CATA_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CATA_DROME
• UniProt AC: P17336
• Protein Name: Catalase
• Gene Name: Cat
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 506
• Subcellular Localization: Peroxisome.
• Protein Description: Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide..
• Protein Sequence: MAGRDAASNQLIDYKNSQTVSPGAITTGNGAPIGIKDASQTVGPRGPILLQDVNFLDEMSHFDRERIPERVVHAKGAGAFGYFEVTHDITQYCAAKIFDKVKKRTPLAVRFSTVGGESGSADTARDPRGFAVKFYTEDGVWDLVGNNTPVFFIRDPILFPSFIHTQKRNPQTHLKDPDMFWDFLTLRPESAHQVCILFSDRGTPDGYCHMNGYGSHTFKLINAKGEPIYAKFHFKTDQGIKNLDVKTADQLASTDPDYSIRDLYNRIKTCKFPSWTMYIQVMTYEQAKKFKYNPFDVTKVWSQKEYPLIPVGKMVLDRNPKNYFAEVEQIAFSPAHLVPGVEPSPDKMLHGRLFSYSDTHRHRLGPNYLQIPVNCPYKVKIENFQRDGAMNVTDNQDGAPNYFPNSFNGPQECPRARALSSCCPVTGDVYRYSSGDTEDNFGQVTDFWVHVLDKCAKKRLVQNIAGHLSNASQFLQERAVKNFTQVHADFGRMLTEELNLAKSSKF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
17	Phosphorylation	QLIDYKNSQTVSPGA CCCCCCCCCEECCCC	24.07	19429919
19	Phosphorylation	IDYKNSQTVSPGAIT CCCCCCCEECCCCEE	23.83	19429919
21	Phosphorylation	YKNSQTVSPGAITTG CCCCCEECCCCEECC	22.47	19429919
60	Phosphorylation	VNFLDEMSHFDRERI CCHHHHCCCCCHHHC	20.96	22817900
82	Phosphorylation	KGAGAFGYFEVTHDI CCCCCCCEEEECCCH	7.07	27794539
219	Acetylation	GYGSHTFKLINAKGE CCCCCEEEEEECCCC	50.00	21791702
241	Acetylation	FKTDQGIKNLDVKTA ECCCCCCCCCCHHHH	59.28	21791702
246	Acetylation	GIKNLDVKTADQLAS CCCCCCHHHHHHHHC	37.35	21791702
291	Acetylation	YEQAKKFKYNPFDVT HHHHHCCCCCCCCCC	53.66	21791702
291	Ubiquitination	YEQAKKFKYNPFDVT HHHHHCCCCCCCCCC	53.66	31113955
355	Phosphorylation	MLHGRLFSYSDTHRH CCCCEECCCCCCCCC	28.46	19429919
357	Phosphorylation	HGRLFSYSDTHRHRL CCEECCCCCCCCCCC	34.53	22817900
420	Phosphorylation	CPRARALSSCCPVTG CCCHHHHHHCCCCCC	21.98	28490779
421	Phosphorylation	PRARALSSCCPVTGD CCHHHHHHCCCCCCC	22.16	28490779

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CATA_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CATA_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CATA_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
VIT2_DROME	Yp2	physical	22036573
MK14B_DROME	p38b	genetic	24656823

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.