PSN_DROME - dbPTM
PSN_DROME - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PSN_DROME
UniProt AC O02194
Protein Name Presenilin homolog
Gene Name Psn
Organism Drosophila melanogaster (Fruit fly).
Sequence Length 541
Subcellular Localization Endoplasmic reticulum membrane
Multi-pass membrane protein. Golgi apparatus membrane
Multi-pass membrane protein.
Protein Description Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptor. Required for S3 cleavage of Notch, which releases activated Notch protein from the cell membrane. Involved in the patterning of the optic lobes..
Protein Sequence MAAVNLQASCSSGLASEDDANVGSQIGAAERLERPPRRQQQRNNYGSSNQDQPDAAILAVPNVVMREPCGSRPSRLTGGGGGSGGPPTNEMEEEQGLKYGAQHVIKLFVPVSLCMLVVVATINSISFYNSTDVYLLYTPFHEQSPEPSVKFWSALANSLILMSVVVVMTFLLIVLYKKRCYRIIHGWLILSSFMLLFIFTYLYLEELLRAYNIPMDYPTALLIMWNFGVVGMMSIHWQGPLRLQQGYLIFVAALMALVFIKYLPEWTAWAVLAAISIWDLIAVLSPRGPLRILVETAQERNEQIFPALIYSSTVVYALVNTVTPQQSQATASSSPSSSNSTTTTRATQNSLASPEAAAASGQRTGNSHPRQNQRDDGSVLATEGMPLVTFKSNLRGNAEAAGFTQEWSANLSERVARRQIEVQSTQSGNAQRSNEYRTVTAPDQNHPDGQEERGIKLGLGDFIFYSVLVGKASSYGDWTTTIACFVAILIGLCLTLLLLAIWRKALPALPISITFGLIFCFATSAVVKPFMEDLSAKQVFI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
129N-linked_GlycosylationINSISFYNSTDVYLL
HHHHHCCCCCCEEEE		36.10-
285PhosphorylationWDLIAVLSPRGPLRI
HHHHHHHCCCCCCHH		13.1222668510
353PhosphorylationATQNSLASPEAAAAS
HCCCCCCCHHHHHHC		28.6830478224
360PhosphorylationSPEAAAASGQRTGNS
CHHHHHHCCCCCCCC		30.6322817900
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PSN_DROME !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PSN_DROME !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PSN_DROME !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
METL_DROMEmetlphysical
11738826
NOTCH_DROMENgenetic
10491396
NOTCH_DROMENgenetic
10903180
NOTCH_DROMENgenetic
11134525
NOTCH_DROMENgenetic
21822800
STAR_DROMESgenetic
16415372
TBG1_DROMEgammaTub23Cgenetic
16415372
EYA_DROMEeyagenetic
16415372
SUH_DROMESu(H)genetic
16307735
SO_DROMEsogenetic
16415372
VG_DROMEvggenetic
16415372
METL_DROMEmetlgenetic
11738826
RAS3_DROMERgenetic
16415372
DIAP1_DROMEthgenetic
10491396
OPA_DROMEopagenetic
16415372
ITPR_DROMEItp-r83Agenetic
20631179
RAS1_DROMERas85Dgenetic
16415372
FLNA_DROMEchergenetic
10984440
GLAS_DROMEglgenetic
16415372
DL_DROMEDlgenetic
16415372
HLES_DROMEHgenetic
10903180
HLES_DROMEHgenetic
16307735
HLES_DROMEHgenetic
16415372
HH_DROMEhhgenetic
16415372
NICA_DROMEnctgenetic
16415372
GRM_DROMEmGluRgenetic
20631179
SPT5H_DROMESpt5genetic
16415372
PEN2_DROMEpen-2physical
20421416
APH1_DROMEaph-1physical
20421416
NICA_DROMEnctphysical
20421416
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PSN_DROME

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Related Literatures of Post-Translational Modification

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