ANKHM_DROME - dbPTM
ANKHM_DROME - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ANKHM_DROME
UniProt AC Q9VCA8
Protein Name Ankyrin repeat and KH domain-containing protein mask
Gene Name mask {ECO:0000312|EMBL:AAO41600.1, ECO:0000312|FlyBase:FBgn0043884}
Organism Drosophila melanogaster (Fruit fly).
Sequence Length 4001
Subcellular Localization Cytoplasm . Cytoplasm, myofibril, sarcomere, Z line . Cytoplasm, myofibril, sarcomere, M line . In indirect flight muscle, more strongly associated with Z lines where it colocalizes with sls isoform A (kettin).
Protein Description Mediator of receptor tyrosine kinase (RTK) signaling, and may act either downstream of MAPK or transduce signaling through a parallel branch of the RTK pathway. [PubMed: 11782402 Required for the development and organization of indirect flight muscle sarcomeres by regulating the formation of M line and H zone and the correct assembly of thick and thin filaments in the sarcomere]
Protein Sequence MNNDAKNHESDDLNVRSTAYFNQQTTTNQPKAPATSKNNTGSGSGSNNNNNNTNQNPNRQLNHNLPRIAAARQSIAAALLKNSGRKILTAKNEPLTTTESSGVLTNTPLPSNSRLKVNNNNNTNNTAKMSGTSSSQSSATPTPPTASSSTTTTTTTNISTGGGGSGSSGGGGGSTTVIANPASVTNTGAGSAAKFRAAVASAPSPALPATNAPANATAAAAIAAIATAPAPSSSSSSSSSSKKTRAAVAALKRQVALQQQQPVTGNAPNMTSKDSAHLKFATTTLLMGAAAAAADSNAGAALGGSGAGGSGSSSSVGAVGGARMALNPAVDMANAAVLLKQKLKDAAAAASASASNRSATSSMSSTASSLSSSAGIVNAISSALQNIITPDTDTDTEFYPQPVTTDLSESEEESVSEDDIPESDPDSCPHEGEVREDEDETEEESEDSDESEGEEEEEDEEEIDVLQDNDADDEEIDDEDEEEDAPEVSSFLLDANNKRSSNISALLEAAANEKAPVLRHATHAIDETKQALTKMRCASSPRDKNSGFSRSLVAACTDNDVNTVKRLLCKGNVNLNDAAASTDDGESLLSMACSAGYYELAQVLLAMSAAQVEDKGQKDSTPLMEAASAGHLDIVKLLLNHNADVNAHCATGNTPLMFACAGGQVDVVKVLLKHGANVEEQNENGHTPLMEAASAGHVEVAKVLLEHGAGINTHSNEFKESALTLACYKGHLDMVRFLLQAGADQEHKTDEMHTALMEASMDGHVEVARLLLDSGAQVNMPTDSFESPLTLAACGGHVELATLLIERGANIEEVNDEGYTPLMEAAREGHEEMVALLLSKGANINATTEETQETALTLACCGGFMEVAAFLIKEGANLELGASTPLMEASQEGHTDLVSFLLKKKANVHAETQTGDTALTHACENGHTDAAGVLLSYGAELEHESEGGRTPLMKACRAGHLCTVKFLIQKGANVNKQTTSNDHTALSLACAGGHQSVVELLLKNNADPFHKLKDNSTMLIEASKGGHTRVVELLFRYPNISPTENAASANVTQAAPTSNQPGPNQMRQKIMKQQLQHQLQQLNAPPGLHELSEAARASNQQHFHQQQFSSAGNGSSNIVAMGTGDFLDAGELQLTATAGMSAGAGTSTTGSETGMEEYGEVGGIDLTTLGAQQQEGLIAKSRLFHLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQPPAAGQHQLVPCKHFDLDMEHINSLQPPQKAPPAPPVLFHTVCQQPVMQQQQQQLQPGQLKLKAMLPNRNRALKTAEVVEFIDCPVDQQQPGEQVRTQPLGEDGKTPQFACAGEDPRLQRRRGFMPELKKGELPPESSSSDPNELALKGADNNQPVPTALDNSACAQIPARNSGGAITHSSEVLQSTAISDRPKVKATNKNNRKQAAAAAAAAAAAAAAAAAAAQHAQQVLPNPMVSIYNNLHLQHLQHPHLQFQQQLQLHHQRVAGLDNAAAAAAAAASSANMAYSISPASPLPSPTGSGNYVDQQLQQQSMDVALQRKTAMDDFRGMLETAVNGPRGRKDLALNTPQLNFFKDGWHMVGVHNFFGDQPKSPTETPPEMEETTMSSPTEADRLGSEPRAEMKNLATLCSAAAAAAAVAAVNKDQVEISSDLESECEDDAEGGAGADCEENTLPPEPIELAAALREDGIIVEEEEDDEEEDDDDEEQDTNSGEVDKLNYDDEDAEVDNDGEVDYIDEDEGGGEGEEEEDDADDDEFFLDEPDSDQGTGNNNNNSKSGASSLPLKQRKMATRLENLILNSQTVCDFPPELSNSELVHVLPQISNLKAAANSNAALNSVLQQQLAAASAAAAHAKASVVHQKQQHGEGDQQCEDDGSASASELYSGLEHFANDGEMEDIFQELASSLNYPELAEFSLNQMCKGRFAGNWAQSSGKWTGQEQLVGVVRSPGLINPGDVPQDAQRQANLVLLDYPMQQNIQLEQRLLDAEEMHLQQHQQTPLSLLPFTDEQQQQLHHQALSNASDFQQHQQLALENDPELKQQLQQNSNARIIKAVAAQHQQQPPTNFVYNVESGDKNAPPVQLLFQLPPHMAQHQAQQQQGVGEPLTEQQQQQLHAEQAHLFQHRTGGQRPPTQSELEQVAQELLLQRSGQVPAGAPVVGVQAIPLKQKHFNLHPPPCPPTCVQHQVATQTHPASVVVPQPAVGYTQFALQASQQQQMQQNELSIWPMATPTPAPSSGVSSTKSMPGGIAKKAIDKQSRKERRCVVRQTPAGIQENTKLHLQPQVATAQQQFLVQNQLAVATTVSLDKTIEIDSETESNHDTALTLACAGGHEELVELLINRGANIEHRDKKGFTPLILAATAGHDKVVDILLKHSAELEAQSERTKDTPLSLACSGGRYEVVELLLSVGANKEHRNVSDYTPLSLAASGGYVNIIKLLLSHGAEINSRTGSKLGISPLMLAAMNGHTPAVKLLLDQGSDINAQIETNRNTALTLACFQGRHEVVSLLLDRRANVEHRAKTGLTPLMEAASGGYIEVGRVLLDKGADVNAAPVPTSRDTALTIAADKGHQKFVELLLSRNASVEVKNKKGNSPLWLAAHGGHLSVVELLYDHNADIDSQDNRRVSCLMAAFRKGHTKIVKWMVQYVSQFPSDQEMIRFIGTISDKELIDKCFDCMKILRSAKEAQAVKANKNASILLEELDLERTREESRKAAAARRRERKKKKKMEKKEEKRRQQQGNGPGGDDMQGDDDDASDKDDDSDKDDEDEEAAPAAAREEGDSGIDQGSCSSGDTKGARFGGSQSAQAAEAAANSVSTNSQGKKNKKQAKNKVLISVEPTQPVITSNSVLKGVCAKKHPAVEVVKQPPATQQAAPLKRQLDVKKEEPALKKKEEKNSSSSSSSKREKENLAPKEVALPAKQQPSSSSKLQSSESASNINSSTATNTSSANTTRKEVAKPASQTASATTLNPAKRTEVDGWKEVVRKSSAQQTTAVGASGAPLPVTATSSATSVQHHPHHHLANSSSNSSSSLTTSTTTAASSVPEMTCKKVQVPVNAISRVIGRGGSNINAIRATTGAHIEVEKQGKNQSERCITIKGLTDATKQAHMLILALIKDPDVDILQMLPRINSSIKQASSGGASTPMSVGTWDNRTAAGVNAYTFSSAASTTSTSSSSSASSTTPAGASYSNAHKQHQQQPQSVKGPSGRSSTSVKSNGSSTKVSASSGSGSRSGRAGSSYLAQQQPGRSSGGGSSNGVIKSKSESSSKSLPAAQKSSTTLGKSSTVSPGAQNFAKAAAIGQSSPKKAEGGATSAVVTSAGGRSSGVVAPFGRGKPVAGQGGPAATAASNVAQLGSVSGNSNILAGPIGTFNVADVAAVNAAAAAGAAAATNSNVKPIAPIAPPSKRVGSPTQVQQQHQTQQQQQQQLPQPAPVPGPQPQQQPLQQQQQQQAPQQQPQQPNQQQQPQTSQQNLVINTNLLNDLMAASAANTTSDSFSAQLAAKLSSAYSLFSDYQQSQWGKLGDPGIGGGAGAVGDGLPQADASKAPGYNRNILSSPVGSSKASSNHSTSPPVGNVIQQQQQQQPQSSQQALNIITSGPGGPATAPARSPMVSANEGNPAVGQPSMNGTQGLGETAPAHSPGVIKPPTATVPIQRHVPMPISAPEAGAPPTFGAIGSNPASGNNSAAAQAAAAAAASAMIDRQQQNLQNLQTLQNLQRMVGASQQQQPQQQLNYPMDPTSSFIVDANNVLRLNPRVIFPQGNTKPPQPPPQGGTQSNVFGGNPGRQPPGTGARQPGGAAAQRWYGGTLEYPSYTGRDMLHLENGAGGMAGMGSPSAMSPNHDDIRKMPRPIGTERAASWKYNNFNVGGPSLNMEDALASVLPPWAHELKAQPPGLQQPPPPPQSQQQQQQPLNWLKQQPQQQQYRAYNNGPYPQQQQQHEPMNMPMDYHNMQAPPNMSQQQQQHVNLMPSYGYQHFVGAPGAVDISAHMPDKMEVWDHHDKHMPWTNYTTNWSN
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
74PhosphorylationRIAAARQSIAAALLK
HHHHHHHHHHHHHHH		14.5119429919
500PhosphorylationLDANNKRSSNISALL
HCCCCCCCCCHHHHH		29.3719429919
501PhosphorylationDANNKRSSNISALLE
CCCCCCCCCHHHHHH		42.0619429919
504PhosphorylationNKRSSNISALLEAAA
CCCCCCHHHHHHHHH		19.6719429919
1389PhosphorylationAQIPARNSGGAITHS
CCCCCCCCCCCCCCC		32.8119429919
1563PhosphorylationRKDLALNTPQLNFFK
CCCCCCCCCCCCCCC		17.1719429919
1588PhosphorylationFFGDQPKSPTETPPE
CCCCCCCCCCCCCCC		43.6819429919
1590PhosphorylationGDQPKSPTETPPEME
CCCCCCCCCCCCCHH		60.6319429919
1592PhosphorylationQPKSPTETPPEMEET
CCCCCCCCCCCHHHC		46.7719429919
