PEP_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PEP_DROME
• UniProt AC: P41073
• Protein Name: Zinc finger protein on ecdysone puffs
• Gene Name: Pep
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 716
• Subcellular Localization: Nucleus . Chromosome . It is associated with the active ecdysone-regulated loci on polytene chromosomes, and on some heat shock-induced puffs. Its distribution pattern follows the changes of puffing patterns in the developmental program, or following
• Protein Description: May play a role in the process of early and late gene activation, or possibly in RNA processing, for a defined set of developmentally regulated loci..
• Protein Sequence: MVSVKVNGNPQNRLVNNAKVNGNMAFRGNQNRNRNFGGGNNNYGGPMGANRMGGMNMSPWESQNPGGGQFGNNMRQGGGQMNAQAINLANNLLNNLFRNQNPPSLLDLPRGGGGMGNRNQRGGPMVSRGGGAGNRLNNRRGQGGGFQNRGATGSGPKPPPKQGGGGIRKQNAFDRAKKLLAKNANQNKKKEPTPGEKKIESPTKESPYASVPNDMFYCHLCKKHMWDANSFENHIKGRTHLMMREGIEESYRLKANMIRQEAKIAEQLKSIEFDRLKRMGKSKQRQLDYCTMCDLNFHGHISTHRKSEGHLQLKKFLHPKCIECNKEFATRIDYDTHLLSAEHLKKAAENNTKVGERKRQTLPISTEEEETRDLRLPQKRKKKPVKKEGEAADGEAKKEGAGDGEGAEGDEAEGEEAKEGEEAADETKEGDELNESQEEEEVALPVDPEDCILDFNDGDEIPSEVDTRLPKYNWQRAVGPGLISKLECYECSVCSKFFDTEVTAEIHSRTATHHRNFLKFINEKSSDTKIAQKRAAAALEENERKKRKVEEAEAPAAEGAAEETTEGAEGELYDPSEATGDDEDVEMVDDNAEGEGEGEGDEEAEAEVEEDGAGQDNGEEEMEAQEEEGQEGEQEPEPEPAPVQTPAPAEPAPPAKTPAKTPTKAAAPAAVASPAAAATSADASPSPAKKATPARAAAGAKATPQRQRARGRYNRY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
104	Phosphorylation	FRNQNPPSLLDLPRG HHCCCCCCHHCCCCC	42.70	19429919
193	Phosphorylation	QNKKKEPTPGEKKIE CCCCCCCCCCCCCCC	45.04	19429919
201	Phosphorylation	PGEKKIESPTKESPY CCCCCCCCCCCCCCC	41.15	25749252
203	Phosphorylation	EKKIESPTKESPYAS CCCCCCCCCCCCCCC	57.64	23607784
206	Phosphorylation	IESPTKESPYASVPN CCCCCCCCCCCCCCC	25.43	23607784
208	Phosphorylation	SPTKESPYASVPNDM CCCCCCCCCCCCCCE	22.31	23607784
270	Phosphorylation	KIAEQLKSIEFDRLK HHHHHHHHHCHHHHH	35.62	25749252
307	Phosphorylation	HISTHRKSEGHLQLK CCCCCCCCCCCCCCH	49.09	19429919
427	Phosphorylation	GEEAADETKEGDELN HHHHHHHCCCCCCCC	34.64	29892262
436	Phosphorylation	EGDELNESQEEEEVA CCCCCCCCHHHHCCC	41.64	21082442
471	Acetylation	EVDTRLPKYNWQRAV CCCCCCCCCCHHHCC	56.67	21791702
657	Phosphorylation	EPAPPAKTPAKTPTK CCCCCCCCCCCCCCC	30.50	29892262
661	Phosphorylation	PAKTPAKTPTKAAAP CCCCCCCCCCCCCCC	37.99	19429919
663	Phosphorylation	KTPAKTPTKAAAPAA CCCCCCCCCCCCCHH	38.25	19429919
673	Phosphorylation	AAPAAVASPAAAATS CCCHHHCCHHHHHHC	14.42	21082442
679	Phosphorylation	ASPAAAATSADASPS CCHHHHHHCCCCCCC	21.52	19429919
680	Phosphorylation	SPAAAATSADASPSP CHHHHHHCCCCCCCH	21.30	19429919
684	Phosphorylation	AATSADASPSPAKKA HHHCCCCCCCHHHHC	26.85	21082442
686	Phosphorylation	TSADASPSPAKKATP HCCCCCCCHHHHCCH	34.69	21082442
692	Phosphorylation	PSPAKKATPARAAAG CCHHHHCCHHHHHHC	26.76	22817900
703	Phosphorylation	AAAGAKATPQRQRAR HHHCCCCCHHHHHHH	21.17	27626673

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PEP_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PEP_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PEP_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-201; THR-203; SER-206;SER-673; SER-684; SER-686 AND THR-692, AND MASS SPECTROMETRY.
PubMed: 18327897