dbPTM

SUZ2_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SUZ2_DROME
UniProt AC	P25172
Protein Name	Protein suppressor 2 of zeste
Gene Name	Su(z)2
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	1368
Subcellular Localization	Nucleus .
Protein Description	Regulates expression of the homeotic selector genes by influencing higher-order chromatin structure through interaction with other proteins..
Protein Sequence	MHLQNTHNTMESNAAMDAASPASRDVRQFHDLITCRLCRGYMIDPTTVDYCYHTYCRSCILKHLLRAVYCPECKASGGKEINELNLKSDDTLRSLIYKLVPGLYQRECKELADFKEQHDLVDEQTTDEPEFFTTTELISLSLEYHPAMLHQCGPGEVPPTIYLQCAAGLPVELLKRFLCSKYNIETDNGLVEVEVTYKDEVLPTNFTLMDVAYCYNWSRESPMAFCYRILLYDNEQTKNDENNLSRINQDIEPEHSVRRSKSAKSVTFAEDLESEIDSGSPRSKVRCKTPPKVSPSSKNKRLTSSKREAEPESPVSNFKSLRSNDMRYSDYAVSKVKSEPEQEQFLLPREREQQPLEANTNIVVSIPPSQLRKSYVDAEDFELKTANRKGVGHLPKLKIELNSMKSKLSMPLSAGPRLEDTSCSLSCSAQQLDLETYAKNIGLKPIEQPLQQSASNPDSKYSPNASPMSSCSSSTNGSSSSLGTADASTSTSTSSSHRKRKKKHSKEPKDANGKRKKLHAEISSQTDGKMKVKITAKPNHKLDFKRSHSLASGELDLQKLKLDSTSTSEALNRTLGEEARSINSLVVGGAPTPPPTPTAEPEQQQQQQQQQQQPQQQQQQQQQQQQQQQFVVLPKIKDLTLPTSPPLPPSLFKAYTPSTTPTAPHTVAGGKPKQQQQQMPQQPQAVLQQSLAKTNPAKPPLSSNNNRKPNSGHFAVPQAPTHRNMYHMQRYQSTPSSIASAANKMPKRSMSLDESHPAKQARLSQAQAMASSYAAKLHMQTSNQAKSQAAAFLPNPQMRSYGLPDLGSKPTLPMLCPASSSSQVTITPRPRATPSIYSFSEPNIHVPALEIVRLPVNKQSAGGKGLTMPPLSPPATSSARLMGPPAALPKHAGHGHGAAKRSCQMPTMPMPLPLPLPMPMTTIPAIVKSPPLSVALSGQRNNKGNSSNSNAYRTSPPALINLRNTAAPQHSFPSKSSPKVEANSKKSPPAAGCQGKTNGTAALDKSKTSLREFRPAVQSAVTATATTSVTTAAGAGAGAGTGTGTALAKDADILDLSANPGRSNNDAKLAPNSPPAGNNNNNNNNNNNNNNNNNNNNNNSTSNSLEAALNKIKQNISANSNGGPSTTSGSNSNGTTNGDDLQNLHMLSESATAREKISIKAASSGNGSGSTSSSSAKPKNANALVRPQNASVRSIPNPSALAFRNQPAAASTAASISKPLTVRAEEKPKVSTSNPGSLSPTNTSSSSSSSSSGSSGCSAATSPRAMTKKPTTIDQVAANLNIRAEAKAAALAEEAPPVLSSNAAKSPELAKTTTAVALRPEPKETPITVSAASTLLTIPSAVSSVSAVPETMAKPPVQIANAPVASSA

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
280	Phosphorylation	ESEIDSGSPRSKVRC HHHHHCCCCCHHCCC	22.53	22668510
313	Phosphorylation	KREAEPESPVSNFKS CCCCCCCCCCCCHHH	41.12	19429919
413	Phosphorylation	SKLSMPLSAGPRLED CHHCCCCCCCCCCCC	25.88	21082442
549	Phosphorylation	LDFKRSHSLASGELD CCCCHHHCCCCCCCC	27.20	19429919
643	Phosphorylation	IKDLTLPTSPPLPPS CCCCCCCCCCCCCHH	57.91	21082442
644	Phosphorylation	KDLTLPTSPPLPPSL CCCCCCCCCCCCHHH	23.68	21082442
733	Phosphorylation	YHMQRYQSTPSSIAS CCHHHHCCCHHHHHH	33.09	22817900
872	Phosphorylation	GLTMPPLSPPATSSA CCCCCCCCCCCCCHH	34.31	21082442
929	Phosphorylation	TIPAIVKSPPLSVAL CCCHHHCCCCCEEEE	22.36	19429919
955	Phosphorylation	NSNAYRTSPPALINL CCCCCCCCCCEEEEC	21.64	29892262
1306	Phosphorylation	LSSNAAKSPELAKTT CCCCCCCCHHHHHCC	20.91	22668510

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SUZ2_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SUZ2_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SUZ2_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MYC_DROME	dm	genetic	17311883
PSC_DROME	Psc	genetic	27510973
DLL_DROME	Dll	genetic	1968409
RING1_DROME	Sce	genetic	8313990

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SUZ2_DROME

Related Literatures of Post-Translational Modification