IF4A_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IF4A_DROME
• UniProt AC: Q02748
• Protein Name: Eukaryotic initiation factor 4A
• Gene Name: eIF4A {ECO:0000303|PubMed:18590813, ECO:0000312|FlyBase:FBgn0001942}
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 403
• Subcellular Localization: Cytoplasm . Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis.
• Protein Description: ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon. Involved in germ cell formation..
• Protein Sequence: MDDRNEIPQDGPASMEPEGVIESTWHEVYDNFDDMNLREELLRGIYGYGFEKPSAIQQRAIIPCVRGRDVIAQAQSGTGKTATFSIAILQQIDTSIRECQALILAPTRELATQIQRVVMALGEYMKVHSHACIGGTNVREDARILESGCHVVVGTPGRVYDMINRKVLRTQYIKLFVLDEADEMLSRGFKDQIQDVFKMLPPDVQVILLSATMPPDVLEVSRCFMRDPVSILVKKEELTLEGIKQFYVNVKQENWKLGTLCDLYDTLSITQSVIFCNTRRKVDQLTQEMSIHNFTVSAMHGDMEQRDREVIMKQFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPSNRENYIHRIGRGGRFGRKGVAINFITDDDRRILKDIEQFYHTTIEEMPANIADLI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
14	Phosphorylation	IPQDGPASMEPEGVI CCCCCCCCCCCCCCE	27.15	19429919
23	Phosphorylation	EPEGVIESTWHEVYD CCCCCEEECHHHHHH	26.18	19429919
24	Phosphorylation	PEGVIESTWHEVYDN CCCCEEECHHHHHHC	20.32	19429919
52	Acetylation	IYGYGFEKPSAIQQR HHCCCCCCCCHHHHH	41.85	21791702
136	Phosphorylation	SHACIGGTNVREDAR CCCCCCCCCHHHHHH	25.90	21082442
190	Acetylation	EMLSRGFKDQIQDVF HHHHCCCHHHHHHHH	52.10	21791702
235	Acetylation	PVSILVKKEELTLEG CEEEEEECCEECHHH	49.28	21791702
313	Acetylation	RDREVIMKQFRSGSS HHHHHHHHHHHCCCC	34.85	21791702

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of IF4A_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IF4A_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IF4A_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RS27A_DROME	RpS27A	physical	24292889
TFDP_DROME	Dp	genetic	10225996
E2F1_DROME	E2f	genetic	10225996
BAM_DROME	bam	physical	19556547

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.