MA205_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MA205_DROME
• UniProt AC: P23226
• Protein Name: 205 kDa microtubule-associated protein
• Gene Name: Map205
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 1185
• Subcellular Localization: Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle. Associated with cytoplasmic microtubules and with the mitotic spindle.
• Protein Description: May play an important role in the regulation of microtubule assembly and interaction..
• Protein Sequence: MEHHEDNAQLDNYLQNRLAESLQICGGAGEHNPHLADATGGNGCAPGIAPSKSDEVDGEEDEEWKYIHEVRQSEKLQQEKLPLTKETGNGFGPGRDSDNQVHGNGAAAVFNLYEEDVEVIKNDGDFSTNSNTTTSTDEVVARQAQEPNQLPEQLQQQQQIESQGVHEDPRQEDEDEHSSVATTYGTSSLSENNSSPLDQEEVVMVAQTVGQEQLVDFDNKENSYFVKNLEENHSQLNPNAVAFVPGVGSQSSSPLPAAEDPLPGVQPRPFLPGGTLDDLVAESPRKEFARINMDGIAVPDEREFDIEADMRPHELEQESDTFGAGHLEMQLLNGIGTADQAALRDVLDHGPETSVDMELPLDQVPNDADIMKQSIYAEHNSSIEDILNSVQPLPIQTCDDKELIHVEEKEHVSKSPSTEELQFQSDFPNNQESHTLFNNTEQDPMQASFYLEHTSQKAQEGCQEQMQLPAECSDIFADQSLLLDTSAPQLSSEADSPVAKLELESQQAGIVDITPSPLSSTAEKHLVEDTKELVEEYTLDPESHFFGVVSSQAPLQLFGKHTLPSIIHSCKHRVASEQNDEENAVFESVSGYETQNFDEISSPPEGINPFAQPFTPAHLVIEQANTMMEDVGGMPIPASEDFAICDKVASKSSNEVEDHRSEQQAFVKEELLHPVGDVVAQVENLGTEKNFVVEEERLPISVSDEIPLSSASKEKLLPDTTDEQLLTSALEEKLRSVAPEESVSTAADGQSISQFDEYVIASNKPLEDILEPEKDVEVAKSLSEKTSVATVAGGAVVGATKTHSATKAGSTAASAKSKTETLVMKKTTASSTSVYGANKSAAPRPSTARLGIKSTSIATKTSTTSSLTGNPRKSLSSNVGSTVKPPTKLSGTRPATAPVSKVTLGAKTITNKPTASGTASDNVTRTTLRPLVSTNARRPATSGTGSVASSTARRPVTNAKGSAPGSAASTKVRPAATMTAPVKPKVLSPRSTISSTTTVRKVPSTSTPSFSTRSPNKQQSNGLGKNTSSTTTSTATATITKSFTARSAPKFTHSASLTYNNGSTSRRLLVPGSSSTTTTSSLRKSSPLKAAPGKAASKPLTPQSKDGTAKSSPAVLKARNSTLMGGEGVAPSNECVPTPNGQINAEEVVKLKGKGLAEEVKIIEEQKLHEQDVPAHNAEVPLLDF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
13	Phosphorylation	DNAQLDNYLQNRLAE HHHHHHHHHHHHHHH	14.88	19429919
73	Phosphorylation	YIHEVRQSEKLQQEK HHHHHHHHHHHHHHC	26.57	21082442
127	Phosphorylation	IKNDGDFSTNSNTTT ECCCCCCCCCCCCCC	31.27	29892262
128	Phosphorylation	KNDGDFSTNSNTTTS CCCCCCCCCCCCCCC	42.53	29892262
130	Phosphorylation	DGDFSTNSNTTTSTD CCCCCCCCCCCCCHH	35.32	29892262
132	Phosphorylation	DFSTNSNTTTSTDEV CCCCCCCCCCCHHHH	31.13	29892262
249	Phosphorylation	AFVPGVGSQSSSPLP EECCCCCCCCCCCCC	25.20	19429919
251	Phosphorylation	VPGVGSQSSSPLPAA CCCCCCCCCCCCCCC	34.18	19429919
252	Phosphorylation	PGVGSQSSSPLPAAE CCCCCCCCCCCCCCC	28.47	19429919
253	Phosphorylation	GVGSQSSSPLPAAED CCCCCCCCCCCCCCC	35.39	19429919
283	Phosphorylation	LDDLVAESPRKEFAR HHHHHHHCCHHHHCE	21.92	19429919
