CUT_DROME - dbPTM
CUT_DROME - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CUT_DROME
UniProt AC P10180
Protein Name Homeobox protein cut
Gene Name ct
Organism Drosophila melanogaster (Fruit fly).
Sequence Length 2175
Subcellular Localization Nucleus .
Protein Description Regulator of cell fate decisions in multiple lineages. Specifically, functions as a determination factor that specifies sensory organ identity in precursor cells. Probably also involved in cell type specification of Malpighian tubules. In absence of cut gene external sensory organs are transformed into chordotonal organs..
Protein Sequence MQPTLPQAAGTADMDLTAVQSINDWFFKKEQIYLLAQFWQQRATLAEKEVNTLKEQLSTGNPDSNLNSENSDTAAAAATAAAVAAVVAGATATNDIEDEQQQQLQQTASGGILESDSDKLLNSSIVAAAITLQQQNGSNLLANTNTPSPSPPLLSAEQQQQLQSSLQQSGGVGGACLNPKLFFNHAQQMMMMEAAAAAAAAALQQQQQQQSPLHSPANEVAIPTEQPAATVATGAAAAAAAAATPIATGNVKSGSTTSNANHTNSNNSHQDEEELDDEEEDEEEDEDEDDEEENASMQSNADDMELDAQQETRTEPSATTQQQHQQQDTEDLEENKDAGEASLNVSNNHNTTDSNNSCSRKNNNGGNESEQHVASSAEDDDCANNNTNTSNNNNTSNTATSNTNNNNNNNSSSGNSEKRKKKNNNNNNGQPAVLLAAKDKEIKALLDELQRLRAQEQTHLVQIQRLEEHLEVKRQHIIRLEARLDKQQINEALAEATALSAAASTNNNNNSQSSDNNKKLNTAAERPMDASSNADLPESTKAPVPAEDDEEDEDQAMLVDSEEAEDKPEDSHHDDDEDEDEDREAVNATTTDSNELKIKKEQHSPLDLNVLSPNSAIAAAAAAAAAAACANDPNKFQALLIERTKALAAEALKNGASDALSEDAHHQQQQHHQQQHQHQQQHHQQQHLHQQHHHHLQQQPNSGSNSNPASNDHHHGHHLHGHGLLHPSSAHHLHHQTTESNSNSSTPTAAGNNNGSNNSSSNTNANSTAQLAASLASTLNGTKSLMQEDSNGLAAVAMAAHAQHAAALGPGFLPGLPAFQFAAAQVAAGGDGRGHYRFADSELQLPPGASMAGRLGESLIPKGDPMEAKLQEMLRYNMDKYANQALDTLHISRRVRELLSVHNIGQRLFAKYILGLSQGTVSELLSKPKPWDKLTEKGRDSYRKMHAWACDDNAVMLLKSLIPKKDSGLPQYAGRGAGGAGGDDSMSEDRIAHILSEASSLMKQSSVAQHREQERRSHGGEDSHSNEDSKSPPQSCTSPFFKVENQLKQHQHLNPEQAAAQQREREREQREREQQQRLRHDDQDKMARLYQELIARTPRETAFPSFLFSPSLFGGAAGMPGAASNAFPAMADENMRHVFEREIAKLQQHQQQQQAAQAQAQFPNFSSLMALQQQVLNGAQDLSLAAAAAKDIKLNGQRSSLEHSAGSSSCSKDGERDDAYPSSLHGRKSEGGGTPAPPAPPSGPGTGAGAPPTAAPPTGGASSNSAAPSPLSNSILPPALSSQGEEFAATASPLQRMASITNSLITQPPVTPHHSTPQRPTKAVLPPITQQQFDMFNNLNTEDIVRRVKEALSQYSISQRLFGESVLGLSQGSVSDLLARPKPWHMLTQKGREPFIRMKMFLEDENAVHKLVASQYKIAPEKLMRTGSYSGSPQMPQGLASKMQAASLPMQKMMSELKLQEPAQAQHLMQQMQAAAMSAAMQQQQVAQAQQQAQQAQQAQQHLQQQAQQHLQQQQHLAQQQHPHQQHHQAAAAAAALHHQSMLLTSPGLPPQHAISLPPSAGGAQPGGPGGNQGSSNPSNSEKKPMLMPVHGTNAMRSLHQHMSPTVYEMAALTQDLDTHDITTKIKEALLANNIGQKIFGEAVLGLSQGSVSELLSKPKPWHMLSIKGREPFIRMQLWLSDANNVERLQLLKNERREASKRRRSTGPNQQDNSSDTSSNDTNDFYTSSPGPGSVGSGVGGAPPSKKQRVLFSEEQKEALRLAFALDPYPNVGTIEFLANELGLATRTITNWFHNHRMRLKQQVPHGPAGQDNPIPSRESTSATPFDPVQFRILLQQRLLELHKERMGMSGAPIPYPPYFAAAAILGRSLAGIPGAAAAAGAAAAAAAVGASGGDELQALNQAFKEQMSGLDLSMPTLKRERSDDYQDDLELEGGGHNLSDNESLEGQEPEDKTTDYEKVLHKSALAAAAAYMSNAVRSSRRKPAAPQWVNPAGAVTNPSAVVAAVAAAAAAAADNERIINGVCVMQASEYGRDDTDSNKPTDGGNDSDHEHAQLEIDQRFMEPEVHIKQEEDDDEEQSGSVNLDNEDNATSEQKLKVINEEKLRMVRVRRLSSTGGGSSEEMPAPLAPPPPPPAASSSIVSGESTTSSSSSSNTSSSTPAVTTAAATAAAGWNY
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
985PhosphorylationGGAGGDDSMSEDRIA
CCCCCCCCCCHHHHH
29.0225749252
1200PhosphorylationKLNGQRSSLEHSAGS
CCCCCHHHCCCCCCC