1599PhosphorylationTPPEMEETTMSSPTE
CCCCHHHCCCCCCHH		17.9429892262
1826PhosphorylationNLKAAANSNAALNSV
CHHHHHCCHHHHHHH		24.1021082442
1942PhosphorylationQLVGVVRSPGLINPG
HEEEEECCCCCCCCC		16.2319429919
2128PhosphorylationGQRPPTQSELEQVAQ
CCCCCCHHHHHHHHH		46.7821082442
2687PhosphorylationVKANKNASILLEELD
HHCCCCHHHHHHHHC		24.1419429919
2698PhosphorylationEELDLERTREESRKA
HHHCHHHHHHHHHHH		32.8122817900
2747PhosphorylationQGDDDDASDKDDDSD
CCCCCCCCCCCCCCC		52.7919429919
2753PhosphorylationASDKDDDSDKDDEDE
CCCCCCCCCCCCCCH		54.2619429919
2773PhosphorylationAAREEGDSGIDQGSC
HHHHHCCCCCCCCCC		48.8022817900
2805PhosphorylationAAEAAANSVSTNSQG
HHHHHHHHCCCCCCC		16.8421082442
2838PhosphorylationQPVITSNSVLKGVCA
CCEECCCHHHHHHHC		28.7021082442
2924PhosphorylationSKLQSSESASNINSS
HHCCCCCCHHCCCCC		38.6621082442
3226PhosphorylationSRSGRAGSSYLAQQQ
CCCCCCCCHHHCCCC		18.1521082442
3237PhosphorylationAQQQPGRSSGGGSSN
CCCCCCCCCCCCCCC		38.9721082442
3271PhosphorylationSSTTLGKSSTVSPGA
CCCCCCCCCCCCCCH		29.4621082442
3275PhosphorylationLGKSSTVSPGAQNFA
CCCCCCCCCCHHHHH		20.0829892262
3290PhosphorylationKAAAIGQSSPKKAEG
HHHHHCCCCCCCCCC		43.3119429919
3291PhosphorylationAAAIGQSSPKKAEGG
HHHHCCCCCCCCCCC		32.6219429919
3542PhosphorylationGYNRNILSSPVGSSK
CCCCCCCCCCCCCCC		28.8819429919
3543PhosphorylationYNRNILSSPVGSSKA
CCCCCCCCCCCCCCC		21.8419429919
3547PhosphorylationILSSPVGSSKASSNH
CCCCCCCCCCCCCCC		28.9719429919
3548PhosphorylationLSSPVGSSKASSNHS
CCCCCCCCCCCCCCC		26.7219429919
3596PhosphorylationPATAPARSPMVSANE
CCCCCCCCCCCCCCC		21.3222817900
3616PhosphorylationGQPSMNGTQGLGETA
CCCCCCCCCCCCCCC		17.9221082442
3820PhosphorylationGGMAGMGSPSAMSPN
CCCCCCCCCCCCCCC		13.5422817900
3822PhosphorylationMAGMGSPSAMSPNHD
CCCCCCCCCCCCCHH		38.0022817900
3825PhosphorylationMGSPSAMSPNHDDIR
CCCCCCCCCCHHHHH		23.4422817900
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ANKHM_DROME !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ANKHM_DROME !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ANKHM_DROME !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
LMLN_DROMEInvadolysinphysical
14605208
FTZF1_DROMEftz-f1physical
14605208
YAP1_DROMEykiphysical
23333314
YAP1_DROMEykiphysical
23333315
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ANKHM_DROME

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-501; SER-1588; SER-2687;THR-2698; SER-2747; SER-2753; SER-3596; SER-3820; SER-3822 ANDSER-3825, AND MASS SPECTROMETRY.
"An integrated chemical, mass spectrometric and computational strategyfor (quantitative) phosphoproteomics: application to Drosophilamelanogaster Kc167 cells.";
Bodenmiller B., Mueller L.N., Pedrioli P.G.A., Pflieger D.,Juenger M.A., Eng J.K., Aebersold R., Tao W.A.;
Mol. Biosyst. 3:275-286(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-501 AND SER-1389, ANDMASS SPECTROMETRY.

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