dbPTM

FOSLD_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	FOSLD_DROME
UniProt AC	A8MPH9
Protein Name	Transcription factor kayak, isoforms D/sro {ECO:0000250\|UniProtKB:P21525, ECO:0000303\|PubMed:18571877, ECO:0000312\|EMBL:ABI74757.1}
Gene Name	kay {ECO:0000303\|PubMed:18571877}
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	722
Subcellular Localization	Nucleus .
Protein Description	Developmentally regulated transcription factor AP-1 binds and recognizes the enhancer DNA sequence: 5'-TGA[CG]TCA-3'. May play a role in the function or determination of a particular subset of cells in the developing embryo. It is able to carry out its function either independently of or in conjunction with Jra..
Protein Sequence	MIALKATEMQHNNNALQQQQQLQHQLLQQHQQQHQQQLQQQLNSPDNNYIWATTHNANISRNNAMLQLQQQQLRAPWITDCNKQHHINNNNSMNVNYNQQLTQQPQQQQQQTQYMQHNYNNYTQQQQQQHLVPATTSQSNSHFYQCNQQQQQQQFLAPTTTTAAVVVAAAHQQHQTQQQHQSQQQQQHQRQDYASLQMGRQLGNFETGQSVLTLTTPTLTPTTTRNIEDTLGHLLSDTQTDRVAGCAGFAVPKVLPNAIDVLGMGIPTGVSSLPLQQTFDLSLGQGSESEDSNASYNDTQMNEEQDTTDTSSAHTDSTSYQAGHIMAGSVNGGGVNNFSNVLAAVSSSRGSASVGSSNANTSNTPARRGGGRRPNRSTNMTPEEEQKRAVRRERNKQAAARCRKRRVDQTNELTEEVEQLEKRGESMRKEIEVLTNSKNQLEYLLATHRATCQKIRSDMLSVVTCNGLIAPAGLLSAGSSGSGASSHHNHNSNDSSNGTITGMDATLNSTGRSNSPLDLKPAANIDSLLMHIKDEPLDGAIDSGSSLDQDGPPPSKRITLPPMSTMPHVHLSTILTPTGASSGSLQTPITSTAPGGFGSAFPVTSNGSSINNINSIGNNMNSPTLNAHNKVPKERPNTLAFQRPLGQMHLTMANNKAGGPTQIQGVPIQTPSTGTFNFDSLMDGGTGLTPVSGPLVPNSSSTNKHPLELPTPTAEPSKLVSL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
515	Phosphorylation	NSTGRSNSPLDLKPA CCCCCCCCCCCCCCC	28.25	18327897
718	Acetylation	TPTAEPSKLVSL--- CCCCCHHHCCCC---	64.72	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of FOSLD_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of FOSLD_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of FOSLD_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
JRA_DROME	Jra	physical	14605208
JRA_DROME	Jra	physical	23661758
SGG_DROME	sgg	genetic	18832361
PIGE_DROME	pigeon	genetic	18832361
JING_DROME	jing	genetic	16648585
LBM_DROME	lbm	genetic	18832361
JRA_DROME	Jra	genetic	9381174
JRA_DROME	Jra	genetic	18832361
SEM2A_DROME	Sema-2a	genetic	18832361
SDC_DROME	Sdc	genetic	18832361
SPY_DROME	sty	genetic	18832361
BICRD_DROME	CG32137	genetic	16648585
CPD1_DROME	D1	genetic	16648585
7UP1_DROME	svp	genetic	12049770
7UP2_DROME	svp	genetic	12049770
ATX2_DROME	Atx2	genetic	16648585
ATRX_DROME	XNP	genetic	16648585
JNK_DROME	bsk	genetic	9381174
HDAC1_DROME	Rpd3	physical	16391236

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of FOSLD_DROME

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos."; Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.; J. Proteome Res. 7:1675-1682(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-515, AND MASSSPECTROMETRY.	18327897 [Abstract]