| UniProt ID | JNK_DROME | |
|---|---|---|
| UniProt AC | P92208 | |
| Protein Name | Stress-activated protein kinase JNK | |
| Gene Name | bsk {ECO:0000312|FlyBase:FBgn0000229} | |
| Organism | Drosophila melanogaster (Fruit fly). | |
| Sequence Length | 372 | |
| Subcellular Localization | Nucleus . Cytoplasm . | |
| Protein Description | Responds to activation by environmental stress by phosphorylating a number of transcription factors, primarily components of AP-1 such as Jra and also the transcriptional repressor aop, and thus regulates transcriptional activity. [PubMed: 9224720 Component of the immune response activated by bacterial infection, and is involved in wound healing and in dorsal closure, a morphogenetic movement during embryogenesis] | |
| Protein Sequence | MTTAQHQHYTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALKHEYINVWYDAEEVDAPAPEPYDHSVDEREHTVEQWKELIYEEVMDYEAHNTNNRTR | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 127 | Phosphorylation | DLDHDRMSYLLYQML CCCHHHHHHHHHHHH | 17.33 | 19429919 | |
| 128 | Phosphorylation | LDHDRMSYLLYQMLC CCHHHHHHHHHHHHH | 7.44 | 19429919 | |
| 131 | Phosphorylation | DRMSYLLYQMLCGIK HHHHHHHHHHHHCHH | 6.84 | 19429919 | |
| 181 | Phosphorylation | AGTTFMMTPYVVTRY CCCEEECCCCCEEEE | 10.32 | 19429919 | |
| 183 | Phosphorylation | TTFMMTPYVVTRYYR CEEECCCCCEEEEEC | 9.82 | 19429919 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of JNK_DROME !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of JNK_DROME !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of JNK_DROME !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| PYRD_DROME | Dhod | physical | 14605208 | |
| GLIS2_DROME | sug | physical | 15575970 | |
| PTPS_DROME | pr | physical | 22036573 | |
| FAS2_DROME | Fas2 | genetic | 26586184 | |
| DSH_DROME | dsh | genetic | 17032066 | |
| POK_DROME | aop | genetic | 9224720 | |
| JRA_DROME | Jra | genetic | 9224720 | |
| JRA_DROME | Jra | genetic | 20035736 | |
| JRA_DROME | Jra | genetic | 9224721 | |
| SAC1_DROME | Sac1 | genetic | 14588244 | |
| HSP26_DROME | Hsp26 | genetic | 23264732 | |
| INSL2_DROME | Ilp2 | genetic | 19627268 | |
| FOSLD_DROME | kay | genetic | 20035736 | |
| FOSLA_DROME | kay | genetic | 20035736 | |
| HEP_DROME | hep | physical | 11912189 | |
| JRA_DROME | Jra | physical | 11410534 | |
| JRA_DROME | Jra | physical | 9584193 | |
| FOSLD_DROME | kay | physical | 11410534 | |
| FOSLA_DROME | kay | physical | 11410534 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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