MSH6_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MSH6_DROME
• UniProt AC: Q9VUM0
• Protein Name: Probable DNA mismatch repair protein Msh6
• Gene Name: Msh6
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 1190
• Protein Description: Involved in post-replicative DNA-mismatch repair..
• Protein Sequence: MSKKLNTSVGGTPTNTLLNYFSKSPAFDKKKLTPSVKTDPDASKSEKENLQNQQPKVKDGKKEASKPAAKRKLPISDDEPASGQRKRKRIVQPESDSEPEMEVTKSEDDFSDCASDYEPDENEASDDSVSSGAEEVSPSENDMSVDSPTPKKSRKKSKILNNNNNNEPSSKKVKLESTIQLAEGATFQEKLKNLQSNAKQDASYDDIVTNTSNLDEPVVWPHQKLEFLQPDKIKDKEGRRPDHPDYDKSTLHVPEKFLNGLSPGVRQWWVLKSDNYDCVLFFKVGKFYELYHMDADVGVNELGFTYMRGEFAHSGFPEISFDKMSTILVDRGFKVARVEQTETPDMMTERCKRIKATKFDKVVAREICQITNRGTQVFGSQCKIGPNHQPNYMLAIVEKDEGTCSRYGVCFIDTSIGDFHLGEFEDDKNCSRLLTLVSHHMPVLFLNEKSALSQRTQQIVRTVLGGILKEPVPGNGKHACSAEKTLKLLAERYYAGPGSDDNWPLVLRTMQSDMDHLGLTPNDNYKLALKALGQCIFFIHKCKLEPKVLPMARYQLYVPPDQLADAKPAVASTLRRSHMVLDATTLSNLRIIGEEHSLLSTLDHCCTKFGKRLLHHWLCAPSCDVSVIKERQDAIGELIRMPTELQEVRALLAPMPDFERNLAQIHLFGNKQIKQMDHPDSRAILFEEKLYNKQKLQGFMAVLKGFNDLTKLPTMFHQCKTTLLKRITQLPESGGSFPDLSKELQYFATAFDHDAAAKTGVIAPQAGMDAEYDAAMDSIGEVEKRLKTYLVEQERHFGCRITYFGSDKKRYQLDVPESHASKANKSYTLEGQTKGKKPSRRYTTAETRALLKDMQHAEDTRNMVLKDLARRLFEKFSNHYDQWKQCIDCVANLDVLGSLAEYAGQQMVICVPELVSDADQPFIQLEEGYHPCANASTYIPNGLELGTASEAPLSLLTGPNMGGKSTLMREVGLLVIMAQIGAHIPAASCRLSLVDRIFTRLGAQDDILAGHSTFLVELNETSLILKHATCHSLVLLDELGRGTATYDGTAIAASVVNFLANLKCRTLFSTHYHNLIDFFHNDKRITLGHMACMVENEDNADPTQETVTFLYKYTAGACPKSYGFNAAKLAGMPQGIIKRAYELSKKVEAIALQRKITAKIVAATAGNEDTKKEKINALKDLLKQLKMCQV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MSKKLNTSVGGTPT -CCCCCCCCCCCCCC	34.91	22817900
8	Phosphorylation	MSKKLNTSVGGTPTN CCCCCCCCCCCCCCH	20.07	22817900
12	Phosphorylation	LNTSVGGTPTNTLLN CCCCCCCCCCHHHHH	22.47	28490779
14	Phosphorylation	TSVGGTPTNTLLNYF CCCCCCCCHHHHHHH	40.45	19060867
16	Phosphorylation	VGGTPTNTLLNYFSK CCCCCCHHHHHHHHC	34.79	30478224
20	Phosphorylation	PTNTLLNYFSKSPAF CCHHHHHHHHCCCCC	14.81	21082442
22	Phosphorylation	NTLLNYFSKSPAFDK HHHHHHHHCCCCCCC	23.12	22817900
24	Phosphorylation	LLNYFSKSPAFDKKK HHHHHHCCCCCCCCC	21.91	22817900
33	Phosphorylation	AFDKKKLTPSVKTDP CCCCCCCCCCCCCCC	23.54	18327897
82	Phosphorylation	ISDDEPASGQRKRKR CCCCCCCCCCCCCCC	46.29	22817900
95	Phosphorylation	KRIVQPESDSEPEME CCCCCCCCCCCCCCE	53.79	19429919
97	Phosphorylation	IVQPESDSEPEMEVT CCCCCCCCCCCCEEC	65.41	19429919
577	Phosphorylation	VASTLRRSHMVLDAT HHHHHHHHCCEEECC	14.97	21082442

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MSH6_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MSH6_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MSH6_DROME !!

Protein-Protein Interaction

Oops, there are no PPI records of MSH6_DROME !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-7; SER-8; THR-12;THR-14; THR-16; SER-22; SER-24; THR-33; SER-95 AND SER-97, AND MASSSPECTROMETRY.
PubMed: 18327897