SUHW_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SUHW_DROME
• UniProt AC: P08970
• Protein Name: Protein suppressor of hairy wing
• Gene Name: su(Hw)
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 941
• Subcellular Localization: Nucleus. Chromosome. Colocalizes with other elements of the gypsy chromatin insulator complex at multiple sites on polytene chromosomes and at nuclear insulator bodies.
• Protein Description: Component of the gypsy chromatin insulator complex which is required for the function of the gypsy chromatin insulator and other endogenous chromatin insulators. Chromatin insulators are regulatory elements which establish independent domains of transcriptional activity within eukaryotic genomes. Insulators have two defining properties; they can block the communication between an enhancer and a promoter when placed between them and can also buffer transgenes from position effect variegation (PEV). Insulators are proposed to structure the chromatin fiber into independent domains of differing transcriptional potential by promoting the formation of distinct chromatin loops. This chromatin looping may involve the formation of insulator bodies, where homotypic interactions between individual subunits of the insulator complex could promote the clustering of widely spaced insulators at the nuclear periphery. Within the gypsy insulator complex, this protein binds specifically to a region of the gypsy element located 3' of the 5' long terminal repeat (LTR), and may also mediate interaction with other endogenous insulators at sites distinct from those recognized by Cp190..
• Protein Sequence: MSASKEGKEKKGKLLGVENISPPKDKRPATRMKLLNDVGAGEDSEASTTTTTSRTPSNKQEKRGSVAGSRIKILNEEILGTPKTEKRGATKSTAPAASTVKILNEKKTPSATVTAVETTKIKTSPSKRKKMEHYVLQAVKSENTKADTTVTVVTEEDDTIDFILADDEEVVPGRIENNNGQEIVVTEDDEDLGEDGDEDGEDSSGKGNSSQTKIKEIVEHVCGKCYKTFRRVQSLKKHLEFCRYDSGYHLRKADMLKNLEKIEKDAVVMEKKDICFCCSESYDTFHLGHINCPDCPKSFKTQTSYERHIFITHSEFSDFPCSICNANLRSEALLALHEEQHKSRGKPYACKICGKDFTRSYHLKRHQKYSSCSSNETDTMSCKVCDRVFYRLDNLRSHLKQHLGTQVVKKPEYMCHTCKNCFYSLSTLNIHIRTHTGEKPFDCDLCDKKFSALVALKKHRRYHTGEKPYSCTVCNQAFAVKEVLNRHMKRHTGERPHKCDECGKSFIQATQLRTHSKTHIRPFPCEQCDEKFKTEKQLERHVKTHSRTKRPVFSCAECKRNFRTPALLKEHMDEGKHSPKQQRSSMRSAVKIMERTDCAICDKNFDSSDTLRRHIRTVHECDPDDIFGVEPHPSKRAKKDIESEEVVPVALNTSAGSLISSQTDGNGVVVREFLVDEGDGAAQTITLENETYTILPLDGAIEGEQLTDEAGVKPEAKKEEAQVSPVVKKEQRKSLAASLAAAIADNLEESCSEDDFSGEILTEEDIKLKENVGKLIDMLVDPPILKKYGWPNAPEETVLCKVIENCGHDLTKGGENYAELDYGSRMREYCKLLFTVVIHNDSIKSLLNNFPIDDVIEYVLGDEDQDEGGLDKDNESHSGDEEAVSVTGETKTNEIREKPEKKEVSAKSEKKEIVGKAVDKDNSEEVVRENKKKPVGEQEKA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
21	Phosphorylation	LLGVENISPPKDKRP CCCCCCCCCCCCCCC	46.89	19429919
65	Phosphorylation	NKQEKRGSVAGSRIK CCCHHCCCCCHHHEE	16.90	21082442
81	Phosphorylation	LNEEILGTPKTEKRG CCHHHHCCCCCCCCC	20.40	25749252
101	Acetylation	APAASTVKILNEKKT CCCHHHHHHHCCCCC	41.38	21791702
186	Phosphorylation	NGQEIVVTEDDEDLG CCCEEEEECCCHHCC	23.85	22817900
464	Phosphorylation	KKHRRYHTGEKPYSC HHCCCCCCCCCCCCC	37.79	22817900
578	Phosphorylation	HMDEGKHSPKQQRSS HHHCCCCCHHHHHHH	36.96	22668510
591	Acetylation	SSMRSAVKIMERTDC HHHHHHHHHHHHCCE	35.73	21791702
724	Phosphorylation	KKEEAQVSPVVKKEQ HHHHHCCCCCCCHHH	10.41	19429919
876	Phosphorylation	GLDKDNESHSGDEEA CCCCCCCCCCCCCCC	29.25	19429919
878	Phosphorylation	DKDNESHSGDEEAVS CCCCCCCCCCCCCEE	58.16	19429919
885	Phosphorylation	SGDEEAVSVTGETKT CCCCCCEEECCCCCC	22.47	19429919
887	Phosphorylation	DEEAVSVTGETKTNE CCCCEEECCCCCCCH	23.07	19429919
890	Phosphorylation	AVSVTGETKTNEIRE CEEECCCCCCCHHHC	44.51	19429919
916	Acetylation	EKKEIVGKAVDKDNS HHHHHHCEEECCCCH	34.05	21791702

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SUHW_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SUHW_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SUHW_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MMD4_DROME	mod(mdg4)	physical	7664338
FSH_DROME	fs(1)h	physical	23945939
DHB4_DROME	Mfe2	physical	25242320
RL38_DROME	RpL38	physical	25242320
TOPRS_DROME	Topors	physical	16209949
MSH6_DROME	Msh6	physical	23917615
BRM_DROME	brm	physical	23917615
EMS_DROME	ems	physical	23917615
SUHW_DROME	su(Hw)	physical	23917615
CP190_DROME	Cp190	physical	23917615
CP190_DROME	Cp190	physical	15574329
CP190_DROME	Cp190	physical	27599504
OSA_DROME	osa	physical	23609538
NU301_DROME	E(bx)	physical	25242320
MMD4_DROME	mod(mdg4)	physical	11416154
MMD4_DROME	mod(mdg4)	physical	18369369
MMD4_DROME	mod(mdg4)	physical	23209434
MMD4_DROME	mod(mdg4)	physical	23861668
MMD4_DROME	mod(mdg4)	physical	11350941
MMD4_DROME	mod(mdg4)	physical	15574329
MMD4_DROME	mod(mdg4)	physical	27599504

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-186, AND MASSSPECTROMETRY.
PubMed: 18327897