NELFA_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NELFA_DROME
• UniProt AC: Q86NP2
• Protein Name: Negative elongation factor A
• Gene Name: Nelf-A
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 1251
• Subcellular Localization: Nucleus . Chromosome . Associates with polytene chromosomes. Associates with the hsp70 promoter when it is inactive, but not when it is activated.
• Protein Description: Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. Has an essential role in postembryonic development..
• Protein Sequence: MANVRDSDTSLWLHNKLGTSNDSWINGSICSQLNKEVLRNIKECFPDLQTQVKLKLLLSFLHIPRRLVEEWKAELEEVIEVAGLDSELWVSMLAETMKTFPATSSLNTEISDYEDTRPIFIDMVNDLRKLVTKHSDLGMLPLECQYLNKNALISVVGQQPAPVKHFTLKRKPKSAQLRTELLHKSADAQSSLKKASAPTIPLRSRGMPRKMTDTTPLKGIPSRMPTTGFRSATVPGNAAQRPNLSRTPAGRKDGGIKLIEFTEQPLGYAAAKKRKREQQLEEQQKKQEQKQQQAAAAAAAAATAAASNAGDSSPTDAATASGGETPVTPTSANNSFEIKMEPQQLNQSAGSLEEPQDDEMSGKANMECDIETPEYATATLDFAQATSTSVADGQPGKPAVETKLKTPRTPKSAAKLNNNNNNNNNNSFNHTPKRIKQEIEIKSEEIIVPASIKLEKIETSPSTQRVSIQQQPPSLVQRTPHLLIRSSPQKRQNNGATTSAGTTTTTVGNTTIKMEKLDIKPMIRATGVSPSTSAGTTTTLLTPQQLRQAANPLANLPNNISVKITSAKAKAAAAAAATSSGSQTQSQQPQTLQVQQAPQQSHPPLLINSSTPVILASSPSAQRAKALALPSSSTSATTTTTIPSQAIKTMPLSQLKTATNSGPVIISQTIIQPAKRAQQQAGTSSAAAASQQQQQQQSQQQLLHQQIQQQTQQQAQLPQQPQQQQTQYILATPQQQPQQIQQQQQQQQPILPTLTSFSHSRPMPQTTTLYQATTPSGSGQTPTKILLKTSGSSSVVMTPLRQAQPQQATAVVSSNPPPLVATSAAVVSPGQTTLNIQNVQLPNRPVTIQPASQAAQQQHMQAQLQQQQPHPQHTIVANTTATQQPKLSQVLMQPTAAVGTSGVSALNVSPTSGKNKTIILTQKGVILRNIGGDMYQQIPISNVGNMQGLGGTTLMTTTAGPPSLVKTTPSSGVQLQQQQSGKQILPTLIPTSSLGGQHVIVQQQQPTNVIGNSQQQTIIRPVMTNVGGGLTTLPQGLTLIQRPGQQPQLVQVQAAPGSTQRTIITQSNTAAAASQQQPRQQQQQILVQHKPAPTLQQRLVTSTTSGGQGQQGNPNAGLPRTVQVQVQAQQQQQPQQQQATQQQSQQAPQRRGLSLSNEHVHKAHEMFRKANRVSRPDKALILGFMAGLRENPRPNNENVLVIKLGETEEKVQQDNGHTALCLVESHIRLDYNTGEWKTFQNYRLQDQSAAS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
406	Phosphorylation	AVETKLKTPRTPKSA CCCCCCCCCCCCCHH	28.56	22817900
409	Phosphorylation	TKLKTPRTPKSAAKL CCCCCCCCCCHHHHH	35.95	22817900
431	Phosphorylation	NNNSFNHTPKRIKQE CCCCCCCCHHHHHHH	31.45	21082442
453	Acetylation	IIVPASIKLEKIETS EEEECEEEEEEEECC	48.36	21791702
459	Phosphorylation	IKLEKIETSPSTQRV EEEEEEECCCCCCEE	49.78	29892262
467	Phosphorylation	SPSTQRVSIQQQPPS CCCCCEEEEECCCCC	19.50	21082442
542	Phosphorylation	GTTTTLLTPQQLRQA CCEEEECCHHHHHHH	23.36	21082442
774	Phosphorylation	TTLYQATTPSGSGQT EEEEEEECCCCCCCC	20.62	19429919
776	Phosphorylation	LYQATTPSGSGQTPT EEEEECCCCCCCCCC	43.42	19429919
778	Phosphorylation	QATTPSGSGQTPTKI EEECCCCCCCCCCEE	31.87	19429919
781	Phosphorylation	TPSGSGQTPTKILLK CCCCCCCCCCEEEEE	36.13	19429919
783	Phosphorylation	SGSGQTPTKILLKTS CCCCCCCCEEEEEEC	33.82	19429919
909	Phosphorylation	GVSALNVSPTSGKNK CCCEEEECCCCCCCC	22.76	19060867
1090	Acetylation	QQILVQHKPAPTLQQ HHHHHHCCCCCCHHH	26.28	21791702
1154	Phosphorylation	APQRRGLSLSNEHVH HHHHHCCCCCHHHHH	32.35	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NELFA_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NELFA_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NELFA_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.