BX42_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: BX42_DROME
• UniProt AC: P39736
• Protein Name: Puff-specific protein Bx42
• Gene Name: Bx42
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 547
• Subcellular Localization: Nucleus.
• Protein Description: May play a role in chromatin structure and function..
• Protein Sequence: MSLSSLLPTPTNAIWDREDERRLVARGAPKIGALVSAKIAAPPYGQRKDWVPHTDADFGDGGAFPEIHVAQYPLGLGAPGNVGKKSDALAVRLDDKGKVKYDAIARQGHGKDKIVYSSISQLLPAEVLAEDADELQRPDEETVMETTEETRLALEKLTNQKITSALPVRHAQKAGPAQYIRYTPSQQGDTFNSGAKQRVIRMVEAQLDPMEPPKFRINKKIPRGPPSPPAPVLHSPSRKVTVKEQKEWKIPPCISNWKNAKGYTIPLDKRLAADGRGLQQVHINEKFAKMAEALYIADRKAREAVEARSQLEKKLAQKEKEKKEDMLRMMAQRAREERAGLRNPEAAEPSGSGATGSEVRERNDLRAERQRERQRDRNLQRAAPEKRSKLQKERERDISEQIALGLPAKSAGNGETLFDQRLFNTTKGMDSGYGDDEAYNVYDKPWRDSNTLGAHIYRPSKQADSDNYGGDLDAIVNTKRFVPDKQFSGASKEAAAGQRSGPVEFEKEEDPFGLDQFLNMAKKAPKRAEEKNNERSSHSDRKRSKRD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
227	Phosphorylation	KIPRGPPSPPAPVLH CCCCCCCCCCCCCCC	46.80	21082442
235	Phosphorylation	PPAPVLHSPSRKVTV CCCCCCCCCCCCEEH	22.02	21082442
237	Phosphorylation	APVLHSPSRKVTVKE CCCCCCCCCCEEHHH	47.99	19429919

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of BX42_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of BX42_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of BX42_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
U520_DROME	l(3)72Ab	physical	22036573
CUT_DROME	ct	physical	25242320

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-227 AND SER-235, ANDMASS SPECTROMETRY.
PubMed: 18327897