VIT2_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: VIT2_DROME
• UniProt AC: P02844
• Protein Name: Vitellogenin-2
• Gene Name: Yp2
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 442
• Subcellular Localization: Secreted.
• Protein Description: Vitellogenin is the major yolk protein of eggs where it is used as a food source during embryogenesis..
• Protein Sequence: MNPLRTLCVMACLLAVAMGNPQSGNRSGRRSNSLDNVEQPSNWVNPREVEELPNLKEVTLKKLQEMSLEEGATLLDKLYHLSQFNHVFKPDYTPEPSQIRGYIVGERGQKIEFNLNTLVEKVKRQQKFGDDEVTIFIQGLPETNTQVQKATRKLVQAYQQRYNLQPYETTDYSNEEQSQRSSSEEQQTQRRKQNGEQDDTKTGDLIVIQLGNAIEDFEQYATLNIERLGEIIGNRLVELTNTVNVPQEIIHLIGSGPAAHVAGVAGRQFTRQTGHKLRRITALDPTKIYGKPEERLTGLARGDADFVDAIHTSAYGMGTSQRLANVDFFPNGPSTGVPGADNVVEATMRATRYFAESVRPGNERNFPSVAASSYQEYKQNKGYGKRGYMGIATDFDLQGDYILQVNSKSPFGRSTPAQKQTGYHQVHQPWRQSSSNQGSRRQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
31	Phosphorylation	GNRSGRRSNSLDNVE CCCCCCCCCCCCCCC	29.43	28490779
33	Phosphorylation	RSGRRSNSLDNVEQP CCCCCCCCCCCCCCC	38.04	28490779
67	Phosphorylation	LKKLQEMSLEEGATL HHHHHHCCHHHHHHH	31.70	22817900
82	Phosphorylation	LDKLYHLSQFNHVFK HHHHHHHHHCCCCCC	21.29	22817900
167	Phosphorylation	QRYNLQPYETTDYSN HHHCCCCCCCCCCCC	16.97	30478224
169	Phosphorylation	YNLQPYETTDYSNEE HCCCCCCCCCCCCHH	21.08	22817900
170	Phosphorylation	NLQPYETTDYSNEEQ CCCCCCCCCCCCHHH	22.47	22817900
172	Sulfation	QPYETTDYSNEEQSQ CCCCCCCCCCHHHHH	16.00	3139663
172	Phosphorylation	QPYETTDYSNEEQSQ CCCCCCCCCCHHHHH	16.00	22817900
172	Sulfation	QPYETTDYSNEEQSQ CCCCCCCCCCHHHHH	16.00	-
173	Phosphorylation	PYETTDYSNEEQSQR CCCCCCCCCHHHHHH	40.34	22817900
178	Phosphorylation	DYSNEEQSQRSSSEE CCCCHHHHHHCCHHH	30.73	22817900
181	Phosphorylation	NEEQSQRSSSEEQQT CHHHHHHCCHHHHHH	30.49	22817900
182	Phosphorylation	EEQSQRSSSEEQQTQ HHHHHHCCHHHHHHH	43.91	22817900
183	Phosphorylation	EQSQRSSSEEQQTQR HHHHHCCHHHHHHHH	46.53	22817900
357	Phosphorylation	ATRYFAESVRPGNER HHHHHHHHCCCCCCC	21.72	18327897
435	Phosphorylation	QPWRQSSSNQGSRRQ CCHHCCCCCCCCCCC	38.12	30478224

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of VIT2_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of VIT2_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of VIT2_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
VIT2_DROME	Yp2	physical	14605208
APLP_DROME	Rfabg	physical	22036573
PGK_DROME	Pgk	physical	22036573

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-31; SER-33; SER-82;THR-170; SER-173; SER-178; SER-181; SER-182 AND SER-183, AND MASSSPECTROMETRY.
PubMed: 18327897