SLEL_DROME - dbPTM
SLEL_DROME - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SLEL_DROME
UniProt AC Q9VGZ8
Protein Name Slender lobes-like protein
Gene Name CG12592
Organism Drosophila melanogaster (Fruit fly).
Sequence Length 674
Subcellular Localization
Protein Description
Protein Sequence MRTIFNAKIGDAAYIQDELSSSLSSSVASKFKEFSKRKRISDSFSDLSEELERIGLRQMRKRIKLEKSFERTPKKKVQTKKHLPPVRKKDSVKRRRIIIASPSDEEHDGKVQTNDDSSENKTEKPKNQSNCSSNASKLSEAAQLLNVSEEKSSISETELERSRQVALNELNKSERFNKTETQLDISVMEVDSSDHDEEEKTEKVGAKNNRSLYEIVDSDDEEEQDQDQSDAAKPAESENHSEIKKSTSFMDQMSGAKGNKSVYEIMDSYETEDPKEAGKNEESDKDKPAENGKSDKDKQAETEMSDEDKPSEIKSPSTIKKSIISTADEEALLAELASSDLSHLEKMFNPLQKSRRQSLHVPSPELAAKNPKLRRRSERVEVGNDFCPSQSFVDMVAEKKRQKNKRKRLSKSLSGAPEDLEEMEIKHERKRLKSSHGASTDSMEEDNENETMTVAEEHHSDGEVSNGEVPIEEKPTTSSEKPSASELPEEGNSAPPALKKDVKRLQAARQAVSHAVNLLAPPKATEAEPRTLSRKLSPQPPVVDKKSAKQKKKGKKKQKPQEASPLKSSDEENHGHRIRTNAGYVTVVDEPPTKVPIIELIKTSSGMVRVEPCTPKQKYFRELPPTPKMHGFREEPGPSGMSRKRAKHAAPKVEHNSAKQAALRFKEQIFARRS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
101PhosphorylationRRRIIIASPSDEEHD
CCEEEEECCCCHHCC		17.9619429919
103PhosphorylationRIIIASPSDEEHDGK
EEEEECCCCHHCCCC		55.9819429919
122PhosphorylationDDSSENKTEKPKNQS
CCCCCCCCCCCCCCC		61.9018327897
139PhosphorylationSSNASKLSEAAQLLN
CCHHHHHHHHHHHCC		29.0029892262
148PhosphorylationAAQLLNVSEEKSSIS
HHHHCCCCHHHCCCC		38.6820450229
152PhosphorylationLNVSEEKSSISETEL
CCCCHHHCCCCHHHH		35.8619429919
153PhosphorylationNVSEEKSSISETELE
CCCHHHCCCCHHHHH		41.0019429919
155PhosphorylationSEEKSSISETELERS
CHHHCCCCHHHHHHH		40.1723607784
173PhosphorylationALNELNKSERFNKTE
HHHHCCHHHHCCCCC		32.6925749252
179PhosphorylationKSERFNKTETQLDIS
HHHHCCCCCCEEEEE		45.4218327897
186PhosphorylationTETQLDISVMEVDSS
CCCEEEEEEEECCCC		18.3223607784
192PhosphorylationISVMEVDSSDHDEEE
EEEEECCCCCCCHHH		42.7223607784
193PhosphorylationSVMEVDSSDHDEEEK
EEEECCCCCCCHHHH		34.2025749252
201PhosphorylationDHDEEEKTEKVGAKN
CCCHHHHHHCCCCCC		44.3023607784
211PhosphorylationVGAKNNRSLYEIVDS
CCCCCCCCCEEEECC		37.1118327897
246PhosphorylationNHSEIKKSTSFMDQM
CHHHHHHHHCHHHHH		25.0419429919
247PhosphorylationHSEIKKSTSFMDQMS
HHHHHHHHCHHHHHC		34.5619429919
248PhosphorylationSEIKKSTSFMDQMSG
HHHHHHHCHHHHHCC		26.1819429919
261PhosphorylationSGAKGNKSVYEIMDS
CCCCCCHHHHHHHHH		33.6518327897
263PhosphorylationAKGNKSVYEIMDSYE
CCCCHHHHHHHHHCC		13.5618327897
283PhosphorylationEAGKNEESDKDKPAE
HCCCCCCCCCCCCCC		43.7219429919
302PhosphorylationDKDKQAETEMSDEDK
HHHHHHHHHCCCCCC		39.7519429919
305PhosphorylationKQAETEMSDEDKPSE
HHHHHHCCCCCCCCC		31.4519429919
311PhosphorylationMSDEDKPSEIKSPST
CCCCCCCCCCCCHHH		58.6618327897
315PhosphorylationDKPSEIKSPSTIKKS
CCCCCCCCHHHHHHH		29.7322668510
317PhosphorylationPSEIKSPSTIKKSII
CCCCCCHHHHHHHHH		50.2722817900
322PhosphorylationSPSTIKKSIISTADE
CHHHHHHHHHHCCCH		21.8319429919
325PhosphorylationTIKKSIISTADEEAL
HHHHHHHHCCCHHHH		18.8419429919
326PhosphorylationIKKSIISTADEEALL
HHHHHHHCCCHHHHH		27.9319429919
358PhosphorylationLQKSRRQSLHVPSPE
HHHHHHHHCCCCCHH		20.7319429919
363PhosphorylationRQSLHVPSPELAAKN
HHHCCCCCHHHHHHC		29.8919429919
389PhosphorylationVGNDFCPSQSFVDMV
CCCCCCCCHHHHHHH		39.3718511481
391PhosphorylationNDFCPSQSFVDMVAE
CCCCCCHHHHHHHHH		31.4117372656
410PhosphorylationKNKRKRLSKSLSGAP
HHHHHHHHHHHCCCC		25.0021082442
412PhosphorylationKRKRLSKSLSGAPED
HHHHHHHHHCCCCHH		25.1319429919
414PhosphorylationKRLSKSLSGAPEDLE
HHHHHHHCCCCHHHH		39.7419429919
537PhosphorylationRTLSRKLSPQPPVVD
CCHHHCCCCCCCCCC		25.2319429919
564PhosphorylationKQKPQEASPLKSSDE
CCCCCCCCCCCCCCC		29.9719429919
568PhosphorylationQEASPLKSSDEENHG
CCCCCCCCCCCCCCC		51.1819429919
569PhosphorylationEASPLKSSDEENHGH
CCCCCCCCCCCCCCC		47.6719429919
614PhosphorylationMVRVEPCTPKQKYFR
CEEEEECCCCHHHHH		44.2127626673
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SLEL_DROME !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SLEL_DROME !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SLEL_DROME !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of SLEL_DROME !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SLEL_DROME

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"An integrated chemical, mass spectrometric and computational strategyfor (quantitative) phosphoproteomics: application to Drosophilamelanogaster Kc167 cells.";
Bodenmiller B., Mueller L.N., Pedrioli P.G.A., Pflieger D.,Juenger M.A., Eng J.K., Aebersold R., Tao W.A.;
Mol. Biosyst. 3:275-286(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-248; SER-358; SER-391AND SER-414, AND MASS SPECTROMETRY.

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