BCL9_DROME - dbPTM
BCL9_DROME - PTM Information in dbPTM
Basic Information of Protein
UniProt ID BCL9_DROME
UniProt AC Q961D9
Protein Name Protein BCL9 homolog
Gene Name lgs
Organism Drosophila melanogaster (Fruit fly).
Sequence Length 1469
Subcellular Localization Nucleus.
Protein Description Involved in signal transduction through the Wnt pathway..
Protein Sequence MLSTTMPRSPTQQQPQPNSDASSTSASGSNPGAAIGNGDSAASRSSPKTLNSEPFSTLSPDQIKLTPEEGTEKSGLSTSDKAATGGAPGSGNNLPEGQTMLRQNSTSTINSCLVASPQNSSEHSNSSNVSATVGLTQMVDCDEQSKKNKCSVKDEEAEISSNKAKGQAAGGGCETGSTSSLTVKEEPTDVLGSLVNMKKEERENHSPTMSPVGFGSIGNAQDNSATPVKIERISNDSTTEKKGSSLTMNNDEMSMEGCNQLNPDFINESLNNPAISSILVSGVGPIPGIGVGAGTGNLLTANANGISSGSSNCLDYMQQQNHIFVFSTQLANKGAESVLSGQFQTIIAYHCTQPATKSFLEDFFMKNPLKINKLQRHNSVGMPWIGMGQVGLTPPNPVAKITQQQPHTKTVGLLKPQFNQHENSKRSTVSAPSNSFVDQSDPMGNETELMCWEGGSSNTSRSGQNSRNHVDSISTSSESQAIKILEAAGVDLGQVTKGSDPGLTTENNIVSLQGVKVPDENLTPQQRQHREEQLAKIKKMNQFLFPENENSVGANVSSQITKIPGDLMMGMSGGGGGSIINPTMRQLHMPGNAKSELLSATSSGLSEDVMHPGDVISDMGAVIGCNNNQKTSVQCGSGVGVVTGTTAAGVNVNMHCSSSGAPNGNMMGSSTDMLASFGNTSCNVIGTAPDMSKEVLNQDSRTHSHQGGVAQMEWSKIQHQFFEERLKGGKPRQVTGTVVPQQQTPSGSGGNSLNNQVRPLQGPPPPYHSIQRSASVPIATQSPNPSSPNNLSLPSPRTTAAVMGLPTNSPSMDGTGSLSGSVPQANTSTVQAGTTTVLSANKNCFQADTPSPSNQNRSRNTGSSSVLTHNLSSNPSTPLSHLSPKEFESFGQSSAGDNMKSRRPSPQGQRSPVNSLIEANKDVRFAASSPGFNPHPHMQSNSNSALNAYKMGSTNIQMERQASAQGGSVQFSRRSDNIPLNPNSGNRPPPNKMTQNFDPISSLAQMSQQLTSCVSSMGSPAGTGGMTMMGGPGPSDINIEHGIISGLDGSGIDTINQNNCHSMNVVMNSMGPRMLNPKMCVAGGPNGPPGFNPNSPNGGLRENSIGSGCGSANSSNFQGVVPPGARMMGRMPVNFGSNFNPNIQVKASTPNTIQYMPVRAQNANNNNNNGANNVRMPPSLEFLQRYANPQMGAVGNGSPICPPSASDGTPGMPGLMAGPGAGGMLMNSSGEQHQNKITNNPGASNGINFFQNCNQMSIVDEEGGLPGHDGSMNIGQPSMIRGMRPHAMRPNVMGARMPPVNRQIQFAQSSDGIDCVGDPSSFFTNASCNSAGPHMFGSAQQANQPKTQHIKNIPSGMCQNQSGLAVAQGQIQLHGQGHAQGQSLIGPTNNNLMSTAGSVSATNGVSGINFVGPSSTDLKYAQQYHSFQQQLYATNTRSQQQQHMHQQHQSNMITMPPNLSPNPTFFVNK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
9PhosphorylationLSTTMPRSPTQQQPQ
CCCCCCCCCCCCCCC		26.8229892262
11PhosphorylationTTMPRSPTQQQPQPN
CCCCCCCCCCCCCCC		40.0129892262
59PhosphorylationSEPFSTLSPDQIKLT
CCCCCCCCHHHEEEC		26.9019429919
206PhosphorylationKEERENHSPTMSPVG
HHHHHCCCCCCCCCC		33.3819429919
208PhosphorylationERENHSPTMSPVGFG
HHHCCCCCCCCCCCC		33.0419429919
210PhosphorylationENHSPTMSPVGFGSI
HCCCCCCCCCCCCCC		20.9319429919
216PhosphorylationMSPVGFGSIGNAQDN
CCCCCCCCCCCCCCC		25.6819429919
