ELL_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ELL_DROME
• UniProt AC: Q9VW51
• Protein Name: RNA polymerase II elongation factor Ell
• Gene Name: Ell
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 1059
• Subcellular Localization: Nucleus . Nucleus, nucleolus . Chromosome . Localizes with RNA polymerase II at many transcriptionally active sites along polytene euchromatic chromosome arms and at developmental puff sites. Upon heat shock, relocalizes together with RNA polymerase
• Protein Description: Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. [PubMed: 11689450 Elongation factor component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III]
• Protein Sequence: MTNSIASTKCLPNALSTGNYGMSQSHRYTDDSKEYIIVKLTDSAFRAIEEYQRDDNAKRLQPGQRAKIQFVGNTGVIQFPRPATDANGIPNANGNGSDATGAGGGGGRKFGFTINNMEGTLECVQQQQRSLGVLGAVTLRMRIHANEDVYDSTRTKMAIAEETEKSKCIREIKPNQSDIGRKVKKPPSAIQSSASTASAFSSNSSNSGLTTTAFHHHSNSNNSGNNNNRSSSSSNSFNSNNHSRKLGSSPFNGLGVGSSSSSSAFASRSPNPSTLGAIGTVNGSGVVGGRYGGGAASSLASTFANGISQGYHNLSGSSPRDSMTAGTSSATASSVISSRNKMPSGGLTSSNSNSSSSSRSANSKSSGGNKMSDVSRRNIRERLIHLLALKAFKKPELFARLKNEGIRDRERNQITNILMDISTMSHNTYNLRRQMWNDVDENWPFFSEQEVQQLKRRKPQNLTPPMSSDAGSSTSGQSPTSTHTGSPPPPSSNGGPGGVGSGAGGTSMKRTSLEYDETMFSTVQPKKQRISHYKKDTPPSGTSYSSAGVSMSLGSSGSSSRSRYTPPQRQPGPLDDHSTTDLSYNVLDNIVEFMSSTAAATQQSMEQQQHPRSNSSNNRRGSSSLAGTSNGGNNKDKRNSTGSNSSSSSGYETQQDRQRSTTPMSSNRSSASSSTTPPKLAASFVPAATSGSASGTSKQRMPPQQSDYNSYNSNNAQHVASNSKKRMGSVGPSGGSNGQRQRSASGSNSGYQQVPPPSSNSRSSIQQQNQHQKQQVQQKQAPSQQQQQQQQQYHQQAKHPSPSQQLAAAAHAYAHATADTDSSATPRYDFSQYVPIQTLEVRRRYKTEFESDYDEYRKLLTRVEDVRNRFQDLSERLESARRCDNGYGDYDHIKRQIVCEYERINNDRTIGEDKERFDYLHAKLAHIKQLVMDYDKTLMSATMAMAPTDVVAAQGPDPAVAKAAARLAEHHRRQHHAAETIKQQQQQKQTHQHHLQRHLQHHLQQQQNLLQQQQNLLQQQSVSNSDDSSDSSDSNDDDDDDDEDCDDSNSNTDDDEARY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
622	Phosphorylation	SSNNRRGSSSLAGTS CCCCCCCCCCCCCCC		21082442
801	Phosphorylation	HQQAKHPSPSQQLAA HHHHCCCCHHHHHHH		22668510
828	Phosphorylation	DSSATPRYDFSQYVP CCCCCCCCCHHHCCC		22817900
831	Phosphorylation	ATPRYDFSQYVPIQT CCCCCCHHHCCCEEE		22817900
833	Phosphorylation	PRYDFSQYVPIQTLE CCCCHHHCCCEEEHH		22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ELL_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ELL_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ELL_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
AFF4_DROME	lilli	physical	22195968
ICE1_DROME	Ice1	physical	22195968
CCNT_DROME	CycT	physical	22195968
ICE2_DROME	Ice2	physical	22195968

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.