TAF7_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TAF7_DROME
• UniProt AC: Q9VHY5
• Protein Name: Transcription initiation factor TFIID subunit 7
• Gene Name: Taf7
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 479
• Subcellular Localization: Nucleus.
• Protein Description: TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors..
• Protein Sequence: MPSLAVPHLTPISNEHLVSSKEVVFFWKNRIEMFEKKSDKVKQAEHKARDDGVELESQFIMRVPKELADTVHEAINAGTIKDRLTIQLDPDLRYGEVRIDDQILYTKLVDLPTVVESYKTIDNKSFYKSADICQILICKEEREDETEKESPNKNKKKDPNKVDKKYLFPHGITPPCKNVRKRRFRKTLKKKNVEAPEIEKEVKHLLRIDNEAVRVDYEIINEEDKPMDELEQSDIKPYNDADDDLQDESTMHASEKTIMEMSSQRHLQVESDDDEASNFPSHRAPNMGVAVHDIFGEEVSSTDDEDEPDRGNNTMQRRVMEESSRLSADDSRMSDFFGASGSNTGAGVVKMEQNVFSKSMFGHEASSPKLSAAGSSSNLAAPSGFYDSQMLAKREEFENMEFIDEPQPQYTQQQVQQKINQLTRQIRELKAQQVQKSTEIASIQNATLKQRMQETLDNLYTQVIERELELKDFENMLES

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
146	Phosphorylation	KEEREDETEKESPNK HHHCCCCCCCCCCCC	65.76	19429919
150	Phosphorylation	EDETEKESPNKNKKK CCCCCCCCCCCCCCC	44.86	19429919
233	Phosphorylation	PMDELEQSDIKPYND CHHHHHHCCCCCCCC	31.74	22817900
271	Phosphorylation	QRHLQVESDDDEASN HCCEEECCCCCHHHC	47.70	21082442
277	Phosphorylation	ESDDDEASNFPSHRA CCCCCHHHCCCCCCC	36.64	22817900
300	Phosphorylation	DIFGEEVSSTDDEDE HHCCCCCCCCCCCCC	30.69	22817900
301	Phosphorylation	IFGEEVSSTDDEDEP HCCCCCCCCCCCCCC	40.82	22817900
302	Phosphorylation	FGEEVSSTDDEDEPD CCCCCCCCCCCCCCC	39.71	22817900
327	Phosphorylation	MEESSRLSADDSRMS HHHHHCCCCCCCHHH	28.65	19429919
334	Phosphorylation	SADDSRMSDFFGASG CCCCCHHHHHCCCCC	30.10	29892262
366	Phosphorylation	SMFGHEASSPKLSAA HHCCCCCCCCCCCCC	44.16	19429919
367	Phosphorylation	MFGHEASSPKLSAAG HCCCCCCCCCCCCCC	32.85	19429919
371	Phosphorylation	EASSPKLSAAGSSSN CCCCCCCCCCCCCCC	23.38	22817900
423	Phosphorylation	QQKINQLTRQIRELK HHHHHHHHHHHHHHH	15.68	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TAF7_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TAF7_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TAF7_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CSKP_DROME	CASK	physical	14605208

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-233; SER-271; SER-277;SER-300; SER-301; THR-302; SER-367 AND SER-371, AND MASS SPECTROMETRY.
PubMed: 18327897