FSH_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FSH_DROME
• UniProt AC: P13709
• Protein Name: Homeotic protein female sterile
• Gene Name: fs(1)h
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 2038
• Subcellular Localization: Membrane ; Multi-pass membrane protein .
• Protein Description: Required maternally for proper expression of other homeotic genes involved in pattern formation, such as Ubx..
• Protein Sequence: MSSSEPPPRYEPPVEPVNGIVQPPVIPPAERPGRNTNQLQYLIKTVMKVIWKHHFSWPFQQPVDAKKLNLPDYHKIIKQPMDMGTIKKRLENNYYWSAKETIQDFNTMFNNCYVYNKPGEDVVVMAQTLEKVFLQKIESMPKEELELEPVTAKGGKKKQRAPATPKSSSGGAGASTGSGTSSAAVTSGPGSGSTKVSVAASSAQQSGLQGATGAGGGSSSTPGTQPGSGAGGAIAARPVSAMGGTVSSTAGGAPSIPPISTMPPHTVPGSTNTTTTAMAGGVGGPGAAGANPNAAALMASLLNAGQTGAYPGAPGQTAVNSSSLLDGSTAAVAAAAAAAAAAAAAAGGAAGAAGGAGTIPAVAVNAANAVQAYVNAGVSVGVDAVIPPQQPAKIKKGVKRKADTTTPTANAFESPYTQMDSKSAKIATRRESNRQDLTFQGSGYNMSPLGVSGVPGLGGLVAGGVAGVAVAKNKEKLSDALKSCNEILKELFSKKHSGYAWPFYKPVDAEMLGLHDYHDIIKKPMDLGTVKRKMDNREYKSAPEFAADVRLIFTNCYKYNPPDHDVVAMGRKLQDVFEMRYANIPDEPVANAAHHHGHGHGHGHGHGHGHGHGHGHGHGHGYGGSSSLKHDASDSSSEDSSDTENESNSDEERSARLKMLESKLLGLQEEIRKLSEEASAKKKAKKKLKEKKKSIGGGSGSGSASHHCHATGGGANAGGAGGPGSGGHGSVSVPGGVGSLGPGGAGGANLNALLGGSLVGHGGAAVAGGVPNVGALHSQVHDVAMAFSQMAGGGAAAGAGFGAGVTAAGASSGGKAGTLAGALAAGAAAGAGGTTAGSGSSKGAKSKGGRGAKGSGAGGVGASNNAAAGNAAGGAAGAAAGAGSVGGVGGAGAAGGGNASKRAKGSSSAGAGGGVGGANASAGGAGARGSSKKKPSQVMNFDSEEEDTAKPMSYDEKRQLSLDINKLPGDKLGRVVHIIQNREPSLRDSNPDEIEIDFETLKPSTLRELESYVASCLRKKTHKKPSGKSKDEQMAEKKQELEKRLQDVTGQLGASKKTAKKDESASSKVEAVQPANPVSSSSSSSDSSSSSSSDSSSSDSSDSEAGDGDERPPRKKKSRDSNGSNVNNPSINVVMGGNLPSGALSPTTMLMGLDHVVNSNTPTSQMSNMLGNANPLTAAAMLNNNNKTSLPGSNFGGAPAPGNMMHAGAGVPVAGAAVSASTGQQHNKNGPNDLSKVQPGGPINAALPPHSFAGGTATVATSQSSGGIRIASNLHKPSGLGGGDLGEHHAALAAALTSGINSTGTAGGGINNNGGSNNNANPLGGSHGDAMVNASLASLASGLKQIPQFDDPVEQSLASLEFSAGSTGKSGLTDNFLMQQHLMQPAGPQQQQQQQQQQPFGHQQQQQQQQQQQQQQQQHMDYVTELLSKGAENVGGMNGNHLLNFNLDMAAAYQQKHPQQQQQQAHNNGFNVADFGMAGFDGLNMTAASFLDLEPSLQQQQMQQMQLQQQHHQQQQQQTHQQQQQHQQQHHQQQQQQQLTQQQLQQQQQQQQQQQHLQQQQHQQQHHQAANKLLIIPKPIESMMPSPPDKQQLQQHQKVLPPQQSPSDMKLHPNAAAAAAVASAQAKLVQTFKANEQNLKNASSWSSLASANSPQSHTSSSSSSSKAKPAMDSFQQFRNKAKERDRLKLLEAAEKEKKNQKEAAEKEQQRKHHKSSSSSLTSAAVAQAAAIAAATAAAAVTLGAAAAAALASSASNPSGGSSSGGAGSTSQQAITGDRDRDRDRERERERSGSGGGQSGNGNNSSNSANSNGPGSAGSGGSGGGGGSGPASAGGPNSGGGGTANSNSGGGGGGGGPALLNAGSNSNSGVGSGGAASSNSNSSVGGIVGSGGPGSNSQGSSGGGGGGPASGGGMGSGAIDYGQQVAVLTQVAANAQAQHVAAAVAAQAILAASPLGAMESGRKSVHDAQPQISRVEDIKASPGGQGQSSPAQQSPQDRAAAKRAEQRRAEQERRRREALAGQIDMNMQSDLMAAFEETL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
432	Phosphorylation	KIATRRESNRQDLTF CHHHHCHHHCCCEEE	35.19	23607784
438	Phosphorylation	ESNRQDLTFQGSGYN HHHCCCEEEECCCCC	23.38	23607784
442	Phosphorylation	QDLTFQGSGYNMSPL CCEEEECCCCCCCCC	27.59	23607784
444	Phosphorylation	LTFQGSGYNMSPLGV EEEECCCCCCCCCCC	14.91	23607784
447	Phosphorylation	QGSGYNMSPLGVSGV ECCCCCCCCCCCCCC	17.21	23607784
452	Phosphorylation	NMSPLGVSGVPGLGG CCCCCCCCCCCCCCH	32.07	23607784
943	Phosphorylation	SQVMNFDSEEEDTAK HHCCCCCCCCCCCCC	42.65	19429919
948	Phosphorylation	FDSEEEDTAKPMSYD CCCCCCCCCCCCCHH	39.60	19429919
1586	Phosphorylation	PIESMMPSPPDKQQL CHHHCCCCCCCHHHH	31.04	27794539
1605	Phosphorylation	KVLPPQQSPSDMKLH CCCCCCCCHHHCCCC	22.56	25749252
1653	Phosphorylation	SSLASANSPQSHTSS HHHHHCCCCCCCCCC	24.84	22817900
1963	Phosphorylation	AMESGRKSVHDAQPQ HHHHCCCCHHHCCCC	24.27	19429919
1980	Phosphorylation	RVEDIKASPGGQGQS CHHHCCCCCCCCCCC	21.05	19429919
1987	Phosphorylation	SPGGQGQSSPAQQSP CCCCCCCCCCCCCCH	45.15	25749252
1988	Phosphorylation	PGGQGQSSPAQQSPQ CCCCCCCCCCCCCHH	19.16	25749252

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FSH_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FSH_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FSH_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RAC1_DROME	Rac1	genetic	25184680
TRX_DROME	trx	genetic	2497049
ASH2_DROME	ash2	genetic	2497049
GAGA_DROME	Trl	physical	23945939
SUHW_DROME	su(Hw)	physical	23945939
CP190_DROME	Cp190	physical	23945939
MMD4_DROME	mod(mdg4)	physical	23945939

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-452; SER-943; SER-1653;SER-1980 AND SER-1988, AND MASS SPECTROMETRY.
PubMed: 18327897