224PhosphorylationIGNAQDNSATPVKIE
CCCCCCCCCCCEEEE		41.6429892262
226PhosphorylationNAQDNSATPVKIERI
CCCCCCCCCEEEEEC		28.5629892262
415AcetylationTKTVGLLKPQFNQHE
CCEEEEECCCCCCCC		41.6421791702
472PhosphorylationNSRNHVDSISTSSES
CCCCCCCCCCCCCHH		19.8321082442
704PhosphorylationNQDSRTHSHQGGVAQ
CCCCCCCCCCCCCCC		19.5222817900
773PhosphorylationPYHSIQRSASVPIAT
CCCCCCCCCCCCEEE		14.4419429919
775PhosphorylationHSIQRSASVPIATQS
CCCCCCCCCCEEECC		29.6719429919
780PhosphorylationSASVPIATQSPNPSS
CCCCCEEECCCCCCC		30.2419429919
782PhosphorylationSVPIATQSPNPSSPN
CCCEEECCCCCCCCC		23.4519429919
786PhosphorylationATQSPNPSSPNNLSL
EECCCCCCCCCCCCC		66.1319429919
787PhosphorylationTQSPNPSSPNNLSLP
ECCCCCCCCCCCCCC		32.6719429919
792PhosphorylationPSSPNNLSLPSPRTT
CCCCCCCCCCCCCCC		40.1219429919
795PhosphorylationPNNLSLPSPRTTAAV
CCCCCCCCCCCCCHH		32.1019429919
851PhosphorylationCFQADTPSPSNQNRS
EECCCCCCCCCCCCC		42.9529892262
873PhosphorylationVLTHNLSSNPSTPLS
HHHCCCCCCCCCCHH		56.7921082442
876PhosphorylationHNLSSNPSTPLSHLS
CCCCCCCCCCHHHCC		47.0819429919
877PhosphorylationNLSSNPSTPLSHLSP
CCCCCCCCCHHHCCH		29.5219429919
880PhosphorylationSNPSTPLSHLSPKEF
CCCCCCHHHCCHHHH		24.4819429919
883PhosphorylationSTPLSHLSPKEFESF
CCCHHHCCHHHHHHH		28.6219429919
893PhosphorylationEFESFGQSSAGDNMK
HHHHHCCCCCCCCCC		23.6430478224
894PhosphorylationFESFGQSSAGDNMKS
HHHHCCCCCCCCCCC		28.5130478224
905PhosphorylationNMKSRRPSPQGQRSP
CCCCCCCCCCCCCCC		28.2219429919
911PhosphorylationPSPQGQRSPVNSLIE
CCCCCCCCCHHHHHH		25.8819429919
963PhosphorylationIQMERQASAQGGSVQ
CEEEHHHHHCCCCEE		16.8821082442
975PhosphorylationSVQFSRRSDNIPLNP
CEEEEECCCCCCCCC		33.6221082442
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of BCL9_DROME !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of BCL9_DROME !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of BCL9_DROME !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ARM_DROMEarmphysical
11912189
PYGO_DROMEpygophysical
11912189
ARM_DROMEarmgenetic
15208637
ARM_DROMEarmphysical
11955446
PYGO_DROMEpygophysical
24183574
PYGO_DROMEpygophysical
11955446
PYGO_DROMEpygophysical
16005293
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of BCL9_DROME

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-9; THR-11; SER-206;THR-208; SER-210; SER-883; SER-905 AND SER-911, AND MASS SPECTROMETRY.

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