353	Phosphorylation	VLDHGPETSVDMELP HHHHCCCCCCCEECC	36.86	19429919
354	Phosphorylation	LDHGPETSVDMELPL HHHCCCCCCCEECCH	17.92	19429919
374	Phosphorylation	DADIMKQSIYAEHNS CHHHHHHHHHHHCCC	16.43	21082442
376	Phosphorylation	DIMKQSIYAEHNSSI HHHHHHHHHHCCCCH	15.93	21082442
381	Phosphorylation	SIYAEHNSSIEDILN HHHHHCCCCHHHHHH	34.30	27794539
382	Phosphorylation	IYAEHNSSIEDILNS HHHHCCCCHHHHHHH	35.00	22817900
413	Phosphorylation	VEEKEHVSKSPSTEE EEEHHHHCCCCCHHH	29.35	22668510
415	Phosphorylation	EKEHVSKSPSTEELQ EHHHHCCCCCHHHCC	19.31	22668510
417	Phosphorylation	EHVSKSPSTEELQFQ HHHCCCCCHHHCCCC	56.39	22668510
418	Phosphorylation	HVSKSPSTEELQFQS HHCCCCCHHHCCCCC	36.54	22668510
425	Phosphorylation	TEELQFQSDFPNNQE HHHCCCCCCCCCCHH	42.37	22668510
448	Phosphorylation	EQDPMQASFYLEHTS CCCHHHHHHHHHHHH	9.49	22817900
450	Phosphorylation	DPMQASFYLEHTSQK CHHHHHHHHHHHHHH	14.53	18327897
514	Phosphorylation	QAGIVDITPSPLSST CCCCCCCCCCCCCCH	17.16	19429919
516	Phosphorylation	GIVDITPSPLSSTAE CCCCCCCCCCCCHHH	29.80	19429919
519	Phosphorylation	DITPSPLSSTAEKHL CCCCCCCCCHHHHHH	29.09	19429919
520	Phosphorylation	ITPSPLSSTAEKHLV CCCCCCCCHHHHHHH	39.04	19429919
521	Phosphorylation	TPSPLSSTAEKHLVE CCCCCCCHHHHHHHH	35.14	19429919
633 (in isoform 2)	Phosphorylation	-	20.67	29892262
634 (in isoform 2)	Phosphorylation	-	1.93	27794539
636 (in isoform 2)	Phosphorylation	-	3.10	27794539
650	Phosphorylation	AICDKVASKSSNEVE EECHHHCCCCCCCHH	35.74	19429919
652	Phosphorylation	CDKVASKSSNEVEDH CHHHCCCCCCCHHCH	35.58	19429919
653	Phosphorylation	DKVASKSSNEVEDHR HHHCCCCCCCHHCHH	40.52	19429919
687	Phosphorylation	AQVENLGTEKNFVVE HHHHCCCCCCCEEEE	47.13	19429919
701	Phosphorylation	EEERLPISVSDEIPL EEECCCCCCCCCCCC	17.39	19429919
703	Phosphorylation	ERLPISVSDEIPLSS ECCCCCCCCCCCCCC	23.80	19429919
709	Phosphorylation	VSDEIPLSSASKEKL CCCCCCCCCCCCCCC	20.64	19429919
710	Phosphorylation	SDEIPLSSASKEKLL CCCCCCCCCCCCCCC	44.22	19429919
712	Phosphorylation	EIPLSSASKEKLLPD CCCCCCCCCCCCCCC	43.21	19429919
720	Phosphorylation	KEKLLPDTTDEQLLT CCCCCCCCCCHHHHH	33.92	21082442
721	Phosphorylation	EKLLPDTTDEQLLTS CCCCCCCCCHHHHHH	44.94	22817900
727	Phosphorylation	TTDEQLLTSALEEKL CCCHHHHHHHHHHHH	22.13	19429919
728	Phosphorylation	TDEQLLTSALEEKLR CCHHHHHHHHHHHHH	30.72	19429919
786	Phosphorylation	AKSLSEKTSVATVAG HHHHCCCCCEEEEEC	25.12	21082442
787	Phosphorylation	KSLSEKTSVATVAGG HHHCCCCCEEEEECC	22.33	21082442
821	Phosphorylation	SAKSKTETLVMKKTT HCCCCCCEEEEEEEC	29.86	21082442
828	Phosphorylation	TLVMKKTTASSTSVY EEEEEEECCCCCCCC	33.16	21082442
833	Phosphorylation	KTTASSTSVYGANKS EECCCCCCCCCCCCC	18.45	21082442
