CREBB_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CREBB_DROME
• UniProt AC: Q9VWW0
• Protein Name: Cyclic AMP response element-binding protein B
• Gene Name: CrebB {ECO:0000312|FlyBase:FBgn0265784}
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 359
• Subcellular Localization: Nucleus .
• Protein Description: Isoform E is a PKA-dependent transcriptional activator. Isoform J is a direct antagonist of activation by isoform E in cell culture. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. [PubMed: 7651429]
• Protein Sequence: MDNSIVEENGNSSAASGSNDVVDVVAQQAAAAVGGGGGGGGGGGGGNPQQQQQNPQSTTAGGPTGATNNAQGGGVSSVLTTTANCNIQYPIQTLAQHGLQVSIWGPGAWCQLSSVRCYGSQPEVATKDVQSVIQANPSGVIQTAAGTQQQQQALAAATAMQKVVYVAKPPNSTVIHTTPGNAVQVRNKIPPTFPCKIKPEPNTQHPEDSDESLSDDDSQHHRSELTRRPSYNKIFTEISGPDMSGASLPMSDGVLNSQLAGTGAGGNAANSSLMQLDPTYYLSNRMSYNTNNSGIAEDQTRKREIRLQKNREAARECRRKKKEYIKCLENRVAVLENQNKALIEELKSLKELYCQTKND

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
203	Phosphorylation	KIKPEPNTQHPEDSD CCCCCCCCCCCCCCC	38.68	22668510
209	Phosphorylation	NTQHPEDSDESLSDD CCCCCCCCCCCCCCC	41.43	19429919
212	Phosphorylation	HPEDSDESLSDDDSQ CCCCCCCCCCCCCHH	37.86	19429919
214	Phosphorylation	EDSDESLSDDDSQHH CCCCCCCCCCCHHHH	48.55	19429919
218	Phosphorylation	ESLSDDDSQHHRSEL CCCCCCCHHHHHHHH	38.11	19429919
230	Phosphorylation	SELTRRPSYNKIFTE HHHHHCCCHHHCCEE	39.25	22668510
231	Phosphorylation	ELTRRPSYNKIFTEI HHHHCCCHHHCCEEC	24.13	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CREBB_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CREBB_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CREBB_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GIANT_DROME	gt	physical	23661758
CREBB_DROME	CrebB	physical	23661758
HSP7D_DROME	Hsc70-4	genetic	16009936

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-209; SER-212 ANDSER-214, AND MASS SPECTROMETRY.
PubMed: 18327897