| UniProt ID | VRET_DROME | |
|---|---|---|
| UniProt AC | Q9VCU7 | |
| Protein Name | Protein vreteno | |
| Gene Name | vret | |
| Organism | Drosophila melanogaster (Fruit fly). | |
| Sequence Length | 691 | |
| Subcellular Localization | Cytoplasm . Localizes to Yb bodies in follicle cells and to the meiotic nuage, also named P granule, in germline cells. | |
| Protein Description | Gonad-specific protein essential for germline development to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process in both germline and somatic gonadal tissues by mediating the repression of transposable elements during meiosis. Required for primary piRNA biogenesis in both germline and somatic gonadal tissues.. | |
| Protein Sequence | MESESSQDDWSAFDPMSREYYDQVGNRYTNESGQKLIMEAPLPPKDEKEQRATRQAKYPYLVVPKSSPYVTEKMLINFFGRALIKEMEFRRLSRVYFVYFENIASLETAQQRVQRYPNLIKCITGRPQKEREITSDPVTSTEPMPTPGPAISATERTPVNHNREVPISTGGQNHPEFFRPPLVTKDDYKRGSLLATNDPIQRYLNVKYEFALERHDIYKLKDETRIPQVVLHFRSGRTIPLSTVAVTEEDKTKSLLEDGVSKCVVCQNWTDTFCKLCKMPFCNASCFADVAEQHKQACGKGEILNLDEKVGRKYPKPGLPPSGSKVRITAFEQTNVVYVRSADIQIDIAYYTVLTEVMMLGKDASKLQSTPVCGQIVLYKFEGHMSRAMVLNVDNIKEIYVVFIDFGSVEVTQLERLYECSSYLAGLTCYPVAVKLRGVPRRFVGPNIREVMYELDQSLVFNIKYSSREYDTSKGMQVVVMTEIDINRSLNRLFKTILTPVEPSVSDLGYKEDCLPYIPLHCGKNINVVVMDNTFIQCGFIYCTSIDLAYEVTKMQRDIQEYGEKIAKCATYAPPINELCIAKYEGKWRRGLSVELVGDGYPSILFIDYGNIVPTHVTDIRPYPPQFIFPIMTTQLDLIGVPEKPTDEQIKWLDKNYPIGSVITCSEITFDEETNSYSTRIEKLQEFLSLD | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|
|---|---|---|---|---|---|---|
Oops, there are no PTM records of VRET_DROME !! | ||||||
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of VRET_DROME !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of VRET_DROME !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of VRET_DROME !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| DYL2_DROME | Cdlc2 | physical | 14605208 | |
| BX42_DROME | Bx42 | physical | 14605208 | |
| TBB1_DROME | betaTub56D | physical | 14605208 | |
| AGO3_DROME | AGO3 | physical | 21831924 | |
| PIWI_DROME | piwi | physical | 21831924 | |
| PIWI_DROME | piwi | physical | 21863019 | |
| AUB_DROME | aub | physical | 21831924 | |
| ARMI_DROME | armi | physical | 21831924 | |
| ARMI_DROME | armi | physical | 21863019 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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