PRDX1_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PRDX1_DROME
• UniProt AC: Q9V3P0
• Protein Name: Peroxiredoxin 1
• Gene Name: Jafrac1
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 194
• Subcellular Localization: Cytoplasm .
• Protein Description: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2) (By similarity). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation (By similarity)..
• Protein Sequence: MPQLQKPAPAFAGTAVVNGVFKDIKLSDYKGKYLVLFFYPLDFTFVCPTEIIAFSESAAEFRKINCEVIGCSTDSQFTHLAWINTPRKQGGLGSMDIPLLADKSMKVARDYGVLDEETGIPFRGLFIIDDKQNLRQITVNDLPVGRSVEETLRLVQAFQYTDKYGEVCPANWKPGQKTMVADPTKSKEYFETTS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
27	Phosphorylation	VFKDIKLSDYKGKYL EEECEECHHCCCCEE	33.61	19429919
94	Phosphorylation	RKQGGLGSMDIPLLA CHHCCCCCCCHHHHC	20.51	19429919
193	Phosphorylation	SKEYFETTS------ CHHHHCCCC------	25.82	18327897
194	Phosphorylation	KEYFETTS------- HHHHCCCC-------	45.72	18327897

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PRDX1_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PRDX1_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PRDX1_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SRX_DROME	CG6762	physical	14605208

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-193 AND SER-194, ANDMASS SPECTROMETRY.
PubMed: 18327897