dbPTM

ICE1_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ICE1_DROME
UniProt AC	Q9W1R4
Protein Name	Little elongation complex subunit 1
Gene Name	Ice1
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	1395
Subcellular Localization	Nucleus . Associates to transcriptionally active chromatin at snRNA genes.
Protein Description	Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III. [PubMed: 22195968]
Protein Sequence	MNLDEFSDFNIDQLLGPSAPLQDALVAPYKQVSLPRSNQDVYAKRSRLAERIAQNDELIRQVKQLQAQNKQLADLQRTAQEVTDLYQKEKQQRIELEKRTKQIGERCGQLEKELDVQVGNCENLQEQLQVRGLPVEAKDVLSILMQFSQRLGDDCGLLRRDQNIMKKLREHCKTIDVSVPTPKSPNSRSKRKAHQPGVNQSTQTDEEPADPKPALCSVAVQVEGLIETRNQATQHKNTTTTRGTTTASFIKHHDVGTCFPEPKPLPNIRQILDEMLSWRDDVVIEPMSPLSDLQQELQLEDVPTNASVATCTTLCDIHREIDFVTDLPTQIKVSASRPPSRTMLDSVKEEARSSRELAKELFNFLPQNQSCLTNLPPQAFEELWQVFGQMVLALLQRRSNPSMATPPSVSQADFTRWLYELYEGTENQTEQTSNGSTSKRDFATSTECMDTGTDPIIQSPNISHEGHVTPIRLPSKPKERKRKSKKRKAAATPKPIAKRKCLEMETNNELEVEREQTPETAIQFLSNLETFNMANCDNLEMELDEEELYLLQLTSNAKQNENKGNVRVQDPDDLKSPAQTSKFPKSENHLPAVLKETASSLKGYDEKQCPFPDKTEELMHKKTFEIQENIGSLTELPPNIDISAYPVSMAEVRIVSSNKPSEMEVNASEGTDSHLDKSVSNLDTGSMSLFGSDSDVESEYSIEQMAPELSDSDDTFDNSEEDCRSADEPSNSKKIRNSSLFGSESESDESEERALEADDLTEAEAKVEEKESEQKSSDVAPAASSGKLLVVEADLVTKTQPLFVEKLDLENTQHTSTCTNPKETDESEDEHGLVIDEQIFISQPEEPPLTVPIAAKRRRTQSELKTLSPPGEVRLTRQRAKQLLDEQKSGPEKGLSLVEQIRRQLKKAINKSEPFKKDSTHDSKKDSTHDLKPLEHEDELKAMQLGTNFEPIKLSCSISEESPASPPACEPMDELDPPPIEIPLEQAACTRKDDQHKSIVQHVLKMDTGLEKLVEANRKTLGKSQPQLCASIGKYLQENMQLESTCSDLAMDIYKVTKSEAVIVNAMITVICKIGLDDGPVERLLNALKYLNFSQRFLAELEERLFRNTKERPATELALNYVRLYLKATALQATMSAGYENPARLLLAKILYHFDQDMPPLVMEVLRQFPTALPHREQREYDNSDALITVIKHLLMNRQYDMQDPNGAERLLLSKLRFEYHFQPYEPSKQQVLENLVGKLKAGREEELGYAFALFCRRSPHLKVVESVVGEHLMPLATSYCDLAAQNELYDARLGLLLHCISLVLKPLPLDTDISAFVGFLKRLLVAVPRSGVQLAAVKASLRLQRFGFKYTLDALKDYRPNYELDPLTRAMIRCFAKRRRHFRHVAATGRRTEI

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
Oops, there are no PTM records of ICE1_DROME !!

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ICE1_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ICE1_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ICE1_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
EAF_DROME	Eaf	physical	22195968
ELL_DROME	Su(Tpl)	physical	22195968
ICE2_DROME	Ice2	physical	22195968

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ICE1_DROME

Related Literatures of Post-Translational Modification