TAF6_DROME - dbPTM
TAF6_DROME - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TAF6_DROME
UniProt AC P49847
Protein Name Transcription initiation factor TFIID subunit 6
Gene Name Taf6
Organism Drosophila melanogaster (Fruit fly).
Sequence Length 606
Subcellular Localization Nucleus.
Protein Description TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors..
Protein Sequence MSGKPSKPSSPSSSMLYGSSISAESMKVIAESIGVGSLSDDAAKELAEDVSIKLKRIVQDAAKFMNHAKRQKLSVRDIDMSLKVRNVEPQYGFVAKDFIPFRFASGGGRELHFTEDKEIDLGEITSTNSVKIPLDLTLRSHWFVVEGVQPTVPENPPPLSKDSQLLDSVNPVIKMDQGLNKDAAGKPTTGKIHKLKNVETIHVKQLATHELSVEQQLYYKEITEACVGSDEPRRGEALQSLGSDPGLHEMLPRMCTFIAEGVKVNVVQNNLALLIYLMRMVRALLDNPSLFLEKYLHELIPSVMTCIVSKQLCMRPELDNHWALRDFASRLMAQICKNFNTLTNNLQTRVTRIFSKALQNDKTHLSSLYGSIAGLSELGGEVIKVFIIPRLKFISERIEPHLLGTSISNTDKTAAGHIRAMLQKCCPPILRQMRSAPDTAEDYKNDFGFLGPSLCQAVVKVRNAPASSIVTLSSNTINTAPITSAAQTATTIGRVSMPTTQRQGSPGVSSLPQIRAIQANQPAQKFVIVTQNSPQQGQAKVVRRGSSPHSVVLSAASNAASASNSNSSSSGSLLAAAQRSSDNVCVIAGSEAPAVDGITVQSFRAS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
505PhosphorylationPTTQRQGSPGVSSLP
CCCCCCCCCCCCCCH		15.3325749252
533PhosphorylationFVIVTQNSPQQGQAK
EEEEECCCCCCCCCE		17.8028490779
546PhosphorylationAKVVRRGSSPHSVVL
CEEEECCCCCCHHHH		38.5919429919
547PhosphorylationKVVRRGSSPHSVVLS
EEEECCCCCCHHHHH		29.4719429919
550PhosphorylationRRGSSPHSVVLSAAS
ECCCCCCHHHHHHHC		19.8019429919
554PhosphorylationSPHSVVLSAASNAAS
CCCHHHHHHHCCCHH		15.3519429919
557PhosphorylationSVVLSAASNAASASN
HHHHHHHCCCHHCCC		27.0719429919
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TAF6_DROME !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TAF6_DROME !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TAF6_DROME !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
TAF1_DROMETaf1physical
16895980
TAF4_DROMETaf4physical
16895980
TAF5_DROMETaf5physical
16895980
TAF9_DROMEe(y)1physical
16895980
TBP_DROMETbpphysical
16895980
TAF9_DROMEe(y)1physical
20008933
TAF8_DROMETaf8physical
20008933
TAFAB_DROMETaf10bphysical
20008933
TAF10_DROMETaf10physical
20008933
TRF_DROMETrfphysical
20008933
TAF11_DROMETaf11physical
20008933
TBP_DROMETbpphysical
20008933
TAF2_DROMETaf2physical
20008933
TAF4_DROMETaf4physical
20008933
TAF1_DROMETaf1physical
20008933
TAF7_DROMETaf7physical
20008933
TAF12_DROMETaf12physical
20008933
TAF5_DROMETaf5physical
20008933
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TAF6_DROME

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-546; SER-547 ANDSER-550, AND MASS SPECTROMETRY.

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