP..
Protein Sequence	MKVEALDKFWADKSRYDLAEKRFYEGPQKVTDRSHYSPLVSEIAKAREHIQNSLEKIDGVTLDDGLNSELAKRLAQLEGEHKELKTQVSLLNELLTATVKRLETQLKLTNGVSKEPEVEAKKPEANDDDDDVDLFGSDSEEEDGEAARIREERLAAYAAKKAKKVQIIAKSNIILDVKPWDDETDLKVMETEIRKITQDGLLWGASKFVPVAFGIQKLSISCVVEDDKVSIDWLTEEIEKLEDFVQSVDIAAFNKI

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
34	Phosphorylation	PQKVTDRSHYSPLVS CCCCCCCCCCHHHHH	29.59	19429919
36	Phosphorylation	KVTDRSHYSPLVSEI CCCCCCCCHHHHHHH	17.15	19429919
37	Phosphorylation	VTDRSHYSPLVSEIA CCCCCCCHHHHHHHH	13.31	19429919
41	Phosphorylation	SHYSPLVSEIAKARE CCCHHHHHHHHHHHH	30.85	19429919
53	Phosphorylation	AREHIQNSLEKIDGV HHHHHHHHHHHCCCC	22.87	21082442
56	Ubiquitination	HIQNSLEKIDGVTLD HHHHHHHHCCCCCCC	51.93	31113955
61	Phosphorylation	LEKIDGVTLDDGLNS HHHCCCCCCCCCCCH	29.96	22668510
86	Phosphorylation	GEHKELKTQVSLLNE HHHHHHHHHHHHHHH	46.99	28490779
89	Phosphorylation	KELKTQVSLLNELLT HHHHHHHHHHHHHHH	19.81	19429919
137	Phosphorylation	DDVDLFGSDSEEEDG CCCCCCCCCCCCCCC	30.54	21082442
139	Phosphorylation	VDLFGSDSEEEDGEA CCCCCCCCCCCCCHH	48.91	21082442

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of EF1D_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of EF1D_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of EF1D_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
R10AB_DROME	RpL10Ab	physical	14605208
NACA_DROME	Nacalpha	physical	22036573
TERA_DROME	TER94	physical	22036573
YC17_DROME	CG16817	physical	22036573
SH3BG_DROME	Sh3beta	physical	22036573
U430_DROME	CG31712	physical	22036573

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of EF1D_DROME

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos."; Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.; J. Proteome Res. 7:1675-1682(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-37; SER-53; SER-137 ANDSER-139, AND MASS SPECTROMETRY.	18327897 [Abstract]
"An integrated chemical, mass spectrometric and computational strategyfor (quantitative) phosphoproteomics: application to Drosophilamelanogaster Kc167 cells."; Bodenmiller B., Mueller L.N., Pedrioli P.G.A., Pflieger D.,Juenger M.A., Eng J.K., Aebersold R., Tao W.A.; Mol. Biosyst. 3:275-286(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-89, AND MASSSPECTROMETRY.	17372656 [Abstract]