dbPTM

SAC1_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SAC1_DROME
UniProt AC	Q9W0I6
Protein Name	Phosphatidylinositide phosphatase SAC1
Gene Name	Sac1
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	592
Subcellular Localization	Endoplasmic reticulum membrane Multi-pass membrane protein.
Protein Description	Phosphoinositide phosphatase that hydrolyzes PtdIns(3)P and PtdIns(4)P. Has low activity towards PtdIns(3,5)P2 (By similarity)..
Protein Sequence	MDSREENAVYDDMNLYIAPQSFIIEPNGGDELLVIGRHDKVTRVQPASGGLVANLRPTRRICGVLGTIHLLSCDYLLVATHRLFVGVLNGAVVWRLAGYDIIPYIPNSFQRKENENYLRLLRQTLDTKFFYFSYRYDLTNSLQRQREVAQSRPEVSGLLQRAEQRFVWNGYVLRQFNCDKMEKFQLPLVLGFVSINQVQINGQTFFWSIITRRSVQRAGTRLFCRGSDEQGHVANFVETEQIVEFNGQLTGFVQTRGSMPFHWHQLPNLRYKPRPVLVPGKDHLAACGLHFKEQIRLYGNNVAVNLVDHKGAEGELEATYARLVREMGNPQVRYESFDFHSECRKMRWDRLNILIDRLAHEQDQFGVYHVFDDGKLVSTQTGVFRTNCIDCLDRTNVVQSMLARRSLTAVLQKLGVLHVGQKVEHASDIFESIFKGVWADNADLVSLQYSGTCALKTDFTRTGKRTKSGAMQDGKNSLMRYYLNNFADGQRQDSIDLFLGKYLVNDNEGGAVPSPLESKHGWRFFTFPSVLLVAVAMFMITMTYPAEFNTENLLFMLFWGAMIAVSATGILHYGVEFVQWPRLFPPISFRDP

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
108	Phosphorylation	IIPYIPNSFQRKENE EECCCCCHHHHHCCH	19.87	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SAC1_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SAC1_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SAC1_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
CRB_DROME	crb	genetic	14588244

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SAC1_DROME

Related Literatures of Post-Translational Modification