| UniProt ID | ELP4_DROME | |
|---|---|---|
| UniProt AC | Q9VMQ7 | |
| Protein Name | Putative elongator complex protein 4 | |
| Gene Name | CG6907 | |
| Organism | Drosophila melanogaster (Fruit fly). | |
| Sequence Length | 437 | |
| Subcellular Localization | Nucleus. | |
| Protein Description | Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation.. | |
| Protein Sequence | MTSFRKRTVQKPIRGTRTSPHTAQVITSSGNPYLDVVIGGGLPMGSICLIEEDRFMTHAKVLAKYFLAEGVISKQEIFLGSLDDIPAEMLRRLPRPLTDQESMEQSEVQALGDAGAENGLRIAWRYNDLPLVNSEHATAKIGHHFNLMEQMDSMMLYNVKTTLWDDSPKHLDIVIDEEFSKSSSPTTPSLEQQPVEDAPPIPGTETAPQEKMPAQEEENSANNNNNNNNNSSSVTSSTKTGSQDSPLQVFHNPRYKGLLNDIQQLLRNESFVAGTKNNLCRVCLTSLGSPLWYDEHFGEDLIKFLTLLMASVRNCNSVCLITMPMHLIAKYDASLVPKIRQLVDYAIELESFAGSERETHPAFKEYSGLLHLHKMSAINTLAVHMPETPDLAFKLRRKKFIIEKFHLPPELQESSAKPDNCISGLLSNSNATASLDF | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 182 | Phosphorylation | IDEEFSKSSSPTTPS ECHHHHCCCCCCCCC | 34.55 | 19429919 | |
| 183 | Phosphorylation | DEEFSKSSSPTTPSL CHHHHCCCCCCCCCH | 44.04 | 19429919 | |
| 184 | Phosphorylation | EEFSKSSSPTTPSLE HHHHCCCCCCCCCHH | 33.10 | 19429919 | |
| 186 | Phosphorylation | FSKSSSPTTPSLEQQ HHCCCCCCCCCHHCC | 53.97 | 22668510 | |
| 187 | Phosphorylation | SKSSSPTTPSLEQQP HCCCCCCCCCHHCCC | 17.79 | 19429919 | |
| 189 | Phosphorylation | SSSPTTPSLEQQPVE CCCCCCCCHHCCCCC | 42.31 | 19429919 | |
| 232 | Phosphorylation | NNNNNNSSSVTSSTK CCCCCCCCCCCCCCC | 30.83 | 30478224 | |
| 240 | Phosphorylation | SVTSSTKTGSQDSPL CCCCCCCCCCCCCCE | 42.00 | 21082442 | |
| 242 | Phosphorylation | TSSTKTGSQDSPLQV CCCCCCCCCCCCEEE | 35.73 | 22817900 | |
| 245 | Phosphorylation | TKTGSQDSPLQVFHN CCCCCCCCCEEECCC | 21.63 | 22817900 | |
| 399 | Acetylation | AFKLRRKKFIIEKFH HHHHHHCCEEEECCC | 39.73 | 21791702 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ELP4_DROME !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ELP4_DROME !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ELP4_DROME !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of ELP4_DROME !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "Phosphoproteome analysis of Drosophila melanogaster embryos."; Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.; J. Proteome Res. 7:1675-1682(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-183 AND SER-242, ANDMASS SPECTROMETRY. | |
