EAF_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EAF_DROME
• UniProt AC: Q7JRJ1
• Protein Name: Ell-associated factor Eaf
• Gene Name: Eaf
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 504
• Subcellular Localization: Nucleus.
• Protein Description: Promotes transcriptional elongation by Su(Tpl)/ELL. Essential for development..
• Protein Sequence: MMMTKQKNSLAERLNIGEEVRELKLGATFNPKNTSTAFHTIKYDFKPASVDTSRMASVDVGSNNQVTVTVPNSESSGVPHTVYKGNQREYAKECLMIYDKETGAITIEKLNHNIQVKKTRNEVTNKSVQLPGQNMGQPHNQGANGAAPVAVPVPGQGSGTAPKMENSTMRISTKTKVSTGSRRNNIIDFKPRNSPMQQNSPSRPVPVHRSPQSAPAWDANNAQQTLPSIPLITDDDDFGLRAALHNSGHGNTSGTAAGQPDFGSTSSSTHIGKQRQAPPHGHGKRQQMHQRLSPPMAQQQQPSNYGRGYNGGHNHAQQQQHHQRNSPQQQRPSAYGHGNSMPIDVDSSREHELTSQSVAQAAAALEQQIGGALSASSSSSESDSSDSDSGSDSDDSTEDDRSTQGQQQDHQQQQQQQHQVYQNHKHTQQQVAQQHHNQLPNLGLGSISPAYGSSHQQQHQQQMLPHQQKQKQQSGIYASNGGFPNDFLQNDLQLSSNSSDDDDD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
127	Phosphorylation	RNEVTNKSVQLPGQN CCHHCCCCCCCCCCC	19.71	22668510
168	Phosphorylation	APKMENSTMRISTKT CCCCCCCEEEEECCE	23.27	22668510
190	Acetylation	RNNIIDFKPRNSPMQ CCCCCCCCCCCCCCC	39.04	-
190	Acetylation	RNNIIDFKPRNSPMQ CCCCCCCCCCCCCCC	39.04	21791702
194	Phosphorylation	IDFKPRNSPMQQNSP CCCCCCCCCCCCCCC	24.03	22817900
200	Phosphorylation	NSPMQQNSPSRPVPV CCCCCCCCCCCCCCC	21.66	21082442
293	Phosphorylation	QQMHQRLSPPMAQQQ HHHHHHCCCCHHHHC	29.19	22817900
326	Phosphorylation	QQHHQRNSPQQQRPS HHHHHHCCHHHHCCC	26.69	19429919
333	Phosphorylation	SPQQQRPSAYGHGNS CHHHHCCCCCCCCCC	35.99	19429919
335	Phosphorylation	QQQRPSAYGHGNSMP HHHCCCCCCCCCCCC	17.62	19429919

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of EAF_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EAF_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EAF_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FAXC_DROME	fax	physical	14605208
LOLA1_DROME	lola	physical	14605208
LOLA2_DROME	lola	physical	14605208
LOLA3_DROME	lola	physical	14605208
LOLA4_DROME	lola	physical	14605208
LOLA6_DROME	lola	physical	14605208
LOLA5_DROME	lola	physical	14605208
RL31_DROME	RpL31	physical	14605208
FSH_DROME	fs(1)h	physical	14605208
TAFAB_DROME	Taf10b	physical	14605208
TCTP_DROME	Tctp	physical	14605208
ALF_DROME	Ald	physical	14605208
DORS_DROME	dl	physical	14605208

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-194, AND MASSSPECTROMETRY.
PubMed: 18327897