835	Phosphorylation	TASSTSVYGANKSAA CCCCCCCCCCCCCCC	15.41	18281928
846	Phosphorylation	KSAAPRPSTARLGIK CCCCCCCCCCCCCCE	35.66	21082442
847	Phosphorylation	SAAPRPSTARLGIKS CCCCCCCCCCCCCEE	20.62	21082442
854	Phosphorylation	TARLGIKSTSIATKT CCCCCCEEEEEEEEE	26.01	25749252
855	Phosphorylation	ARLGIKSTSIATKTS CCCCCEEEEEEEEEC	21.10	27626673
856	Phosphorylation	RLGIKSTSIATKTST CCCCEEEEEEEEECC	19.81	22817900
866	Phosphorylation	TKTSTTSSLTGNPRK EEECCCCCCCCCCCC	28.05	18511481
874	Phosphorylation	LTGNPRKSLSSNVGS CCCCCCCCCCCCCCC	34.46	19429919
876	Phosphorylation	GNPRKSLSSNVGSTV CCCCCCCCCCCCCCC	27.27	29892262
877	Phosphorylation	NPRKSLSSNVGSTVK CCCCCCCCCCCCCCC	40.61	18511481
892	Phosphorylation	PPTKLSGTRPATAPV CCCCCCCCCCCCCCC	30.06	22817900
896	Phosphorylation	LSGTRPATAPVSKVT CCCCCCCCCCCCEEE	33.89	19429919
926	Phosphorylation	ASDNVTRTTLRPLVS CCCCCCHHCCCCCCC	22.33	21082442
927	Phosphorylation	SDNVTRTTLRPLVST CCCCCHHCCCCCCCC	19.92	21082442
933	Phosphorylation	TTLRPLVSTNARRPA HCCCCCCCCCCCCCC	24.51	21082442
934	Phosphorylation	TLRPLVSTNARRPAT CCCCCCCCCCCCCCC	25.97	21082442
941	Phosphorylation	TNARRPATSGTGSVA CCCCCCCCCCCCCCC	30.30	21082442
942	Phosphorylation	NARRPATSGTGSVAS CCCCCCCCCCCCCCC	36.14	21082442
944	Phosphorylation	RRPATSGTGSVASST CCCCCCCCCCCCCCC	26.50	21082442
946	Phosphorylation	PATSGTGSVASSTAR CCCCCCCCCCCCCCC	17.85	21082442
949	Phosphorylation	SGTGSVASSTARRPV CCCCCCCCCCCCCCC	26.51	21082442
950	Phosphorylation	GTGSVASSTARRPVT CCCCCCCCCCCCCCC	19.15	18511481
951	Phosphorylation	TGSVASSTARRPVTN CCCCCCCCCCCCCCC	22.99	21082442
962	Phosphorylation	PVTNAKGSAPGSAAS CCCCCCCCCCCCCCC	30.50	22817900
988	Phosphorylation	PVKPKVLSPRSTISS CCCCCCCCCCCCCCC	22.66	22668510
991	Phosphorylation	PKVLSPRSTISSTTT CCCCCCCCCCCCCCE	33.21	21082442
992	Phosphorylation	KVLSPRSTISSTTTV CCCCCCCCCCCCCEE	26.59	21082442
1004	Phosphorylation	TTVRKVPSTSTPSFS CEEEECCCCCCCCCC	37.67	21082442
1005	Phosphorylation	TVRKVPSTSTPSFST EEEECCCCCCCCCCC	30.46	21082442
1006	Phosphorylation	VRKVPSTSTPSFSTR EEECCCCCCCCCCCC	42.53	21082442
1007	Phosphorylation	RKVPSTSTPSFSTRS EECCCCCCCCCCCCC	24.04	19429919
1009	Phosphorylation	VPSTSTPSFSTRSPN CCCCCCCCCCCCCCC	31.73	19429919
1011	Phosphorylation	STSTPSFSTRSPNKQ CCCCCCCCCCCCCCC	27.52	19429919
1012	Phosphorylation	TSTPSFSTRSPNKQQ CCCCCCCCCCCCCCC	32.91	19429919
1014	Phosphorylation	TPSFSTRSPNKQQSN CCCCCCCCCCCCCCC	32.67	19429919
1031	O-linked_Glycosylation	GKNTSSTTTSTATAT CCCCCCCCCCCEEEE	22.24	20146544
1036	Phosphorylation	STTTSTATATITKSF CCCCCCEEEEEEECE	25.15	21082442
