TBA3_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TBA3_DROME
• UniProt AC: P06605
• Protein Name: Tubulin alpha-3 chain
• Gene Name: alphaTub84D
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 450
• Subcellular Localization: Cytoplasm, cytoskeleton.
• Protein Description: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain..
• Protein Sequence: MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTVGGGDDSFNTFFSETGAGKHVPRAVFVDLEPTVVDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIVDLVLDRIRKLADQCTGLQGFLIFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFAVYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLIGQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLVTYAPVISAEKAYHEQLSVAEITNACFEPANQMVKVDPRHGKYMACCMLYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVGMDSGDGEGEGAEEY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
40	Acetylation	DGQMPSDKTVGGGDD CCCCCCCCCCCCCCC	49.82	-
48	Phosphorylation	TVGGGDDSFNTFFSE CCCCCCCCHHHCCCC	25.74	19429919
51	Phosphorylation	GGDDSFNTFFSETGA CCCCCHHHCCCCCCC	24.85	22817900
96	Ubiquitination	PEQLITGKEDAANNY HHHHCCCCHHHHHHC	43.71	31113955
112	Acetylation	RGHYTIGKEIVDLVL CCCCCCCHHHHHHHH	40.18	19608861
163	Acetylation	RLSVDYGKKSKLEFA HHCCCCCCCCCCEEE	47.87	19608861
277	Phosphorylation	VTYAPVISAEKAYHE EEECCCCCHHHHHHH	30.52	22817900
282	Phosphorylation	VISAEKAYHEQLSVA CCCHHHHHHHHCCHH	19.56	21082442
287	Phosphorylation	KAYHEQLSVAEITNA HHHHHHCCHHHHHHH	20.98	21082442
326	Acetylation	YRGDVVPKDVNAAIA CCCCCCCCCCCHHHH	63.80	19608861
394	Acetylation	AWARLDHKFDLMYAK HHHHCCCCCCHHHEE	39.99	19608861
401	Acetylation	KFDLMYAKRAFVHWY CCCHHHEEEHHHHHH	27.11	19608861
439	Phosphorylation	YEEVGMDSGDGEGEG HHHHCCCCCCCCCCC	29.86	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TBA3_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TBA3_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TBA3_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.