39.7121082442
1422AcetylationQYKIAPEKLMRTGSY
HCCCCHHHHHCCCCC
46.6621791702
1426PhosphorylationAPEKLMRTGSYSGSP
CHHHHHCCCCCCCCC
19.2621082442
1428PhosphorylationEKLMRTGSYSGSPQM
HHHHCCCCCCCCCCC
18.6021082442
1940PhosphorylationEGGGHNLSDNESLEG
CCCCCCCCCCCCCCC
43.6422817900
1944PhosphorylationHNLSDNESLEGQEPE
CCCCCCCCCCCCCCC
37.6722817900
2048PhosphorylationPTDGGNDSDHEHAQL
CCCCCCCCCHHHHHH
44.8822817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CUT_DROME !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CUT_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CUT_DROME !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
RL38_DROMERpL38genetic
10353901
ZEST_DROMEzgenetic
8842142
FSH_DROMEfs(1)hgenetic
25184680
OTU_DROMEotugenetic
10471713
SAYP_DROMEe(y)3genetic
8842142
POK_DROMEaopgenetic
15956666
CAPU_DROMEcapugenetic
10471713
ELP4_DROMECG6907genetic
15956666
PROF_DROMEchicgenetic
15956666
IF4A_DROMEeIF-4agenetic
15956666
WNTG_DROMEwggenetic
15956666
THIO2_DROMETrx-2genetic
15956666
KAPC_DROMEPka-C1genetic
9342058
ABRU_DROMEabgenetic
15363392
ABRU_DROMEabgenetic
15363393
CCNE_DROMECycEgenetic
15956666
BRAT_DROMEbratgenetic
15956666
TOP2_DROMETop2genetic
21304601
TRA1_DROMENipped-Agenetic
10353901
SDF2A_DROMECG14757genetic
15956666
1433Z_DROME14-3-3zetagenetic
15956666
PSC_DROMEPscgenetic
15956666
PSC_DROMEPscgenetic
8842142
SUZ2_DROMESu(z)2genetic
8842142
MAM_DROMEmamgenetic
8913756
TOPRS_DROMEToporsgenetic
21900273
RAC1_DROMERac1genetic
18093520
GNAI_DROMEGalphaigenetic
15956666
SMSR1_DROMESMSrgenetic
15956666
HAIR_DROMEhgenetic
15956666
EZ_DROMEE(z)genetic
8842142
BRM_DROMEbrmgenetic
15956666
ELL_DROMESu(Tpl)genetic
12096188
AEF1_DROMEAef1genetic
15956666
SCM_DROMEScmgenetic
8842142
TRX_DROMEtrxgenetic
15956666
SUHW_DROMEsu(Hw)genetic
1334893
SUHW_DROMEsu(Hw)genetic
2558282
SUHW_DROMEsu(Hw)genetic
8375652
SUHW_DROMEsu(Hw)genetic
8842142
SUHW_DROMEsu(Hw)genetic
8913756
SUHW_DROMEsu(Hw)genetic
21304601
CP190_DROMECp190genetic
21194420
OSA_DROMEosagenetic
15956666
SQZ_DROMEsqzgenetic
15956666
FUSIL_DROMEfusgenetic
15956666
LOLA1_DROMElolagenetic
15956666
LOLA2_DROMElolagenetic
15956666
LOLA3_DROMElolagenetic
15956666
LOLA4_DROMElolagenetic
15956666
LOLA6_DROMElolagenetic
15956666
LOLA5_DROMElolagenetic
15956666
VATA2_DROMEVha68-2genetic
15956666
COLL_DROMEkngenetic
18093520
IF4E_DROMEeIF-4Egenetic
15956666
ENY2_DROMEe(y)2genetic
8842142
MMD4_DROMEmod(mdg4)genetic
2558282
MMD4_DROMEmod(mdg4)genetic
9130717
MMD4_DROMEmod(mdg4)genetic
9439572
MMD4_DROMEmod(mdg4)genetic
11973303
MMD4_DROMEmod(mdg4)genetic
16209949
MMD4_DROMEmod(mdg4)genetic
16628226
MMD4_DROMEmod(mdg4)genetic
18369369
NIPB_DROMENipped-Bgenetic
15060134
NIPB_DROMENipped-Bgenetic
17909832
NELFA_DROMENelf-Aphysical
25242320

Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CUT_DROME

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1940 AND SER-1944, ANDMASS SPECTROMETRY.

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