1038	Phosphorylation	TTSTATATITKSFTA CCCCEEEEEEECEEC	25.48	21082442
1052	Phosphorylation	ARSAPKFTHSASLTY CCCCCCEEEEEEEEE	22.50	19429919
1054	Phosphorylation	SAPKFTHSASLTYNN CCCCEEEEEEEEECC	19.25	19429919
1056	Phosphorylation	PKFTHSASLTYNNGS CCEEEEEEEEECCCC	25.02	19429919
1058	Phosphorylation	FTHSASLTYNNGSTS EEEEEEEEECCCCCC	23.00	19429919
1059	Phosphorylation	THSASLTYNNGSTSR EEEEEEEECCCCCCC	16.36	19429919
1063	Phosphorylation	SLTYNNGSTSRRLLV EEEECCCCCCCEEEE	25.90	19429919
1064	Phosphorylation	LTYNNGSTSRRLLVP EEECCCCCCCEEEEC	27.87	19429919
1065	Phosphorylation	TYNNGSTSRRLLVPG EECCCCCCCEEEECC	19.66	19429919
1074	Phosphorylation	RLLVPGSSSTTTTSS EEEECCCCCCCCCCC	37.30	21082442
1075	Phosphorylation	LLVPGSSSTTTTSSL EEECCCCCCCCCCCH	31.32	19060867
1076	Phosphorylation	LVPGSSSTTTTSSLR EECCCCCCCCCCCHH	30.06	21082442
1078	Phosphorylation	PGSSSTTTTSSLRKS CCCCCCCCCCCHHCC	25.43	21082442
1081	Phosphorylation	SSTTTTSSLRKSSPL CCCCCCCCHHCCCCC	30.05	22817900
1085	Phosphorylation	TTSSLRKSSPLKAAP CCCCHHCCCCCCCCC	30.65	22817900
1086	Phosphorylation	TSSLRKSSPLKAAPG CCCHHCCCCCCCCCC	36.97	22817900
1097	Phosphorylation	AAPGKAASKPLTPQS CCCCCCCCCCCCCCC	39.40	27626673
1098	Acetylation	APGKAASKPLTPQSK CCCCCCCCCCCCCCC	39.04	21791702
1101	Phosphorylation	KAASKPLTPQSKDGT CCCCCCCCCCCCCCC	28.01	22817900
1104	Phosphorylation	SKPLTPQSKDGTAKS CCCCCCCCCCCCCCC	33.64	22817900
1112	Phosphorylation	KDGTAKSSPAVLKAR CCCCCCCCHHHHHHC	19.03	30478224
1121	Phosphorylation	AVLKARNSTLMGGEG HHHHHCCCCCCCCCC	19.84	22817900
1122	Phosphorylation	VLKARNSTLMGGEGV HHHHCCCCCCCCCCC	25.06	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
283	S	Phosphorylation	Kinase	CDK1	P23572	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MA205_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MA205_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PGPLE_DROME	PGRP-LE	physical	22036573
POLO_DROME	polo	physical	22036573
ATX2_DROME	Atx2	physical	22036573

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-448; TYR-450; SER-709;SER-710; SER-712; SER-874 AND SER-1086, AND MASS SPECTROMETRY.
PubMed: 18327897

"An integrated chemical, mass spectrometric and computational strategyfor (quantitative) phosphoproteomics: application to Drosophilamelanogaster Kc167 cells.";
Bodenmiller B., Mueller L.N., Pedrioli P.G.A., Pflieger D.,Juenger M.A., Eng J.K., Aebersold R., Tao W.A.;
Mol. Biosyst. 3:275-286(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-354; THR-721; SER-728;SER-1075 AND SER-1121, AND MASS SPECTROMETRY.
PubMed: 17372656